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RIPK2 and lysosomal pathway: Unveiling a new mechanism for lung cancer metastasis.

Transl Oncol

January 2025

Department of Oncology, Graduate school, Hebei Medical University, 050011, Shijiazhuang, China; Department of Oncology, Shijiazhuang Pelple's Hospital, 050030, Shijiazhuang, China. Electronic address:

Background: This study aims to explore the role of RIPK2 in lung cancer metastasis and its potential mechanisms.

Methods: The expression levels of RIPK2 in lung cancer patients and cell lines were detected by immunohistochemistry, qRT-PCR, and Western blot. RIPK2 expression was knocked down using siRNA technology, and its effects on the proliferation, migration, and invasion capabilities of lung cancer cells were assessed through CCK-8, EdU, colony formation, and Transwell assays.

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