4 results match your criteria: "Shenzhen Second People's Hospital the First Affiliated Hospital of Shenzhen University Shenzhen China.[Affiliation]"
Ovarian cancer (OV) ranks among the deadliest gynecological cancer, known for its high risk of relapse and metastasis, and a general resistance to conventional platinum-based chemotherapy. Selenoprotein I (SELENOI) is a crucial mediator implicated in human hereditary spastic paraplegia. However, its role in human tumors remains poorly elucidated.
View Article and Find Full Text PDFAortic aneurysm (AA) is an aortic disease with a high mortality rate, and other than surgery no effective preventive or therapeutic treatment have been developed. The renin-angiotensin system (RAS) is an important endocrine system that regulates vascular health. The ACE2/Ang-(1-7)/MasR axis can antagonize the adverse effects of the activation of the ACE/Ang II/AT1R axis on vascular dysfunction, atherosclerosis, and the development of aneurysms, thus providing an important therapeutic target for the prevention and treatment of AA.
View Article and Find Full Text PDFJ Am Heart Assoc
August 2024
Department of Rehabilitation, Shenzhen Second People's Hospital the First Affiliated Hospital of Shenzhen University Shenzhen China.
Background: Neuroinflammatory responses are closely associated with poststroke prognosis severity. This study aimed to develop a predictive model, combining inflammation-derived markers and clinical indicators, for distinguishing functional outcomes in patients with subacute ischemic stroke.
Methods And Results: Based on activities of daily living assessments, ischemic stroke participants were categorized into groups with little effective (LE) recovery and obvious effective (OE) recovery.
Clin Transl Immunology
January 2021
Objectives: Recent advances in patient-derived cancer organoids have opened a new avenue for personalised medicine. We aimed to establish an technological platform to evaluate chimeric antigen receptor (CAR)-T cell-mediated cytotoxicity against bladder cancer.
Methods: Patient-derived bladder cancer organoids (BCOs) were derived using classic medium containing R-spondin 1 and noggin.