Differential Strigeid Infection Patterns in Male Morphotypes of Bluegill Sunfish (Lepomis macrochirus).

Purpose: Behavioral variation among conspecific organisms can have substantial ecological impacts, particularly affecting parasite infection. Bluegill sunfish (Lepomis macrochirus) exhibit multiple male reproductive morphotypes that differ in their size, feeding dynamics, and reproductive behavior. This study investigated how these morphological and ecological differences contribute to the patterns of infection by strigeid trematodes.

Socioeconomic and Health-Related Factors Affecting Congestive Heart Failure Readmissions.

Congestive heart failure (CHF) readmissions are frequent and costly but preventable. The purpose of this study was to analyze socioeconomic and health-related factors of CHF readmissions by examining the relationship between 30-day readmissions of individuals with CHF and their payer status, race, ethnicity, primary language spoken, living arrangement, and comorbidities. This retrospective case-control study used secondary data from 450 CHF patients admitted to a not-for-profit Northern Virginia hospital from July 2014 to December 2017.

Baricitinib Versus Tocilizumab for the Treatment of Moderate to Severe COVID-19.

Background: To date, minimal data directly compare tocilizumab with baricitinib for treatment in moderate to severe COVID-19.

Objective: To compare the rates of in-hospital mortality with progression to mechanical ventilation in patients with COVID-19 who received either tocilizumab or baricitinib.

Methods: The authors conducted a single-centered, institutional review board-approved, retrospective cohort study.

Setmelanotide: A Novel Targeted Treatment for Monogenic Obesity.

To review clinical data regarding the newly approved drug setmelanotide, an injectable melanocortin 4 receptor (MC4R) agonist, for chronic weight management in adults and children aged 6 years and older with monogenic obesity. A literature review was performed by searching MEDLINE, SCOPUS, and EMBASE for all relevant English-language articles published between January 1, 1996, and November 30, 2021, using search terms obesity, setmelanotide, Imcivree, and MC4R agonist. This review included two phase 2, two phase 3, and one ongoing clinical trial evaluating the efficacy and/or safety of setmelanotide.

Atogepant for the prevention of episodic migraine in adults.

Objective: Atogepant is a newly approved medication for the prevention of migraine. This review aims to discuss the efficacy, safety, cost, and place in therapy of atogepant.

Methods: The authors performed a systematic search for sources, including articles, abstracts, and poster presentations.

Evaluation of the early-stage entrepreneurship activity in the United States during the COVID-19 pandemic.

This paper examines the effects of the COVID-19 pandemic (measured by total cases and deaths per 100K people) on the early-stage entrepreneurship activity (measured by the Kauffman Early-Stage Entrepreneurship indicators) in the United States. The empirical analyses are based on the panel dataset of 51 States between 2020 and 2021. The findings show that the COVID-19 pandemic negatively affects early-stage entrepreneurship activity.

Considering medication exposure in genomic association studies of cognition in psychotic disorders.

Cognitive dysfunction is a core feature of psychosis-spectrum illnesses, and the characterization of related genetic mechanisms may provide insights regarding the disease pathophysiology. Substantial efforts have been made to determine the genetic component of cognitive symptoms, without clear success. Illness-related moderators and environmental factors such as medications hinder the detection of genomic association with cognition.

Financial Toxicity and Its Association With Prostate and Colon Cancer Screening.

Background: The term "financial toxicity" or "hardship" is a patient-reported outcome that results from the material costs of cancer care, the psychological impacts of these costs, and the coping strategies that patients use to deal with the strain that includes delaying or forgoing care. However, little is known about the impact of financial toxicity on cancer screening. We examined the effects of financial toxicity on the use of screening tests for prostate and colon cancer.

Reliability and discriminant validity of the quantitative timed up and go in typically developing children and children with cerebral palsy GMFCS levels I-II.

Purpose: The purpose of this study was to examine the reliability and discriminant validity of the Quantitative Timed up and Go (QTUG) in typically developing (TD) children and children with cerebral palsy (CP).

Methods: Twenty-eight TD children and 8 with CP (GMFCS I-II) completed 3 TUG trials while wearing QTUG sensors. Test-retest reliability and discriminative ability were examined for the 57 constituent parameters of the TUG.

Diversity in the Physician Assistant Pipeline: Experiences and Barriers in Admissions and PA School.

Introduction: The purpose of this study was to identify perceived barriers faced by physician assistant (PA) students who identified as an underrepresented minority in medicine (URM-med), sexual or gender minority (SGM), coming from low socioeconomic status (low SES), or a person with a disability (PWD).

Methods: More than 2700 PA students across the United States provided information regarding their PA school application process and program experiences. This study examined differences among URM-med, SGM, low SES, and PWD compared to those who were not in those groups to determine the relationship between these factors and student concerns about bias in the application process, as well as a variety of experiences in PA school.

Advances in Pain Medicine: a Review of New Technologies.

Purpose Of Review: This narrative review highlights the interventional musculoskeletal techniques that have evolved in recent years.

Recent Findings: The recent progress in pain medicine technologies presented here represents the ideal treatment of the pain patient which is to provide personalized care. Advances in pain physiology research and pain management technologies support each other concurrently.

Jump landing among chronic ankle instability individuals who did or did not attend rehabilitation at the time of injury.

Objectives: The purpose was to compare vertical ground reaction forces and sagittal-plane energy dissipation patterns of the lower extremity during a single-limb jump-stabilization task between individuals with chronic ankle instability who did or did not attend rehabilitation after their initial ankle sprain.

Design: Cross-sectional.

Setting: Research laboratory.

Once-Weekly Semaglutide for Weight Management: A Clinical Review.

To review the efficacy, safety, and role of the glucagon-like peptide-1 (GLP-1) receptor agonist semaglutide for chronic weight management. A literature search of PubMed/MEDLINE and Google Scholar was performed using the search terms: semaglutide 2.4, weight, and obesity.

Secular Trends in Risk Profiles Among Adults With Cardiovascular Disease in the United States.

Background: Documenting trends in risk factors among individuals with cardiovascular disease (CVD) may inform policy and secondary prevention initiatives.

Objectives: This study aimed to examine 20-year trends in risk profiles among U.S.

PharmVar GeneFocus: SLCO1B1.

The Pharmacogene Variation Consortium (PharmVar) is now providing star (*) allele nomenclature for the highly polymorphic human SLCO1B1 gene encoding the organic anion transporting polypeptide 1B1 (OATP1B1) drug transporter. Genetic variation within the SLCO1B1 gene locus impacts drug transport, which can lead to altered pharmacokinetic profiles of several commonly prescribed drugs. Variable OATP1B1 function is of particular importance regarding hepatic uptake of statins and the risk of statin-associated musculoskeletal symptoms.

Management of chronic musculoskeletal pain in an adult with Down syndrome using a modified pain neuroscience approach: a case report.

Background: The use of pain neuroscience education (PNE) in the management of chronic musculoskeletal pain is well documented in the literature for the adult population. However, the use of this component within the larger biopsychosocial approach has not been examined in adults with intellectual disabilities. The purpose of this case report is to describe the utilization of a PNE approach combined with exercise in the physical therapy management of chronic musculoskeletal pain in an adult with Down syndrome.

Global Capitalism as Blood Sacrifice: Mainstream American Comic Books and Depictions of Economic Inequality.

The past few decades have witnessed unprecedented global economic catastrophes that exacerbated pre-existing socioeconomic inequalities. Although many scholars have attributed the resulting social harms to the failures of neoliberal capitalism-and recognize it as criminogenic-the logics upholding the economic order continue to hold sway among the public. Given that these logics are commonly reinforced through media and popular culture narratives, in this paper we explore how economic inequalities are portrayed in American comic books.

A pilot psychedelic psychopharmacology elective.

Background And Purpose: There is renewed research attention on the use of psychedelic drugs to treat psychiatric illnesses. If psychedelic drugs are approved for medical use in the United States, patients, professionals, and policy makers will look to pharmacists as medication experts for advice on the safe, effective, and ethical use of these substances. To help prepare a future generation of pharmacists in this therapeutic area, a psychedelic psychopharmacology elective was developed and piloted.

PARASITISM IN HYBRID SUNFISH (LEPOMIS SPP.): PATTERNS OF INFECTION AT THE INDIVIDUAL AND COMMUNITY LEVEL.

Sunfish (Lepomis spp.) are among the most common piscine inhabitants of freshwater lakes and ponds in North America. Lepomis spp.

Relationships Between Resilience, Mental Well-Being, and COVID-19 Worries in Collegiate Student-Athletes.

The onset of the COVID-19 pandemic was associated with robust declines in well-being for collegiate student-athletes. Worries about COVID-19 have frequently been associated with worsening well-being; therefore, it is important to examine protective factors against well-being decrements. Resilience, one's ability to respond to stress and adversity, may be one such factor.

Corrigendum to: Do Stay at Home Orders and Cloth Face Coverings Control COVID-19 in New York City? Results From a SIER Model Based on Real-world Data.

[This corrects the article DOI: 10.1093/ofid/ofaa442.].

The impact of COVID-19 on health professions student's perceptions, future education and career aspirations and confidence in public health responses.

: To understand student perceptions, interest and intentions of pursuing public health as a result of COVID-19 during educational experiences. Two hundred seventy-seven students completed the survey representing 38 states and two countries. : An online survey was administered to current undergraduate and graduate students at two institutions.

The use of occupation based interventions among certified hand therapists.

Background: The effectiveness of occupation-based hand therapy and the barriers to the use of occupation-based interventions (OBIs) have been established, but the current experience of hand therapists using OBIs and the extent of the use of OBIs in practice is unknown.

Objective: This study aimed to identify the frequency that occupational therapists who are Certified Hand Therapists (CHTs) utilized OBIs, how occupational therapists who are CHTs described their application of OBIs, and identify the supports and barriers to the application of OBIs.

Methods: Twenty-nine participants completed a survey that included 27 questions.