PPAR beta/gamma mediates the antihypertensive activity of a synbiotic preparation of and in spontaneous hypertensive rats.

Background: Hypertension is a global public health concern. A synbiotic preparation containing and has been used as adjunct therapy for hypertension. We sought to elucidate the antihypertensive activity of this preparation and explore the underlying mechanisms.

Antinociceptive iridoid glycosides from the aerial parts of .

Two previously undescribed iridoid glycosides, 6'--trans-feruloyl-(4,6)-3,4-dihydro-3-ethoxypaederoside () and 6'--trans-caffeoyl-(4,6)-3,4-dihydro-2'--3-paederoside (), were isolated from the 90% EtOH extract of the air dried aerial parts of . Structural elucidation of all the compounds was performed by spectral methods such as 1D and 2D (HH COSY, HMQC, and HMBC) NMR spectroscopy. The two isolated iridoid glycosides were tested for their antinociceptive properties.

Antibacterial lanostane triterpenoids from .

A phytochemical investigation on the 80% EtOH extract of the fruiting bodies of resulted into the isolation of two previously undescribed lanostane triterpenoids, 7,11-dioxo-3-acetyloxy-26,27-dihydroxy-lanosta-8,24-diene () and 7,20-dioxo-3-acetyloxy-1115-dihydroxy-22,23,24,25,26,27-hexanorlanosta-8-ene (), togeher with one known lanostane triterpenoid ganodermanontriol (). Structural elucidation of all the compounds were performed by spectral methods such as 1D and 2D (HH COSY, HMQC, and HMBC) NMR spectroscopy. All the triterpenoids were evaluated for their antibacterial activities against six pathogenic microorganisms.