1 results match your criteria: "Shengli Oilfeld Central Hospital[Affiliation]"
Low molecular weight heparins promote migration and invasion of trophoblast cells through regulating the PI3K/AKT signaling pathway.
Naunyn Schmiedebergs Arch Pharmacol
November 2024
Department of Obstetrical, Shengli Oilfeld Central Hospital, 31 Jinan Road, DongyingShandong, 257000, China.
Article Synopsis
- Preeclampsia (PE) poses serious risks to pregnant women and newborns, and low molecular weight heparins (LMWHs) are explored for their potential therapeutic benefits.
- LMWHs demonstrated a reduction in blood pressure, proteinuria, and trophoblast cell apoptosis in rat models of PE, suggesting they may alleviate symptoms of the condition.
- The study also uncovered that LMWHs activate the PI3K/AKT signaling pathway, providing a molecular mechanism for their protective effects against PE.