mRNA shows promise for immunotherapy, protein replacement, and genome editing due to its ability to bypass genomic integration and function in non-dividing cells.
Efficient and safe delivery of mRNA is a major challenge, and advances in nanobiotechnology are helping develop nanocarriers for better mRNA transport.
The review highlights emerging nanomaterials, especially exosomes, for mRNA delivery, discusses clinical applications, and addresses obstacles in using mRNA nanocarriers along with strategies for improvement.