286 results match your criteria: "Shenzhen Blood Center Institute of Transfusion Medicine;Shenzhen 518040[Affiliation]"

Pulmonary defense mechanisms are critical for host integrity during pneumonia and sepsis. This defense is fundamentally dependent on the activation of neutrophils during the innate immune response. Recent work has shown that semaphorin 7A (Sema7A) holds significant impact on platelet function, yet its role on neutrophil function within the lung is not well understood.

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HLA-B*58:01:40 differs from HLA-B*58:01:01 by a single nucleotide change in exon 3, 507 C- > T (codon 145.3 CGC- > CGT).

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Article Synopsis
  • The study aimed to create a method to select HLA compatible platelets for patients experiencing immune platelet transfusion failure (IPTR) by combining two techniques: mean fluorescence intensity (MFI) grading and the HLAMatchmaker program for identifying donor-patient epitope mismatches.
  • Researchers conducted a comprehensive analysis involving 7,807 platelet (PLT) cross-matching tests and categorized MFI results into different positivity groups, allowing for a thorough evaluation of HLA Class I antibody levels in the patients.
  • Results showed significant differences in the positive reactions from the cross-matching tests, suggesting that the combined approach of avoiding high MFI threshold antigens and minimizing epitope mismatches effectively improves the
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Role of myeloid-derived suppressor cells in chronic brucellosis.

Front Cell Infect Microbiol

February 2024

Department of Transfusion Medicine, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou, China.

Introduction: Human brucellosis, a infection caused most common zoonosis in the world, remains a serious public health burden in China. chronic infection always causes immunosuppressive status and results in severe organ or tissue damages. The aim of this work was to study the role of the myeloid-derived suppressor cells (MDSCs) in human chronic brucellosis.

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Integrating single-cell datasets produced by multiple omics technologies is essential for defining cellular heterogeneity. Mosaic integration, in which different datasets share only some of the measured modalities, poses major challenges, particularly regarding modality alignment and batch effect removal. Here, we present a deep probabilistic framework for the mosaic integration and knowledge transfer (MIDAS) of single-cell multimodal data.

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Guadecitabine is a novel hypomethylating agent (HMA) resistant to deamination by cytidine deaminase. Patients with relapsed/refractory acute myeloid leukemia (AML) were randomly assigned to guadecitabine or a preselected treatment choice (TC) of high-intensity chemotherapy, low-intensity treatment with HMAs or low-dose cytarabine, or best supportive care (BSC). The primary end point was overall survival (OS).

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Objective: To develop a genotyping method for the Junior blood type and report on a rare blood type with Jr(a-).

Methods: Healthy O-type RhD+ volunteer donors of the Shenzhen Blood Center from January to May 2021 (n = 1 568) and a pedigree with difficult cross-matching (n = 3) were selected as the study subjects. Serological methods were used for proband's blood type identification, unexpected antibody identification, and antibody titer determination.

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[Genetic analysis of a Chinese pedigree with an allele dropout at the HLA-B locus].

Zhonghua Yi Xue Yi Chuan Xue Za Zhi

January 2024

Institute of Transfusion Medicine, Shenzhen Blood Center, Shenzhen, Guangdong 518020, China.

Article Synopsis
  • The study aims to identify a deletion mutation in the HLA-B gene within a Chinese family with a patient suffering from acute myeloid leukemia.
  • Methods used include PCR techniques for routine HLA testing and next-generation sequencing (NGS) for confirming genetic variants.
  • Results revealed inconsistencies in HLA-B typing between the patient and her daughter, ultimately identifying a 9 bp deletion in the HLA-B gene that impacted PCR-SBT accuracy.
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In December 2022, the Omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) became dominant in China due to its high infectivity and lower mortality rate. The risk of critical illness and mortality among patients with hematologic malignancies who contracted SARS-CoV-2 was particularly high. The aim of this study was to draft a consensus to facilitate effective treatments for these patients based on the type and severity of the disease.

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Serological assays for differentiating natural COVID-19 infection from vaccine induced immunity.

J Clin Virol

February 2024

School of Public Health, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China; Centre for Immunology and Infection(C2i), Hong Kong Science Park, Hong Kong SAR, China. Electronic address:

Background: Natural SARS-CoV-2 infection may elicit antibodies to a range of viral proteins including non-structural protein ORF8. RNA, adenovirus vectored and sub-unit vaccines expressing SARS-CoV-2 spike would be only expected to elicit S-antibodies and antibodies to distinct domains of nucleocapsid (N) protein may reliably differentiate infection from vaccine-elicited antibody. However, inactivated whole virus vaccines may potentially elicit antibody to wider range of viral proteins, including N protein.

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Sociodemographic Factors Related to Adverse Donor Reactions in Shenzhen.

Int J Gen Med

November 2023

Business Management Department, Shenzhen Blood Center, Shenzhen, People's Republic of China.

Background: The adverse donor reaction (ADR) means the uncomfortable feeling felt by blood donors during the whole process of blood donation, which can affect the blood donation behavior of blood donors. So, it is very necessary for blood centers to monitor and prevent it.

Methods: Data about ADRs in Shenzhen Blood Center from January 2018 to December 2022 were collected, and correlation analysis was conducted using SPSS 24.

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Article Synopsis
  • HLA-A*30:211 is a variation of the HLA-A*30:01:01:01 gene.
  • The difference between these two versions is due to a single nucleotide change.
  • Specifically, at nucleotide position 344 in exon 3, the nucleotide changes from G to C.
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HLA-A*02:1103 differs from HLA-A*02:01:01:01 by one nucleotide change at nucleotide 811 in exon 4 from G to A.

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The novel HLA-A*33:244 allele contains a c.553G>A substitution in exon 3 compared with A*33:03:01:01.

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[Polymorphism of the Full-Length mRNA Sequences of MNS blood group-related genes , and ].

Zhongguo Shi Yan Xue Ye Xue Za Zhi

October 2023

Institute of Blood Transfusion Medicine, Shenzhen Blood Center, Shenzhen 518000, Guangdong Province, China. E-mail:

Objective: The characteristics of the full-length mRNA sequences of MNS blood group-related genes , and were analyzed to understand the polymorphism of MNS blood group genes.

Methods: Anticoagulated blood within 24 h from 500 unpaid blood donors (8 ml each) were randomly selected, and MN, Ss and Mia blood types were identified by serological methods. 5 samples with different combinations of MNS and Mia blood types were randomly selected from 500 samples, and peripheral blood mononuclear cells (PBMC) were isolated by density gradient centrifugation, then total mRNA was extracted.

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Article Synopsis
  • Scientists tested if special brain cells, called neural precursor cells (NPCs), could help mice with strokes, especially those with high cholesterol.
  • They found that giving NPCs to the mice reduced damage in the brain right after the stroke but caused some bad side effects, like bleeding and more immune cells in mice with high cholesterol.
  • In the long run, NPCs helped the mice recover a little at first but didn't have lasting benefits on their brain or health later on.
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Background: Reduced survival of red blood cells (RBCs) in patients with chronic kidney disease (CKD) is thought to contribute to renal anaemia. Although renal anaemia improved greatly because of the wide use of erythropoiesis-stimulating agents (ESAs) and the advancement of dialysis techniques, RBC longevity seems not to be obviously ameliorated.

Methods: In this single-centre, single-arm trial, patients who had been undergoing haemodialysis and ESA therapy with epoetin alfa for at least 12 weeks changed their anti-anaemia drugs from epoetin alfa to oral roxadustat three times per week for 24 weeks.

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To investigate the application value of augmented reality navigation combined with indocyanine green(ICG) fluorescence imaging technology in laparoscopic anatomical segment 8 liver resection. Clinical and pathological data from 8 patients with hepatocellular carcinoma located in segment 8 of the liver admitted to the First Department of Hepatobiliary Surgery,Zhujiang Hospital,Southern Medical University from October 2021 to October 2022 were collected restrospectively. Among them,there were 5 males and 3 females,aged between 40 and 72 years.

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A small percentage of couples who regularly donated blood in China tested positive for HBsAg. Although it is well known that blood donors can acquire hepatitis B virus (HBV) infection from a chronically infected sexual partner, the prevalence of occult hepatitis B infections (OBIs) among blood donations from partners of HBV-infected chronically infected spouses and the risk to blood safety remain poorly understood. Among 212 763 blood donors, 54 pairs of couples (108 donations) were enrolled because one partner tested positive for HBsAg.

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Association between genetic predisposition and disease burden of stroke in China: a genetic epidemiological study.

Lancet Reg Health West Pac

July 2023

State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Background: Stroke ranks second worldwide and first in China as a leading cause of death and disability. It has a polygenic architecture and is influenced by environmental and lifestyle factors. However, it remains unknown as to whether and how much the genetic predisposition of stroke is associated with disease burden.

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Article Synopsis
  • Tumor size (TS) impacts intraoperative outcomes in laparoscopic major hepatectomy (L-MH), with this study aiming to clarify its effects and find optimal TS cutoffs for assessing surgical difficulty.
  • The analysis, which included 1396 patients from a larger pool of 3008 undergoing L-MH, identified two critical TS cutoffs at 50 mm and 100 mm that segmented patients into three distinct groups.
  • Results showed that larger TS correlated with increased open conversion rates, longer operation times, higher blood loss, and more intraoperative blood transfusions, while postoperative complications remained similar across the groups.
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HLA-B*13:179 differs from HLA-B*13:99 by one nucleotide substitution at position 829(A>G) in exon 4.

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