1,384 results match your criteria: "Sher-i-kashmir Institute of Medical Sciences[Affiliation]"
J Asthma
October 2024
Department of Pulmonary, Critical Care and Sleep Medicine, All India Institute of Medical Sciences (AIIMS), New Delhi, India.
Objective: In this document, 9 Indian experts have evaluated the factors specific to LMICs when it came to Severe Asthma (SA) diagnosis, evaluation, biologic selection, non-biologic treatment options, and follow-up.
Data Sources: A search was performed using 50 keywords, focusing on the Indian/LMICs perspective, in PubMed, Cochrane Library, and Google Scholar. The key areas of the search were focused on diagnosis, phenoendotyping, non-biological therapies, selecting a biologic, assessment of treatment response, and management of exacerbation.
Mol Nutr Food Res
June 2024
Department of Biostatistics, All India Institute of Medical Sciences, New Delhi, India.
Scope: Association between vitamin B12 deficiency (VB12D) and dietary patterns being well documented has bearing on obstetrics and neonatal outcomes. However, relationship between VB12D and serum inflammatory markers (IMs), particularly in vegetarian diet and Polycystic ovary syndrome (PCOS), remains elusive. This cross-sectional study assesses VB12D and IMs among reproductive age women consuming different diets.
View Article and Find Full Text PDFCurr Pharm Des
October 2024
Department of General Medicine, Sher-I-Kashmir Institute of Medical Sciences (SKIMS), Srinagar, Jammu and Kashmir 190001, India.
In recent years, the field of nanotechnology has brought about significant advancements that have transformed the landscape of disease diagnosis, prevention, and treatment, particularly in the realm of medical science. Among the various approaches to nanoparticle synthesis, the green synthesis method has garnered increasing attention. Silver nanoparticles (AgNPs) have emerged as particularly noteworthy nanomaterials within the spectrum of metallic nanoparticles employed for biomedical applications.
View Article and Find Full Text PDFSaudi J Kidney Dis Transpl
November 2023
Department of Gastroenterology, Government Medical College Srinagar, Jammu and Kashmir, India.
J Obstet Gynaecol India
April 2024
Sher-i-Kashmir Institute of Medical Sciences, Srinagar, 190011 India.
Introduction: Ureteric colic in pregnancy is one of the common non-obstetric reasons for emergency department visits. Ureteric calculi present a significant threat to maternal and fetal health and definitive management often becomes necessary. Our aim is to assess the safety and efficacy of ureteroscopic laser lithotripsy in the management of ureteric stones in pregnancy.
View Article and Find Full Text PDFHeliyon
May 2024
Preclinical Research Laboratory, Department of Clinical Veterinary Medicine, Ethics & Jurisprudence, Sher-e-Kashmir University of Agricultural Sciences and Technology (SKUAST-Kashmir), Srinagar, J&K, 190006, India.
Cytokine storm (CS) refers to the spontaneous dysregulated and hyper-activated inflammatory reaction occurring in various clinical conditions, ranging from microbial infection to end-stage organ failure. Recently the novel coronavirus involved in COVID-19 (Coronavirus disease-19) caused by SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) has been associated with the pathological phenomenon of CS in critically ill patients. Furthermore, critically ill patients suffering from CS are likely to have a grave prognosis and a higher case fatality rate.
View Article and Find Full Text PDFDiscov Oncol
April 2024
Department of Hematology, SKIMS, Srinagar, 190011, J&K, India.
Background: Fragile histidine triad (FHIT) has been documented to play a vital role in various cancers including acute lymphoblastic leukemia (ALL). Keeping in view the plausible role of FHIT gene, we aimed to examine DNA promoter hypermethylation and mRNA expression in ALL cases in Kashmir (North India).
Methods: A total of 66 cases of ALL were analyzed for FHIT mRNA expression and promoter methylation by qRT-PCR and Methylation Specific-PCR (MS-PCR) respectively.
Curr Pharm Biotechnol
March 2024
Department of Biochemistry & Biotechnology, Faculty of Science, Annamalai University, Annamalainagar, 608002, Tamil Nadu, India
Background: Deregulated DNA damage response (DDR) network is implicated in cancer progression and therapy resistance.
Objective: The present study was designed to investigate whether nimbolide, an anticancer neem limonoid, targets key components of the DDR signalling pathway in cellular and animal models of oral squamous cell carcinoma (OSCC).
Methods: OSCC cells (SCC-4 and SCC-9), 7,12-dimethylbenz[a]anthracene (DMBA)-induced hamster buccal pouch (HBP) carcinoma model, chemoresistant OSCC patient-derived xenograft (PDX) model established in athymic nude mice, and tissue sections from patients with oral premalignant/malignant disease were used for the study.
BMJ Case Rep
March 2024
General Medicine, Division of Rheumatology, Sher-i-Kashmir Institute of Medical Sciences, Srinagar, Jammu & Kashmir, India.
We report the case of a man in his late 30s who presented with a history of breathlessness and cough with haemoptysis. Complete blood counts revealed pancytopenia. High-resolution CT showed diffuse bilateral ground glass opacities.
View Article and Find Full Text PDFInt J Gynaecol Obstet
September 2024
Department of Obstetrics and Gynecology, SKIMS, Srinagar, Jammu and Kashmir, India.
Objectives: Studies have investigated miR-125a for its predictable role in recurrent pregnancy loss (RPL) cases to regulate many biological events required for the maintenance of pregnancy by regulating its confirmed target genes LIFR, ERBB2 and STAT3.
Methods: The present study included 40 cases of women with at least two RPLs in ≤20 weeks of gestation against 40 healthy multiparous women without a previous history of abortion. Expression analysis of ERBB2, LIFR, STAT3 and miR-125a was conducted by quantitative real-time PCR (qPCR).
Osteoporos Int
May 2024
Department of Endocrinology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, 160012, India.
Unlabelled: Sheehan's syndrome (SS) is a rare but well-characterized cause of hypopituitarism. Data on skeletal health is limited and on microarchitecture is lacking in SS patients.
Purpose: We aimed to explore skeletal health in SS with bone mineral density (BMD), turnover, and microarchitecture.
Kidney Int Rep
March 2024
Department of Endocrinology, Sher-i-Kashmir Institute of Medical Sciences, Soura, Srinagar, Jammu and Kashmir, India.
Arab J Urol
December 2023
Department of Urology, Sher-I-Kashmir Institute of Medical Sciences, Srinagar, India.
Purpose: The prevalence of urinary stone disease in ESRD is 3.2%, leading to renal damage due to obstructive uropathy, infection, and frequent surgical intervention. PCNL, the gold standard for complex renal stone disease, has evolved with smaller access sheaths (14-20 F), improved optics, and fluoroscopic equipments.
View Article and Find Full Text PDFJ Pediatr Endocrinol Metab
May 2024
Department of Endocrinology, 29078 Sher-i-Kashmir Institute of Medical Sciences, Srinagar, Kashmir, India.
Objectives: The genetic causes of pituitary stalk interruption syndrome (PSIS) remain elusive in 95 % of cases. The roundabout receptor-1 gene () plays critical roles in axonal guidance and cell migration. Recently, mutations in the gene have been reported patients with PSIS.
View Article and Find Full Text PDFJ Anesth Analg Crit Care
March 2024
Department of Anaesthesiology, Sher I Kashmir Institute of Medical Sciences (SKIMS), Srinagar, Jammu and Kashmir, 190011, India.
Background: The efficacy of the erector spinae plane (ESP) block in mitigating postoperative pain has been shown for a range of thoracic and abdominal procedures. However, there is a paucity of literature investigating its impact on postoperative analgesia as well as its influence on weaning and subsequent recovery in comparison to thoracic epidural analgesia (TEA) in median sternotomy-based approach for open-cardiac surgeries and hence the study.
Methods: Irrespective of gender or age, 74 adult patients scheduled to undergo open cardiac surgery were enrolled and randomly allocated into two groups: the Group TEA (thoracic epidural block) and the Group ESP (bilateral Erector Spinae Plane block).
Arch Endocrinol Metab
February 2024
Radio Diagnosis and Imaging, Sher-I-Kashmir Institute of Medical Sciences, Srinagar, Kashmir, India.
Objective: Enlargement of the adrenal glands and variable adrenocortical function have been reported in patients with pulmonary tuberculosis and, in a few studies, in patients with extrapulmonary tuberculosis (EPTB). However, none of the studies have evaluated the course of the adrenal morphology in these patients.
Subjects And Methods: Prospective study including 37 patients with EPTB and 37 healthy age- and sex-matched controls.
J Hepatol
July 2024
Department of Hematology, Sher-i-Kashmir Institute of Medical Sciences. Soura, Srinagar, Jammu, and Kashmir, 190011, India.
Indian J Med Microbiol
May 2024
Regional VRDL, Indian Council of Medical Research-Regional Medical Research Centre for NE region (ICMR-RMRC NE), Dibrugarh, 786010, Assam, India. Electronic address:
Purpose: An acute conjunctivitis outbreak was investigated at a residential school in Naharlagun, Arunachal Pradesh, Northeast India, in July 2023. We aimed to identify the etiological agent and assess any complications in follow-up cases.
Methods: We used a structured questionnaire to record clinical findings and followed up with cases one-month post-conjunctivitis.
Lung India
March 2024
Sher-i-Kashmir Institute of Medical Sciences, Srinagar, Kashmir, India. E-mail:
Cureus
January 2024
Internal Medicine/Pulmonary Medicine, Sher-i-Kashmir Institute of Medical Sciences, Srinagar, IND.
Subacute thyroiditis (SAT) is a self-limiting inflammatory condition of the thyroid gland with distinct symptoms and a predictable outcome. During the current COVID-19 pandemic, there have been multiple isolated reports of SAT either during the active viral illness or following recovery. Here, we report two such cases of COVID-19 infection presenting with SAT.
View Article and Find Full Text PDFIndian J Med Res
January 2024
Division of Epidemiology & Biostatistics, ICMR-National Institute of Epidemiology, Chennai, India.
Front Pharmacol
January 2024
Department of Biotechnology, University of Kashmir, Srinagar, India.
P66Shc and Rac1 proteins are responsible for tumor-associated inflammation, particularly in brain tumors characterized by elevated oxidative stress and increased reactive oxygen species (ROS) production. Quercetin, a natural polyphenolic flavonoid, is a well-known redox modulator with anticancer properties. It has the capacity to cross the blood-brain barrier and, thus, could be a possible drug against brain tumors.
View Article and Find Full Text PDFCancer Metastasis Rev
March 2024
Department of Human Genetics-Precision Medicine in Diabetes, Obesity and Cancer Program, Sidra Medicine, Doha, Qatar.
Cancer is a complex disease displaying a variety of cell states and phenotypes. This diversity, known as cancer cell plasticity, confers cancer cells the ability to change in response to their environment, leading to increased tumor diversity and drug resistance. This review explores the intricate landscape of cancer cell plasticity, offering a deep dive into the cellular, molecular, and genetic mechanisms that underlie this phenomenon.
View Article and Find Full Text PDFInflammopharmacology
April 2024
Pharmaceutical Chemistry Division, Department of Pharmaceutical Sciences, University of Kashmir, Srinagar-190006, Hazratbal, Kashmir, India.
Background: Inflammation is a key biological reaction that comprises a complex network of signals that both initiate and stop the inflammation process.
Purpose: This study targets to evaluate the anti-inflammatory potential of the leaves of the Plectranthus rugosus (P. rugosus) plant involving both in vitro and in vivo measures.
J Natl Med Assoc
April 2024
Department of Endocrinology, Diabetes & Metabolism, Christian Medical College, Vellore, India.