7 results match your criteria: "Shanxi Province Clinical Research Center for Dermatologic and Immunologic Diseases(Rheumatic Diseases)[Affiliation]"
Comments on "Baricitinib versus tocilizumab in mechanically ventilated patients with COVID-19: a nationwide cohort study".
Crit Care
December 2024
Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan, China.
Cell therapy in Sjögren's syndrome: opportunities and challenges.
Expert Rev Mol Med
October 2024
Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan, China.
Article Synopsis
- - Sjögren's syndrome (SS) is a chronic autoimmune condition characterized by dry mouth and eyes due to the destruction of salivary and lacrimal glands, with potential systemic issues like pneumonia and nephritis.
- - Current treatments mainly involve medications that manage inflammation but don't repair tissue, highlighting the need for innovative approaches like cell therapy.
- - Cell therapy, which includes stem and immune cell therapy, shows promise in reducing inflammation and aiding tissue repair for SS, yet challenges remain in preparation and logistics of these therapies.
Induced pluripotent stem cell-derived mesenchymal stem cells: whether they can become new stars of cell therapy.
Stem Cell Res Ther
October 2024
Shanxi Bethune Hospital, Tongji Shanxi Hospital, Third Hospital of Shanxi Medical University, Shanxi Academy of Medical Sciences, Taiyuan, 030032, China.
Stem cell therapy constitutes a pivotal subject in contemporary discourse, with donor stem cells having been employed in research and clinical treatments for several decades. Primary cell transplantation encompasses diverse stem cell types, including ectomesenchymal stem cells, hematopoietic stem cells, and various stem cell derivatives such as vesicles and extracellular vesicles. Nevertheless, the emergence of cell engineering techniques has heralded a new epoch in stem cell therapy, markedly broadening their therapeutic potential.
View Article and Find Full Text PDFIncreased m6A RNA methylation and METTL3 expression may contribute to the synovitis progression of rheumatoid arthritis.
Exp Cell Res
October 2024
Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan, China; Shanxi Province Clinical Research Center for Dermatologic and Immunologic Diseases (Rheumatic diseases), Taiyuan, China. Electronic address:
Article Synopsis
- Rheumatoid arthritis (RA) is an autoimmune disease marked by abnormal growth of synovial fibroblasts and joint damage, with m6A methylation emerging as an important modulator in its development.
- In this study, researchers examined the levels of m6A methylation and specific enzymes in RA synovial tissues, discovering that elevated METTL3 enhances RA-FLS growth and inflammation-related factors.
- Findings suggest that targeting METTL3 could reduce abnormal proliferation and promote apoptosis in RA-FLSs, indicating potential therapeutic avenues for RA treatment.
Observation of polarity changes in Sjogren's syndrome mice using a targeting lysosomes and ratiometric fluorescent probe.
Talanta
December 2024
Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, Shanxi Province Clinical Theranostics Technology Innovation Center for Immunologic and Rheumatic Diseases, Shanxi Province Clinical Research Center for Dermatologic and Immunologic Diseases(Rheumatic Diseases), Taiyuan, 030032, China. Electronic address:
Utilizing non-invasive, real-time dynamic imaging and high-resolution detection tools to track polarity changes in Sjögren's syndrome (SS) contributes to a better understanding of the disease progression. Herein, a ratiometric polarity-sensitive fluorescent probe (DIM) was designed and synthesized, DIM consisted of dicyanoisophorone as the fluorophore and morpholine moiety as lysosome targeting. DIM showed a ratiometric response to polarity and high selectivity (unaffected by viscosity, pH, ROS, RNS, etc.
View Article and Find Full Text PDFLong-term tracking of lysosomal dynamics with highly stable fluorescent probe.
Talanta
December 2024
Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, Shanxi Province Clinical Theranostics Technology Innovation Center for Immunologic and Rheumatic Diseases, Shanxi Province Clinical Research Center for Dermatologic and Immunologic Diseases（Rheumatic diseases), Taiyuan, 030032, China.
Monitoring lysosomal dynamics in real-time, especially in vivo, poses significant challenges due to the complex and dynamic nature of cellular environments. It is extremely important to construct fluorescent probes with high stability for imaging lysosomes to minimize interference from other cellular components, in order to ensure prolonged imaging. A fluorescent probe (PDB) has been proposed for targeting lysosomes, which was less affected to changes in the cellular microenvironment (such as pH, viscosity and polarity).
View Article and Find Full Text PDFApplication of omics in Sjögren's syndrome.
Inflamm Res
December 2023
Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan, 030032, China.
Objective: The pathogenesis, diagnosis, and treatment of Sjögren's syndrome (SS) face many challenges, and there is an urgent need to develop new technologies to improve our understanding of SS.
Methods: By searching the literature published domestically and internationally in the past 20 years, this artical reviewed the research of various omics techniques in SS.
Results: Omics technology provided valuable insights into the pathogenesis, early diagnosis, condition and efficacy evaluation of SS.