286 results match your criteria: "Shenzhen Blood Center Institute of Transfusion Medicine;Shenzhen 518040[Affiliation]"
Blood Adv
June 2024
Department of Anesthesiology and Intensive Care Medicine, University Hospital, Tübingen, Germany.
Pulmonary defense mechanisms are critical for host integrity during pneumonia and sepsis. This defense is fundamentally dependent on the activation of neutrophils during the innate immune response. Recent work has shown that semaphorin 7A (Sema7A) holds significant impact on platelet function, yet its role on neutrophil function within the lung is not well understood.
View Article and Find Full Text PDFHLA
March 2024
Shenzhen Institute of Transfusion Medicine, Shenzhen Blood Center, Shenzhen, China.
HLA-B*58:01:40 differs from HLA-B*58:01:01 by a single nucleotide change in exon 3, 507 C- > T (codon 145.3 CGC- > CGT).
View Article and Find Full Text PDFZhongguo Shi Yan Xue Ye Xue Za Zhi
February 2024
Shenzhen Blood Center Institute of Transfusion Medicine;Shenzhen 518040, Guangdong Province, China.
Front Cell Infect Microbiol
February 2024
Department of Transfusion Medicine, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou, China.
Introduction: Human brucellosis, a infection caused most common zoonosis in the world, remains a serious public health burden in China. chronic infection always causes immunosuppressive status and results in severe organ or tissue damages. The aim of this work was to study the role of the myeloid-derived suppressor cells (MDSCs) in human chronic brucellosis.
View Article and Find Full Text PDFNat Biotechnol
October 2024
Center for Computational Biology, Beijing Institute of Basic Medical Sciences, Beijing, China.
Integrating single-cell datasets produced by multiple omics technologies is essential for defining cellular heterogeneity. Mosaic integration, in which different datasets share only some of the measured modalities, poses major challenges, particularly regarding modality alignment and batch effect removal. Here, we present a deep probabilistic framework for the mosaic integration and knowledge transfer (MIDAS) of single-cell multimodal data.
View Article and Find Full Text PDFBlood Adv
April 2024
Department of Internal Medicine, Ulm University Hospital, Ulm, Germany.
Guadecitabine is a novel hypomethylating agent (HMA) resistant to deamination by cytidine deaminase. Patients with relapsed/refractory acute myeloid leukemia (AML) were randomly assigned to guadecitabine or a preselected treatment choice (TC) of high-intensity chemotherapy, low-intensity treatment with HMAs or low-dose cytarabine, or best supportive care (BSC). The primary end point was overall survival (OS).
View Article and Find Full Text PDFZhonghua Yi Xue Yi Chuan Xue Za Zhi
January 2024
Shenzhen Institute of Transfusion Medicine, Shenzhen Blood Center, Shenzhen, Guangdong 518035, China.
Objective: To develop a genotyping method for the Junior blood type and report on a rare blood type with Jr(a-).
Methods: Healthy O-type RhD+ volunteer donors of the Shenzhen Blood Center from January to May 2021 (n = 1 568) and a pedigree with difficult cross-matching (n = 3) were selected as the study subjects. Serological methods were used for proband's blood type identification, unexpected antibody identification, and antibody titer determination.
Zhonghua Yi Xue Yi Chuan Xue Za Zhi
January 2024
Institute of Transfusion Medicine, Shenzhen Blood Center, Shenzhen, Guangdong 518020, China.
J Cancer Res Ther
December 2023
Department of Hematology, Huazhong University of Science and Technology Union Shenzhen Hospital, Shenzhen, China.
In December 2022, the Omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) became dominant in China due to its high infectivity and lower mortality rate. The risk of critical illness and mortality among patients with hematologic malignancies who contracted SARS-CoV-2 was particularly high. The aim of this study was to draft a consensus to facilitate effective treatments for these patients based on the type and severity of the disease.
View Article and Find Full Text PDFJ Clin Virol
February 2024
School of Public Health, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China; Centre for Immunology and Infection(C2i), Hong Kong Science Park, Hong Kong SAR, China. Electronic address:
Background: Natural SARS-CoV-2 infection may elicit antibodies to a range of viral proteins including non-structural protein ORF8. RNA, adenovirus vectored and sub-unit vaccines expressing SARS-CoV-2 spike would be only expected to elicit S-antibodies and antibodies to distinct domains of nucleocapsid (N) protein may reliably differentiate infection from vaccine-elicited antibody. However, inactivated whole virus vaccines may potentially elicit antibody to wider range of viral proteins, including N protein.
View Article and Find Full Text PDFInt J Gen Med
November 2023
Business Management Department, Shenzhen Blood Center, Shenzhen, People's Republic of China.
Background: The adverse donor reaction (ADR) means the uncomfortable feeling felt by blood donors during the whole process of blood donation, which can affect the blood donation behavior of blood donors. So, it is very necessary for blood centers to monitor and prevent it.
Methods: Data about ADRs in Shenzhen Blood Center from January 2018 to December 2022 were collected, and correlation analysis was conducted using SPSS 24.
HLA
January 2024
Shenzhen Blood Center, Shenzhen Institute of Transfusion Medicine, Shenzhen, China.
HLA
January 2024
Shenzhen Blood Center, Shenzhen Institute of Transfusion Medicine, Shenzhen, China.
HLA-A*02:1103 differs from HLA-A*02:01:01:01 by one nucleotide change at nucleotide 811 in exon 4 from G to A.
View Article and Find Full Text PDFHLA
January 2024
Department of Clinical Laboratory, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen, Guangdong, China.
The novel HLA-A*33:244 allele contains a c.553G>A substitution in exon 3 compared with A*33:03:01:01.
View Article and Find Full Text PDFNat Med
January 2024
WHO Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.
Zhongguo Shi Yan Xue Ye Xue Za Zhi
October 2023
Institute of Blood Transfusion Medicine, Shenzhen Blood Center, Shenzhen 518000, Guangdong Province, China. E-mail:
Objective: The characteristics of the full-length mRNA sequences of MNS blood group-related genes , and were analyzed to understand the polymorphism of MNS blood group genes.
Methods: Anticoagulated blood within 24 h from 500 unpaid blood donors (8 ml each) were randomly selected, and MN, Ss and Mia blood types were identified by serological methods. 5 samples with different combinations of MNS and Mia blood types were randomly selected from 500 samples, and peripheral blood mononuclear cells (PBMC) were isolated by density gradient centrifugation, then total mRNA was extracted.
HLA
January 2024
Shenzhen Blood Center, Institute of Transfusion Medicine, Shenzhen, China.
HLA-A*11:452N differs from A*11:01:01:01 by a single nucleotide exchange in exon 1.
View Article and Find Full Text PDFHLA
December 2023
Shenzhen Blood Center, Institute of Transfusion Medicine, Shenzhen, Guangdong, China.
HLA-A*26:206:02N differs from A*26:01:01:01 by a single nucleotide exchange in exon 3.
View Article and Find Full Text PDFJ Neuroinflammation
September 2023
Department of Neurology, University Hospital Essen, University of Duisburg-Essen, Hufelandstr. 55, 45147, Essen, Germany.
Clin Kidney J
September 2023
Department of Nephrology, Shandong Provincial Hospital affiliated to Shandong First Medical University, Jinan, Shandong, China.
Background: Reduced survival of red blood cells (RBCs) in patients with chronic kidney disease (CKD) is thought to contribute to renal anaemia. Although renal anaemia improved greatly because of the wide use of erythropoiesis-stimulating agents (ESAs) and the advancement of dialysis techniques, RBC longevity seems not to be obviously ameliorated.
Methods: In this single-centre, single-arm trial, patients who had been undergoing haemodialysis and ESA therapy with epoetin alfa for at least 12 weeks changed their anti-anaemia drugs from epoetin alfa to oral roxadustat three times per week for 24 weeks.
Zhonghua Wai Ke Za Zhi
October 2023
First Department of Hepatobiliary Surgery,Zhujiang Hospital, Southern Medical University;Guangdong Provincial Clinical and Engineering Center of Digital Medicine,Guangzhou 510282,China.
To investigate the application value of augmented reality navigation combined with indocyanine green(ICG) fluorescence imaging technology in laparoscopic anatomical segment 8 liver resection. Clinical and pathological data from 8 patients with hepatocellular carcinoma located in segment 8 of the liver admitted to the First Department of Hepatobiliary Surgery,Zhujiang Hospital,Southern Medical University from October 2021 to October 2022 were collected restrospectively. Among them,there were 5 males and 3 females,aged between 40 and 72 years.
View Article and Find Full Text PDFJ Med Virol
August 2023
Provincial Key Laboratory for Transfusion-transmitted Infectious Diseases, Institute of Blood Transfusion (IBT), Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Chengdu, Sichuan, China.
A small percentage of couples who regularly donated blood in China tested positive for HBsAg. Although it is well known that blood donors can acquire hepatitis B virus (HBV) infection from a chronically infected sexual partner, the prevalence of occult hepatitis B infections (OBIs) among blood donations from partners of HBV-infected chronically infected spouses and the risk to blood safety remain poorly understood. Among 212 763 blood donors, 54 pairs of couples (108 donations) were enrolled because one partner tested positive for HBsAg.
View Article and Find Full Text PDFLancet Reg Health West Pac
July 2023
State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Background: Stroke ranks second worldwide and first in China as a leading cause of death and disability. It has a polygenic architecture and is influenced by environmental and lifestyle factors. However, it remains unknown as to whether and how much the genetic predisposition of stroke is associated with disease burden.
View Article and Find Full Text PDFAnn Surg Oncol
October 2023
Department of Hepatopancreatobiliary and Transplant Surgery, Singapore General Hospital and National Cancer Centre Singapore, Singapore, Singapore.
HLA
October 2023
Shenzhen Institute of Transfusion Medicine, Shenzhen Blood Center, Shenzhen, Guangdong, China.
HLA-B*13:179 differs from HLA-B*13:99 by one nucleotide substitution at position 829(A>G) in exon 4.
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