3 results match your criteria: "Shinshu University School of Internal Medicine[Affiliation]"

The optimal second-line chemotherapeutic regimen for thymic carcinoma remains uncertain and predictive factors for the response have not been identified. We encountered two cases of relapsed thymic carcinoma with recurrence 1.5 and 8 years after initial response to cisplatin/doxorubicin/vincristine/cyclophosphamide (ADOC) chemotherapy.

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It has been reported that cisplatin-based chemotherapy shows beneficial effects in certain patients with advanced thymic carcinoma. However, the usefulness of salvage therapy has not been reported. We focused on a new anthracycline agent, amrubicin, combined with platinum compounds as salvage chemotherapy in patients with thymic carcinoma.

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Article Synopsis
  • The best chemotherapy treatment for thymic carcinoma is still unclear, and there’s little information about salvage therapy for this cancer.
  • In three cases of unresectable, locally advanced thymic carcinoma that didn’t respond to cisplatin, patients were given salvage chemotherapy with carboplatin and paclitaxel.
  • Two of the patients had a partial response, while one had a minor response, indicating that thymic carcinoma may be sensitive to these drugs, especially in combination with platinum-based therapies.
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