The causal association between serum metabolites and lung cancer based on multivariate Mendelian randomization.

This study seeks to understand the causal association between serum metabolites and different lung cancer types, an area yet to be extensively studied. We Used a two-sample Mendelian randomization (TSMR) approach, utilizing 486 blood metabolites as exposures and 3 distinct lung cancer types genome-wide association studies datasets as outcomes. We employed inverse variance weighting, MR-Egger, weighted median, simple mode, and weighted mode to estimate causal effects.

Study on nonlinear dynamic characteristics of a two-speed transmission system at low speed.

A pure shear mechanical model of low gear of six-degree-of-freedom two-speed transmission system is established by using lumped parameter method. The Runge-Kutta method is used to numerically solve the aforementioned nonlinear system. The variation of transmission error between gears is analyzed by using global bifurcation, time domain diagram, phase diagram and Poincare cross section.

Germline Mutations of Holliday Junction Resolvase Genes in Multiple Primary Malignancies Involving Lung Cancer Lead to PARP Inhibitor Sensitization.

Purpose: The incidence of multiple primary malignancies (MPM) involving lung cancer has increased in recent decades. There is an urgent need to clarify the genetic profile of such patients and explore more efficacious therapy for them.

Experimental Design: Peripheral blood samples from MPM involving patients with lung cancer were assessed by whole-exome sequencing (WES), and the identified variants were referenced for pathogenicity using the public available database.

Rasch analysis of Morse Fall Scale among the older adults with cognitive impairment in nursing homes.

This is a cross-sectional study to investigate the efficacy of Morse Fall Scale (MFS) in nursing homes for older adults with cognitive impairment. According to Rasch analysis, the person separation index was 0.95 (person reliability 0.

Characteristics, hotspots, and prospects of short video research: A review of papers published in China from 2012 to 2022.

In recent years, due to the increase in their global popularity, short video applications have become an important topic of research. The number of users has now exceeded one billion in China; accordingly, Chinese researchers have conducted many studies on short videos. Their findings can serve as important references for both theoretical research on and the practical development of short videos worldwide.

Molecular mechanisms of DNase inhibition of early biofilm formation or : A transcriptome analysis.

studies show that DNase can inhibit and biofilm formation. However, the underlying molecular mechanisms remain poorly understood. This study used an RNA-sequencing transcriptomic approach to investigate the mechanism by which DNase I inhibits early and biofilm formation on a transcriptional level, respectively.

Worldwide productivity and research trend on fruit quality: a bibliometric study.

Introduction: As one of the important sources of food for human beings, fruits have been extensively studied. To better guide basic and applied research, it is urgent to conduct a systematic analysis of these studies based on extensive literature collection.

Methods: Based on the Web of Science Core Collection database, this study uses R language and CiteSpace to conduct bibliometric analysis and data mining on the literatures related to fruit quality from January 2013 to June 2023.

The anisotropic transport properties of the three-terminal ballistic junction based on-lattice.

The three-terminal ballistic junction (TBJ) has promising applications in nanoelectronics. We investigate the transport properties of a--based TBJ, where two typical configurations are considered, i.e.

n6-methyladenosine-modified circular RNA family with sequence similarity 126, member A affects cholesterol synthesis and malignant progression of prostate cancer cells by targeting microRNA-505-3p to mediate calnexin.

Prostate cancer (PCa) is the most commonly diagnosed malignancy in men. In tumor biology, n6-methyladenosine (m6A) can mediate the production of circular RNAs (circRNAs). This study focused on the mechanism of m6A-modified circRNA family with sequence similarity 126, member A (FAM126A) in PCa.

Insights in Electrochemical Determination of Quercetin in Peach Vinegar by the Hexagonal Platinum Nanocrystal.

Peach vinegar is a popular condiment that is thought to have various health benefits. However, the low levels of quercetin and complex detection environment in peach vinegar make it difficult to detect using traditional methods. Electrochemical detection is a promising solution because it is sensitive, inexpensive, and provides real-time results.

Esketamine enhances memory reconsolidation in the novel object recognition task.

Esketamine, the right-handed optical isomer of racemic ketamine, is a rapidly acting antidepressant approved by the FDA for treatment-resistant depression in 2019. However, few studies have investigated esketamine's role in learning and memory, particularly in the context of memory reconsolidation. Herein, we evaluated esketamine's role in memory reconsolidation in 7-week-old male Institute of Cancer Research mice subjected to the novel object recognition (NOR) memory task.

Study of Helicobacter pylori infection in patients with chronic atrophic gastritis and its relationship with lifestyle habits and dietary nutrient intake: A retrospective analysis.

To explore Helicobacter pylori (Hp) infection status and its relationship with lifestyle habits and dietary factors in patients with chronic atrophic gastritis. Six hundred thirty-eight patients with chronic atrophic gastritis, who were admitted to our hospital from March 2021 to April 2023, were selected for the study. All patients underwent the 13C urea breath test.

Pan-Cancer Analysis of P3H1 and Experimental Validation in Renal Clear Cell Carcinoma.

Prolyl 3-hydroxylase 1 (P3H1) has been implicated in cancer development, but no pan-cancer analysis has been conducted on P3H1. In this study, for the first time, aspects associated with P3H1, such as the mRNA expression, any mutation, promoter methylation, and prognostic significance, the relationship between P3H1 and clinicopathological parameters, drug sensitivity, and immune cell infiltration were investigated by searching several databases including The Cancer Genome Atlas (TCGA), Genotype-Tissue Expression (GTEx), cBioPortal, and The Tumor Immune Evaluation Resource (TIMER2.0) using bioinformatics tools.

The association between anterior cruciate ligament degeneration and incident knee osteoarthritis: Data from the osteoarthritis initiative.

Background: Though anterior cruciate ligament (ACL) tear has been widely accepted as an important accelerator for knee osteoarthritis (KOA), the role of intrinsic ACL degeneration in developing KOA has not been fully investigated.

Purpose: To determine whether ACL degeneration, in the absence of ACL tear, is associated with incident KOA over 4 years.

Study Design: Cohort study; Level of evidence, 2.

Calcined Bean Dregs-Hydrocalumite Composites as Efficient Adsorbents for the Removal of Ofloxacin.

Calcined bean dregs-hydrocalumite composites were prepared through in situ self-assembly of hydrocalumite on the surface of bean dregs and used for the adsorption of ofloxacin from water. The adsorbents were characterized by scanning electron microscopy, X-ray powder diffraction, and N physical adsorption. The results showed that the adsorption performance of calcined bean dregs-hydrocalumite composites for ofloxacin was much better than that of a single bean dreg carbon or calcined hydrocalumite.

Pulsed-control plasma-activated water: An emerging technology to assist ultrasound for fresh-cut produce washing.

In this study, we explored the use of plasma-activated water (PAW) in combination with ultrasound (US) for food disinfection. Our research introduces a novel approach that utilizes a pulsed-control (PC) method to modify the PAW. The resulting PCPAW exhibits significantly higher concentrations of key reactive oxygen and nitrogen species (RONS) compared to conventional PAW.

Effects of Reduction Methods on the Performance of MR-1 Palladium/Carbon Catalyst for Oxygen Reduction Reaction.

The influence of the reduction method on the morphology and performance of the catalyst still controversial. In this study, hydrogen, MR-1 (MR-1), MR-1 and hydrogen coreduction are used to reduce the palladium ions adsorbed by MR-1 to obtain Pd/C, Pd/C, and Pd/C catalyst, respectively. It is found that the palladium nanoparticles (Pd NPs) in Pd/C are the largest, while the Pd NPs in Pd/C are the smallest.

Effect of calcium ion concentration on the ORR performance of Pd/C catalysts.

Noble metal electrocatalysts prepared by microbial methods have attracted extensive attention because of their environmental protection and easy preparation. However, the preparation of electrocatalysts by microbial methods has problems such as large nanoparticles size and low loading rate. In this study, the porous gel co-embedded with and alginate is prepared as the adsorption matrix to further enhance its mass transfer and adsorption efficiency.

Ferroptosis: opening up potential targets for gastric cancer treatment.

The fifth most frequent cancer in the world is gastric cancer. It ranks as the fourth most common reason for cancer-related deaths. Even though surgery is the only curative treatment for stomach cancer, adding adjuvant radiotherapy and chemotherapy is preferable than only surgery.

Mechanisms connecting square dance to sleep quality among middle-aged and older Chinese females: serial mediation roles of social support and depressive symptoms.

Background: Square dance is gaining increasing popularity among middle-aged and older Chinese women who are also at high risk of sleep disturbance. Although previous studies have shown exercise could improve sleep quality, the association between square dance and sleep quality remains to be discussed, and even less is known about the potential mechanism underlying this association.

Purpose: This study aims to investigate the relationship between square dance and sleep quality and test if social support and depressive symptoms together play a serial mediating role in the influence of square dance on sleep quality.

FeO/carbon-decorated graphene boosts photothermal conversion and storage of phase change materials.

Pristine organic phase change materials (PCMs) are difficult to complete photothermal conversion and storage. To upgrade their photothermal conversion and storage capacity, we developed Fe-MOF (metal-organic framework) derived FeO/C-decorated graphene (GP) based composite PCMs toward solar energy harvesting. Graphene is an excellent phonon conductor, and FeO/C-GP as a photon capturer exhibits strong full-spectrum absorption.

From Lidar Measurement to Rotor Effective Wind Speed Prediction: Empirical Mode Decomposition and Gated Recurrent Unit Solution.

Conventional wind speed sensors face difficulties in measuring wind speeds at multiple points, and related research on predicting rotor effective wind speed (REWS) is lacking. The utilization of a lidar device allows accurate REWS prediction, enabling advanced control technologies for wind turbines. With the lidar measurements, a data-driven prediction framework based on empirical mode decomposition (EMD) and gated recurrent unit (GRU) is proposed to predict the REWS.

Single-cell histone chaperones patterns guide intercellular communication of tumor microenvironment that contribute to breast cancer metastases.

Background: Histone chaperones (HCs) are crucial for governing genome stability and gene expression in multiple cancers. However, the functioning of HCs in the tumor microenvironment (TME) is still not clearly understood.

Methods: Self-tested single-cell RNA-seq data derived from 6 breast cancer (BC) patients with brain and liver metastases were reanalyzed by nonnegative matrix factorization (NMF) algorithm for 36 HCs.

6mA-StackingCV: an improved stacking ensemble model for predicting DNA N6-methyladenine site.

DNA N6-adenine methylation (N6-methyladenine, 6mA) plays a key regulating role in the cellular processes. Precisely recognizing 6mA sites is of importance to further explore its biological functions. Although there are many developed computational methods for 6mA site prediction over the past decades, there is a large root left to improve.