954 results match your criteria: "Shared Psychotic Disorder"
Shared polygenic susceptibility to treatment response in severe affective and psychotic disorders: Evidence from GWAS data sets.
Prog Neuropsychopharmacol Biol Psychiatry
October 2024
Instituto de Investigación Sanitaria (IDIS) de Santiago de Compostela, Complexo Hospitalario Universitario de Santiago de Compostela (CHUS), Servizo Galego de Saúde (SERGAS), Santiago de Compostela, Galicia, Spain. Electronic address:
Article Synopsis
- The study investigates the genetic links between treatment-resistant schizophrenia (TRS), lithium response in bipolar disorder (BD), and antidepressant response in major depressive disorder (MDD).
- It employs the conditional/conjunctional false discovery rate (cond/conjFDR) methodology to identify shared genetic mechanisms that might influence treatment outcomes across these disorders.
- The findings suggest a significant genetic correlation, particularly highlighting the MAP2K1 gene as a shared locus, and indicate a need for future research with larger data sets to validate these results.
Management of schizophrenia and comorbid substance use disorders: expert review and guidance.
Ann Gen Psychiatry
October 2024
Institut Salut Mental Hospital del Mar, Hospital del Mar Research Institute. Universitat de Vic-UCC, Universitat Autònoma de Barcelona. Red de investigación en Atención Primaria de Adicciones (RIAPAd), Barcelona, Spain.
Article Synopsis
- Schizophrenia and substance use disorders (SUDs) often occur together, creating clinical challenges like poor mental health, low medication adherence, and high rates of relapse and hospitalization.
- This narrative review highlights the need for better diagnosis and treatment for patients with these comorbid conditions by examining current evidence and the healthcare system's management practices.
- Effective treatment should include both pharmacological options, such as partial dopamine agonists, and psychosocial support through an integrated approach that fosters collaboration among healthcare providers and patients.
Exploring Patient Empowerment in Major Depressive Disorder: Correlations of Trust, Active Role in Shared Decision-Making, and Symptomatology in a Sample of Italian Patients.
J Clin Med
October 2024
Psychiatry Unit, Department of Clinical and Experimental Medicine, University of Catania, 95124 Catania, Italy.
Article Synopsis
- - Empowerment in psychiatry is about patients actively participating in their health decisions, which can lead to better treatment outcomes, especially important in mental health due to issues like stigma and cognitive challenges.
- - A study involving 73 patients with Major Depressive Disorder found no significant links between decision-making involvement and perceived empowerment, nor between trust in psychiatrists and empowerment; however, higher depression severity correlated with lower empowerment.
- - The results indicate that simply having trust or involvement in decision-making may not enhance empowerment; instead, it suggests that higher empowerment correlates with lower depression levels, highlighting the complexity of patient engagement in mental health care.
Psychopathology, psychopathy, body management, and undoing in youthful parricide offenders.
J Forensic Sci
October 2024
OmaDesala Psychiatric Services, Ewing, New Jersey, USA.
Article Synopsis
- - The study analyzed 21 youthful parricide offenders (ages 11-21) to explore links between mental health issues, psychopathy levels, and specific behaviors related to how they handled their victims' bodies after committing murder, focusing on "body movement" and "body alteration."
- - One interesting finding was that one-third of the offenders engaged in "undoing" behaviors, motivated by psychological needs rather than practical reasons, yet those with a history of child abuse didn't show more of these behaviors compared to non-abused youth; many had high psychopathy levels.
- - The research also noted that none of the youth with psychotic symptoms exhibited body management behaviors, and there was a clear distinction between how they and their non
Exploring the role of TNF-α, TGF-β, and IL-6 serum levels in categorical and noncategorical models of mood and psychosis.
Sci Rep
October 2024
Faculty of Medicine, University of Belgrade, Dr Subotica 8, 11000, Belgrade, Serbia.
Article Synopsis
- Psychotic and mood disorders are interconnected, suggesting that they may exist on a continuum rather than as separate categories.
- A study on 143 patients with schizophrenia and bipolar disorder revealed that lower levels of the cytokine TGF-β were linked to more severe symptoms and a higher likelihood of psychotic episodes.
- The findings suggest that immune dysregulation, particularly involving TGF-β, could play a shared role in both disorders, which may influence how we classify and understand their clinical presentations.
Article Synopsis
- Delusional parasitosis is a psychotic disorder where individuals believe they are infested with parasites, while shared paranoid disorder (folie à deux) occurs when two closely related people share similar delusions.
- A case study involving a married couple revealed that the husband experienced sensations and beliefs about parasites, leading to the wife also developing similar symptoms, indicating a shared delusion.
- Treatment included medications like sertraline and risperidone, but due to side effects and financial constraints, the husband's condition required adjustments, and separating the couple's sleeping arrangements significantly alleviated the wife's symptoms.
Shared Delusion: Impact on the Parent-Child Relationship.
Cureus
August 2024
Department of Medicine, Nova Southeastern University Dr. Kiran C. Patel College of Osteopathic Medicine, Fort Lauderdale, USA.
Article Synopsis
- Folie à famille, or shared psychotic disorder among family members, is a rare psychiatric condition that is often overlooked and can significantly affect parent-child relationships.
- Most existing research focuses on adults, leaving a knowledge gap regarding how this disorder impacts children and family dynamics.
- A case study of a school-aged girl with autism illustrates the challenges of diagnosing shared psychosis in children, highlighting the need for tailored treatment strategies that consider both psychopharmacological and therapeutic approaches.
Development and validation of a Disorganised Thoughts Scale: a new measure to assess thinking difficulties in the general population.
BMC Psychol
September 2024
MAIC/UniSC Road Safety Research Collaboration, School of Law and Society, University of the Sunshine Coast, 90 Sippy Downs Dr, Sippy Downs, Queensland, 4556, Australia.
Article Synopsis
- Disordered thinking affects both clinical cases and the general population, but there is currently no effective way to measure it, prompting the development of the Disorganised Thoughts Scale (DTS).
- A survey was conducted with various groups, including a large sample from Australia, to evaluate the DTS using statistical methods that confirmed its internal and external validity.
- Results indicated that the DTS effectively captures two types of disorganized thinking: Positive (accelerated, uncontrollable) and Negative (inhibited, disjointed), and it correlates well with other cognitive measures, particularly in individuals experiencing psychological distress and substance use.
Genetic overlap between schizophrenia spectrum disorders and Alzheimer's disease: Current evidence and future directions - An integrative review.
Neurosci Biobehav Rev
December 2024
Department of Psychiatry, Gifu University Graduate School of Medicine, Gifu, Japan.
Article Synopsis
- * Patients with schizophrenia or delusional disorder, especially older women, are at a higher risk for developing Alzheimer's, while a significant percentage of Alzheimer's patients experience psychotic symptoms that can worsen their condition.
- * The review highlights weak genetic correlations between schizophrenia and Alzheimer's, pointing out inconsistencies in polygenic risk scores, and underscores the need for further research into their genetic links and impacts on treatment and prevention strategies.
Association Between Juvenile Psychotic Experiences and Problematic Gaming.
Schizophr Bull Open
January 2024
Department of Psychiatry, Federal University of São Paulo (Unifesp), São Paulo, Brazil.
Article Synopsis
- Problematic gaming (PG) is a mental health issue linked to negative outcomes, with a focus on its potential connection to psychotic experiences (PE), which is not well-researched.
- A study conducted with a large group of Brazilian adolescents (ages 13-21) revealed that those with PG reported higher levels of PE compared to those without PG, even after controlling for other factors like psychiatric disorders.
- The findings suggest that there may be shared underlying mechanisms between PG and PE, indicating a need for further research in this area.
Electroconvulsive therapy response and remission in moderate to severe depressive illness: a decade of national Scottish data.
Br J Psychiatry
September 2024
School of Medicine, University of Dundee, Dundee, UK.
Article Synopsis
- - **ECT Efficacy**: Electroconvulsive therapy (ECT) shows a high effectiveness for treating moderate to severe depression, achieving a 73% response rate and a 51% remission rate among patients between 2009 and 2018 in Scotland.
- - **Predictive Factors**: Key factors influencing ECT response and remission include older age, presence of psychotic symptoms, previous treatment successes, medication resistance, and history of recurrent depression, helping to identify which patients might benefit the most from ECT.
- - **Machine Learning Application**: A predictive model using machine learning can identify potential remission with 61% accuracy, aiding in better treatment decisions, reducing unnecessary ECT treatments, and promoting timely interventions when
The effects of ketogenic metabolic therapy on mental health and metabolic outcomes in schizophrenia and bipolar disorder: a randomized controlled clinical trial protocol.
Front Nutr
August 2024
Laboratory of Psychiatric Neurosciences, Australian Institute of Tropical Health and Medicine, College of Public Health, Medical and Veterinary Science, James Cook University, Townsville, QLD, Australia.
Article Synopsis
- Schizophrenia, schizoaffective disorder, and bipolar disorder are serious mental illnesses associated with emotional, cognitive, and behavioral issues, leading to major health problems and reduced life expectancy.
- The study aims to test the effectiveness of a modified ketogenic diet over 14 weeks for improving symptoms in patients with these disorders, compared to a standard healthy eating diet.
- Key outcomes will focus on changes in psychiatric symptoms and cognitive function, as well as metabolic health measures.
Polygenic Risk Scores and Twin Concordance for Schizophrenia and Bipolar Disorder.
JAMA Psychiatry
December 2024
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Article Synopsis
- Schizophrenia and bipolar disorder are heritable psychiatric conditions; this study aims to explore how genetic factors, specifically polygenic risk scores (PRS), influence psychosis among twins.* -
- Using data from the Schizophrenia and Bipolar Twin Study and the Swedish Twin Registry, researchers analyzed twin pairs to see if those with higher PRS had increased likelihood of psychosis.* -
- The final analysis included over 300 twin pairs, assessing psychosis through clinical interviews, with the goal of determining the heritability of psychosis and understanding genetic overlap between the two disorders.*
Trajectories of Inflammation in Youth and Risk of Mental and Cardiometabolic Disorders in Adulthood.
JAMA Psychiatry
November 2024
Institute for Mental Health, School of Psychology, University of Birmingham, Birmingham, United Kingdom.
Article Synopsis
- Research indicates that ongoing low-grade inflammation may be a precursor to mental and physical health issues in adulthood, but most evidence has been limited to specific disorders or cross-sectional studies.
- The study aimed to analyze inflammation patterns in children and adolescents using C-reactive protein (CRP) levels and assess their connections to mental and cardiometabolic health outcomes in early adulthood.
- Out of 6,556 participants, three distinct inflammation trajectories were identified: persistently low, early peak at age 9, and late peak at age 17, with the early peak group showing a significantly higher risk for psychotic disorders.
Psychiatric Disorders During Pregnancy and Postpartum Period: A Guide For Perinatal Interview.
Eurasian J Med
December 2023
Department of Psychiatry, Sakarya University Faculty of Medicine, Sakarya, Türkiye.
Article Synopsis
- - Pregnancy and the year after birth are critical times for monitoring and treating mental health issues, as conditions like depression, anxiety, bipolar disorder, and psychotic disorders often arise during this period.
- - Treatment begins with a perinatal interview, focusing on a thorough examination of the patient's situation and collaborative decision-making about treatment options and their potential risks and benefits.
- - Mental health issues during this time can negatively impact both the mother's health and the baby's development, and many studies indicate that the benefits of using most psychiatric medications outweigh the risks of leaving mental illnesses untreated.
Problematic use of Internet in a sample of psychiatric outpatients: preliminary observations from the "real world".
Riv Psichiatr
July 2024
Psychiatry and Clinical Psychopharmacology Unit, A. Fiorini Hospital, Local Health Department of Latina, Terracina (LT), Italy - Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy.
Article Synopsis
- The study investigates Problematic Use of Internet (PUI) and its relationship to mental health issues among 143 psychiatric outpatients, finding that the prevalence of PUI ranges from 1% to 25% depending on the assessment tool used.
- Results indicate that PUI is significantly associated with age, and higher in students, with correlations to personality and eating disorders, as well as other addictions like alcohol and substance use.
- The authors suggest further research on PUI among students and endorse the need for awareness among healthcare providers and educators about the risks linked to PUI and its potential shared pathophysiology with other addiction disorders.
Interaction between visual impairment and genetic risk of dementia and psychosis in older adults.
Age Ageing
July 2024
Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Article Synopsis
- Visual impairment (VI) is linked to dementia, depression, and hallucinations in older adults, but previous research didn't account for genetic influences.
- A comprehensive analysis using data from the Health and Retirement Study found that while VI consistently correlated with dementia and depression, the link with hallucinations varied based on genetic risk for schizophrenia.
- Specifically, high genetic risk increased the association between VI and hallucinations, showing that genetics do not fully explain the neuropsychiatric outcomes related to VI in older adults.
Monitoring momentary subjective well-being and psychotic experiences during antipsychotic dose reduction: Two single-case time series experience sampling method pilot study.
Psychiatr Rehabil J
December 2024
Geestelijke Gezondheidszorg Eindhoven, Institute of Mental Health Care.
Article Synopsis
- The study aimed to assess if a smartphone app using experience sampling methods (ESM) could help monitor changes in subjective well-being and psychotic experiences during the reduction of antipsychotic medication doses in two participants with psychotic disorders.
- Results revealed varied effects: one participant showed improved well-being and fewer psychotic experiences, while the other experienced worsened conditions during the dose reduction.
- The findings suggest that self-monitoring through the ESM app can empower individuals, enhance their control over their treatment, and aid in optimizing medication dosages tailored to personal experiences, essential in managing diverse psychotic disorders.
Levodopa-responsive dystonia, parkinsonism, and treatment-resistant schizoaffective disorder in Williams syndrome.
Neurol Sci
July 2024
Institute of Medical Science, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
Article Synopsis
- Williams syndrome (WS) is a rare genetic disorder linked to chromosome 7, characterized by developmental delays and various neuropsychiatric issues, including movement disorders and psychiatric conditions.
- The study presents two adult cases of WS with severe treatment-resistant schizoaffective disorder and associated movement issues, such as parkinsonism and dystonia, observed after clozapine treatment.
- The findings suggest that low-dose levodopa may effectively alleviate movement symptoms without worsening psychotic or mood symptoms, indicating new potential treatment avenues for individuals with WS.
Neurostructural subgroup in 4291 individuals with schizophrenia identified using the subtype and stage inference algorithm.
Nat Commun
July 2024
Institute of Science and Technology for Brain Inspired Intelligence, Fudan University, Shanghai, China.
Article Synopsis
- This study used machine learning to classify subtypes of schizophrenia by analyzing brain images from over 4,000 patients and healthy individuals through international collaboration.* -
- Researchers identified two neurostructural subgroups: one with predominant cortical loss and enlarged striatum, and another with significant subcortical loss in areas like the hippocampus and striatum.* -
- The findings suggest this new imaging-based classification could redefine schizophrenia based on biological similarities, enhancing our understanding and treatment of the disorder.*
Independent inheritance of cognition and bipolar disorder in a family sample.
Am J Med Genet B Neuropsychiatr Genet
January 2025
Intramural Research Program, National Institute of Mental Health, NIH, DHHS, Bethesda, Maryland, USA.
Cognitive deficits in people with bipolar disorder (BD) may be the result of the illness or its treatment, but they could also reflect genetic risk factors shared between BD and cognition. We investigated this question using empirical genetic relationships within a sample of patients with BD and their unaffected relatives. Participants with bipolar I, II, or schizoaffective disorder ("narrow" BD, n = 69), related mood disorders ("broad" BD, n = 135), and their clinically unaffected relatives (n = 227) completed five cognitive tests.
View Article and Find Full Text PDFInteraction between RNF4 and SART3 is associated with the risk of schizophrenia.
Heliyon
June 2024
Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Article Synopsis
- * Researchers found higher mRNA levels of RNF4 and SART3 in SCZ patients compared to controls and identified specific genetic variants (SNPs) related to increased SCZ risk.
- * Experiments suggested that SART3 regulates RNF4 expression through ubiquitination, indicating a potential shared mechanism influencing SCZ risk, which could help in developing new treatment strategies.
The risks for major psychiatric disorders in the siblings of probands with major depressive disorder.
Mol Psychiatry
January 2025
Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA.
Article Synopsis
- - The study analyzed siblings of individuals with major depression (MD) alongside control groups to examine the familial risks and clinical features of MD over several decades.
- - Results revealed a correlation (0.20) between MD in probands and their siblings, with factors like early age of onset, number of depressive episodes, and various psychiatric conditions increasing the risk of MD among siblings.
- - Siblings of MD probands showed significantly elevated risks for various disorders, including ADHD, anxiety disorders, and bipolar disorder, suggesting that familial liability for MD is influenced by genetic factors and overlaps with a range of psychiatric illnesses.
Neuroretinal Alterations in Schizophrenia and Bipolar Disorder: An Updated Meta-analysis.
Schizophr Bull
August 2024
Department of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Article Synopsis
- Schizophrenia (SZ) and bipolar disorder (BD) show significant changes in symptoms, cognition, and brain structure, leading researchers to investigate their retinal changes using optical coherence tomography (OCT).
- A total of 39 studies were analyzed, including data from 3145 patient eyes (1956 SZ, 1189 BD) and 3135 healthy control eyes, revealing retinal nerve fiber layer thinning in both disorders, but differing patterns of structural changes between SZ and BD.
- The analysis also found moderating factors like age, illness duration, and smoking influence retinal structures, underscoring the importance of examining these specific retinal abnormalities in relation to psychotic disorders.