Risk factors and molecular epidemiology of colonizing carbapenem-resistant Enterobacterales in pediatric inpatient in Shenzhen, China.

Objectives: The spread of CRE has been rapid on a global scale and represents a significant challenge in nosocomial infections worldwide. The aim is to evaluate the risk factors for CRE colonization and to describe the molecular and clinical characteristics of CRE colonization in pediatric inpatients in Shenzhen, China.

Methods: We collected stool specimens from 2474 randomly selected pediatric inpatient hospitalized in 2 pediatric hospitals in Shenzhen between January 2023 and December 2023 for subsequent microbiological analysis, including microbial culture, species identification, antimicrobial sensitivity testing, genetic characterization and multilocus sequence typing (MLST).

Constructing small for gestational age prediction models: A retrospective machine learning study.

Objective: To develop machine learning prediction models for small for gestational age with baseline characteristics and biochemical tests of various pregnancy stages individually and collectively and compare predictive performance.

Study Design: This retrospective study included singleton pregnancies with infants born between May 2018 and March 2023. Small for gestational age was defined as a birth weight below the 10th percentile according to the Intergrowth-21st fetal growth standards.

Autosomal recessive renal tubular dysgenesis: antenatal ultrasound scanning and molecular investigations.

Objective: This study aimed to elucidate the fetal ultrasound characteristics, pathology, and molecular genetic etiology of autosomal recessive tubular dysplasia.

Methods: This retrospective study examined four fetuses with autosomal recessive tubular dysplasia (ARRTD) from two pregnancies, utilizing ultrasound evaluations and fetal renal pathology. Whole-exome sequencing-copy number variation analysis was employed to identify gene mutations.

NCLN as a potential prognosis biomarker in endometrial cancer.

Endometrial cancer (ECs) stands as one of the three major malignancies impacting females globally, with its incidence steadily increasing. ECs can be categorized into two types based on their clinicopathological features. Type I ECs typically exhibit low stage, favorable histological types, and low histological grade, correlating with a more favorable prognosis.

Hand and Foot Massage on Pain Management After Cesarean Section: A Meta-Analysis.

Background: Pain following a cesarean section is a significantly stressful experience, impeding women's fast recovery. Interventions such as hand and foot massage have been employed for pain management after cesarean sections, but their effectiveness remains undetermined.

Objective: To comprehensively explore the effects of hand and foot massage on improving pain management after a cesarean section.

Optimization of initial dosage of quetiapine in schizophrenic patients: effects of fluvoxamine or duloxetine coadministration.

Objective: Although quetiapine has been approved for use in schizophrenic patients, its individualized dosage regimen remains unclear, especially with respect to drug-drug interactions (DDIs). Thus, we investigated the potential DDIs and optimal initial dosage of quetiapine in schizophrenic patients based on population pharmacokinetics (PPK).

Methods: Ninety-six schizophrenic patients treated with quetiapine were included to establish the PPK model, which also includes coadministration of multiple drugs.

LC-MS-based quantitation of proteomic changes induced by Norcantharidin in MTB-Treated macrophages.

Tuberculosis drug resistance contributes to the spread of tuberculosis. Immunotherapy is an effective strategy for treating tuberculosis, with the regulation of macrophage-mediated anti-tuberculosis immunity being crucial. Norcantharidin (NCTD), a drug used in tumor immunotherapy, has significant immunomodulatory effects.

Prediction of preterm birth using machine learning: a comprehensive analysis based on large-scale preschool children survey data in Shenzhen of China.

Background: Preterm birth (PTB) is a significant cause of neonatal mortality and long-term health issues. Accurate prediction and timely prevention of PTB are essential for reducing associated child mortality and morbidity. Traditional predictive methods face challenges due to heterogeneous risk factors and their interaction effects.

The impact of gut microbiota in full-term pregnant women on immune regulation during pregnancy: A prospective, exploratory study.

Aim: This study aims to investigate the correlation between gut microbiota and both placental local immune function and the maternal systemic immune system in pregnant women.

Methods: Twenty-six pregnant women were included in this study, utilizing high-throughput sequencing for gut microbiota analysis. Immune cells and cytokine levels were measured in placental tissue and peripheral venous blood.

Embryo Cryopreservation Strategy May Improve Live Birth for Women Underwent In Vitro Maturation After Early Oocyte Retrieval: A Retrospective Cohort Study.

There is limited clinical research investigating the optimal transplantation strategy in early oocyte retrieval cycles. We aimed to assess whether the maturation of oocytes from early oocyte retrieval influenced pregnancy outcomes, and to find the optimal embryo transfer strategy (fresh or frozen-thawed embryo transfers) for patients who had early oocyte retrieval and underwent in vitro maturation (IVM). A retrospective cohort study was conducted in a university-based reproductive medical center.

Machine-learning models to predict myopia in children and adolescents.

Objectives: To explore machine-learning applications in myopia prediction and analyze the influencing factors of myopia.

Methods: Stratified cluster random sampling was used to select elementary school students in Shenzhen, China for inclusion in this case-control study. Myopia screening, ocular biological parameter measurements, and questionnaires were conducted.

Maternal exposure to fine particulate matter before and during pregnancy, and the risk of birth defects: A population-based study.

Although epidemiological evidence has linked maternal exposure to air pollution with adverse birth outcomes, the association between exposure to fine particulate matter (PM) and the risk of total birth defects in highly polluted developing regions remains limited. The objective of this study was to assess the relationship between maternal exposure to PM before and during pregnancy and the occurrence of birth defects. This study included 16,080 births with birth defects and 567,483 controls born between 2014 and 2019 in 14 cities in Liaoning Province, China.

[Prospective multicenter cohort study on breast cancer screening using an automated breast ultrasound with remote reading].

To construct a remote screening network for breast cancer based on automated breast ultrasound (ABUS) and explore the value of ABUS with remote reading for breast cancer screening. We constructed a remote breast cancer screening network including one remote reading center and 48 image-acquisition centers. We recruited women to participate in breast cancer screening at one of these image-acquisition centers from January 2021 to January 2023.

Role of CD38 in mediating the effect of Bacillus on acute pancreatitis: a study of mediated Mendelian randomization.

Background: Some studies suggest a potential link between intestinal flora and acute pancreatitis (AP). However, the causal relationships between specific intestinal flora and AP, and the possible mediating role of immune cell traits, remain unclear.

Methods: A genome-wide association study (GWAS) involving 5,959 participants was conducted to identify genetic instrumental variables associated with 473 intestinal flora taxa.

Compassion fatigue and it influencing factors among pediatric nurses: a cross-sectional survey.

Objective: This cross-sectional survey, utilizing a convenience sampling method, was conducted to investigate compassion fatigue (CF) among pediatric nurses in Shenzhen, China. Early identification of factors influencing compassion fatigue is a critical issue that nursing managers must address urgently.

Methods: A convenience sampling technique was employed, and 539 pediatric nurses from tertiary grade A hospitals in Shenzhen were assessed using the Professional Quality of Life Scale.

Chemogenetic silencing of the subiculum blocks acute chronic temporal lobe epilepsy.

Temporal lobe epilepsy (TLE) is the most common form of medically-intractable epilepsy. Subicular hyperexcitability is frequently observed with TLE, presumably caused by impaired inhibition of local excitatory neurons. Here, we evaluated the effectiveness of silencing subicular pyramidal neurons to treat a rodent model of TLE.

Targeted isolation of lignans and triterpenoids from kadsura coccinea by molecular networking and anti-RA-FLS activity.

In this study, six compounds (four triterpenoids named heilaohutriterpenes A-D and two lignans name heilaohusuins F and G) together with 21 known compounds were isolated from roots of Kadsura coccinea (Lem.) A. C.

Risk and burden of low birthweight related to maternal PM exposure in Iran: A national causal inference study.

Background: Maternal ambient fine particulate matter (PM) has been linked with fetal low birthweight (LBW), while national causal evidence is limited, particularly in low- and middle-income countries.

Methods: We used nationwide registry-based birth records of 3839531 singleton livebirths, with maternal age (MA) between 15 and 49 years, across 31 provinces in Iran from 2013 through 2018. Monthly gridded concentrations of ambient PM during entire pregnancy were estimated through validated spatiotemporal models.

Correlations of strength, proprioception, and dynamic balance to the Cumberland Ankle Instability Tool Score among patients with chronic ankle instability: a cross-sectional study.

Background: The Cumberland Ankle Instability Tool (CAIT) is used to screen patients with chronic ankle instability (CAI) and to quantify the severity of ankle instability. Neuromuscular deficits are common in CAI, including proprioception, strength, and balance issues. The relationship between CAIT scores and neuromuscular factors is unclear.