1 results match your criteria: "Shanxi University Taiyuan 030006 P. R. China wkyqli@sxu.edu.cn.[Affiliation]"
pH-Sensitive nanodiamond co-delivery of retinal and doxorubicin boosts breast cancer chemotherapy.
RSC Adv
September 2023
Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Institute of Molecular Science, Shanxi University Taiyuan 030006 P. R. China
Article Synopsis
- This study utilizes nanodiamonds (NDs) to covalently bind all-trans retinal (NPA) for controlled drug release based on pH levels, allowing for a dual drug system with doxorubicin (DOX) integrated.
- NPA@D showed significant cytotoxic effects against MCF-7 cancer cells and effectively overcame drug resistance in MCF-7/ADR cells, significantly outperforming free DOX, which failed to be effective on resistant cells.
- Fluorescence imaging indicated that NPA@D accumulates mainly in tumor sites, reducing off-target effects and side effects, thereby showcasing potential for enhanced chemotherapy outcomes.