2 results match your criteria: "Shenzhen No. 6 People's Hospital[Affiliation]"
Botulinum toxin type A reduces hyperalgesia and TRPV1 expression in rats with neuropathic pain.
Pain Med
February 2013
Shenzhen No.6 People's Hospital, Pain Medicine Department, Shenzhen, Guangdong, China.
Objective: We aim to determine the effects of botulinum toxin type A (BTX-A) on the thresholds of pain and the expression of transient receptor potential vanilloid type 1 (TRPV1) in the dorsal root ganglion (DRG) in rats with neuropathic pain induced by selective ventral root transection (VRT).
Methods: Neuropathic pain was induced by transection of the lumbar 5 ventral root in male Sprague-Dawley rats. BTX-A or saline was administered to the plantar surface by subcutaneous injection.
Botulinum toxin decreases hyperalgesia and inhibits P2X3 receptor over-expression in sensory neurons induced by ventral root transection in rats.
Pain Med
September 2011
Pain Medicine Department, Shenzhen No. 6 People's Hospital, Shenzhen, China.
Objectives: We aim to determine the effects of Botulinum toxin type A (BTX-A) on neuropathic pain behavior and the expression of P2X(3) receptor in dorsal root ganglion (DRG) in rats with neuropathic pain induced by L5 ventral root transection (L5 VRT).
Methods: Neuropathic pain was induced by L5 VRT in male Sprague-Dawley rats. Either saline or BTX-A was administered to the plantar surface.