Preparation and characterization of Ru-TiO/PC/FeO composite catalyst with enhanced photocatalytic performance and magnetic recoverability under simulated solar light.

This research focuses on the development of a novel Ru-doped TiO/grapefruit peel biochar/FeO (Ru-TiO/PC/FeO) composite catalyst, which exhibits exceptional photocatalytic efficacy under simulated solar light irradiation. The catalyst is highly effective in the degradation of rhodamine B (RhB), methylene blue (MB), methyl orange (MO), as well as actual industrial dye wastewater (IDW), and can be recovered magnetically for multiple reuse cycles. Significantly, the PCTRF-100 sample exhibited degradation efficiencies of 99.

Ni-catalyzed asymmetric decarboxylation for the construction of carbocycles with contiguous quaternary carbon stereocenters.

The first Ni-catalyzed asymmetric decarboxylative strategy for the construction of carbocycles with contiguous quaternary all-carbon stereocenters is reported. The key to the success of these reactions is the utilization of rationally designed allenylic methylene cyclic carbonates as substrates with Ni catalysis. The floppy allenylic group exerts unique electronic properties on the carbonate, which allows further asymmetric nucleophilic annulations with alkenes.

Decisive reversal of lethal coronavirus disease 2019 in senescent hamster by synchronic antiviral and immunoregulatory intervention.

The poor prognosis observed in elderly individuals infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remains a serious clinical burden and the underlying mechanism is unclear, which necessities detailed investigation of disease characteristics and research for efficient countermeasures. To simulate lethal coronavirus disease 2019 (COVID-19) in senescent human patients, 80-week-old male hamsters are intranasally inoculated with different doses of SARS-CoV-2 Omicron BA.5 variant.

Photosensitizing metal covalent organic framework with fast charge transfer dynamics for efficient CO photoreduction.

Designing artificial photocatalysts for CO reduction is challenging, mainly due to the intrinsic difficulty of making multiple functional units cooperate efficiently. Herein, three-dimensional metal covalent organic frameworks (3D MCOFs) were employed as an innovative platform to integrate a strong Ru(ii) light-harvesting unit, an active Re(i) catalytic center, and an efficient charge separation configuration for photocatalysis. The photosensitive moiety was precisely stabilized into the covalent skeleton by using a rational-designed Ru(ii) complex as one of the building units, while the Re(i) center was linked a shared bridging ligand with an Ru(ii) center, opening an effective pathway for their electronic interaction.

Efficient Malaria Parasite Detection From Diverse Images of Thick Blood Smears for Cross-Regional Model Accuracy.

: The purpose of this work is to improve malaria diagnosis efficiency by integrating smartphones with microscopes. This integration involves image acquisition and algorithmic detection of malaria parasites in various thick blood smear (TBS) datasets sourced from different global regions, including low-quality images from Sub-Saharan Africa. This approach combines image segmentation and a convolutional neural network (CNN) to distinguish between white blood cells, artifacts, and malaria parasites.

Photochemical reduction of CO into CO coupling with triethanolamine decomposition.

In this work, the impacts of triethanolamine (TEOA) on the performance of photochemical CO reduction were investigated in a simple homogeneous system. We demonstrates that CO can be converted into CO coupling with the decomposition of triethanolamine in TEOA aqueous solution without other additives under light irradiation. About 7.

Visible-light-induced [3+2] cycloadditions of donor/donor diazo intermediates with alkenes to achieve (spiro)-pyrazolines and pyrazoles.

To date, [3 + 2] cycloadditions of diazo esters with alkynes or alkenes have been a robust tool to generate pyrazoles and pyrazolines. However, methods capable of generating donor/donor diazo species from readily available -tosylhydrazones to furnish [3 + 2] cycloadditions, remain elusive. Herein, we describe the first visible-light-induced [3 + 2] cycloadditions of donor/donor diazo precursors with alkenes to afford pyrazoles and novel (spiro)pyrazolines bearing a quaternary center.

Electrochemically-promoted synthesis of benzo[]thiophene-1,1-dioxides strained quaternary spirocyclization.

We report an approach for the synthesis of benzothiophene motifs under electrochemical conditions by the reaction of sulfonhydrazides with internal alkynes. Upon the formation of a quaternary spirocyclization intermediate by the selective -addition instead of an -attack, the S-migration process was rationalized to lead to the products. Computational studies revealed the selectivity and the compatibility of drug molecules showcased the potential application of the protocols.

: A serialized data object for visualization of a phylogenetic tree and annotation data.

While phylogenetic trees and associated data have been getting easier to generate, it has been difficult to reuse, combine, and synthesize the information they provided, because published trees are often only available as image files and associated data are often stored in incompatible formats. To increase the reproducibility and reusability of phylogenetic data, the object was designed for storing phylogenetic tree and associated data, as well as visualization directives. The object itself is a graphic object and can be rendered as a static image.

Sequence comparison of the mitochondrial genomes of five brackish water species of the family Neritidae: Phylogenetic implications and divergence time estimation.

Neritids are ancient gastropod species which can live in marine, brackish water, and freshwater environments. In this study, we sequenced and annotated the mitochondrial genomes of five brackish water neritids (i.e.

Practical asymmetric amine nucleophilic approach for the modular construction of protected α-quaternary amino acids.

We report the first amine nucleophilic approach for the modular construction of enantioenriched protected α-quaternary amino acids. The key to success is the use of an alcohol solvent, which makes a rationally designed COOMe-bonded Cu-allenylidene electrophilic intermediate stable enough to couple with amine nucleophiles before its decomposition. The reaction features wide functional group tolerance with high enantioselectivity, typically >90% ee, and is amenable to the modification of commercially available bioactive molecules.

Mesoporous PdBi nanocages for enhanced electrocatalytic performances by all-direction accessibility and steric site activation.

An effective yet simple approach was developed to synthesize mesoporous PdBi nanocages for electrochemical applications. This technique relies on the subtle utilization of the hydrolysis of a metal salt to generate precipitate cores as templates for navigating the growth of mesoporous shells with the assistance of polymeric micelles. The mesoporous PdBi nanocages are then obtained by excavating vulnerable cores and regulating the crystals of mesoporous metallic skeletons.

Hypervalent iodine promoted the synthesis of cycloheptatrienes and cyclopropanes.

A new strategy is reported for intramolecular Buchner-type reactions using PIDA as a promotor. Traditionally, the Buchner reaction is achieved Rh-carbenoids derived from Rh catalysts with diazo compounds. Herein, the first metal-free Buchner-type reaction to construct highly strained cycloheptatriene- and cyclopropane-fused lactams is presented.

Arsenic trioxide targets Hsp60, triggering degradation of p53 and survivin.

The mechanisms of action of arsenic trioxide (ATO), a clinically used drug for the treatment of acute promyelocytic leukemia (APL), have been actively studied mainly through characterization of individual putative protein targets. There appear to be no studies at a system level. Herein, we integrate metalloproteomics through a newly developed organoarsenic probe, As-AC (CHAsNOS) with quantitative proteomics, allowing 37 arsenic binding and 250 arsenic regulated proteins to be identified in NB4, a human APL cell line.

Pressure-induced phosphorescence enhancement and piezochromism of a carbazole-based cyclic trinuclear Cu(i) complex.

Interest in piezochromic luminescence has increased in recent decades, even though it is mostly limited to pure organic compounds and fluorescence. In this work, a CuPz (, Pz: pyrazolate) cyclic trinuclear complex (CTC) with two different crystalline polymorphs, namely and , was synthesized. The CTC consists of two functional moieties: carbazole () chromophore and units.

Patient-derived organoids of bladder cancer recapitulate antigen expression profiles and serve as a personal evaluation model for CAR-T cells .

Objectives: Recent advances in patient-derived cancer organoids have opened a new avenue for personalised medicine. We aimed to establish an technological platform to evaluate chimeric antigen receptor (CAR)-T cell-mediated cytotoxicity against bladder cancer.

Methods: Patient-derived bladder cancer organoids (BCOs) were derived using classic medium containing R-spondin 1 and noggin.

Tuning adlayer-substrate interactions of graphene/h-BN heterostructures on Cu(111)-Ni and Ni(111)-Cu surface alloys.

The evolution of the interface and interaction of h-BN and graphene/h-BN (Gr/h-BN) on Cu(111)-Ni and Ni(111)-Cu surface alloys the Ni/Cu atomic percentage on the alloy surface were comparatively studied by the DFT-D2 method, including the critical long-range van der Waals forces. Our results showed that the interaction strength and interface distance of Gr/h-BN/metal can be distinctly tuned by regulating the chemical composition of the surface alloy at the interface. The initially weak interaction of h-BN/Cu(111)-Ni increased linearly with increasing Ni atomic percentage, and the interface distances decreased from ∼3.

An integrated feature frame work for automated segmentation of COVID-19 infection from lung CT images.

The novel coronavirus disease (SARS-CoV-2 or COVID-19) is spreading across the world and is affecting public health and the world economy. Artificial Intelligence (AI) can play a key role in enhancing COVID-19 detection. However, lung infection by COVID-19 is not quantifiable due to a lack of studies and the difficulty involved in the collection of large datasets.

2-Bromoanthraquinone as a highly efficient photocatalyst for the oxidation of -aromatic alcohols: experimental and DFT study.

Anthraquinones are recognized as high efficiency photocatalysts which can perform various redox reactions in aqueous or organic phases. We have experimentally proven that 2-BrAQ can undergo hydrogen transfer with an alpha-aromatic alcohol under light conditions, thereby efficiently oxidizing the aromatic alcohol to the corresponding product. The yield of 1-phenethanol to acetophenone can reach more than 96%.

Immobilizing a visible light-responsive photocatalyst on a recyclable polymeric composite for floating and suspended applications in water treatment.

A visible light responsive TiO/AgPO (10 : 1) nanocomposite was prepared and successfully immobilized (12 wt%) in a spherical polymeric matrix consisting of polysulfone and alginate (10 : 6). The resulted beads featured a sponge-like structure with interconnected macrovoids and micropores, and showed high adsorption and visible-light photocatalytic activity towards various wastewater pollutants, including the widely used dye - methylene blue ( = 0.0321 min), and two emerging pharmaceutical contaminants - diclofenac ( = 0.

Highly Transparent and Flexible Iontronic Pressure Sensors Based on an Opaque to Transparent Transition.

Human-computer interfaces, smart glasses, touch screens, and some electronic skins require highly transparent and flexible pressure-sensing elements. Flexible pressure sensors often apply a microstructured or porous active material to improve their sensitivity and response speed. However, the microstructures or small pores will result in high haze and low transparency of the device, and thus it is challenging to balance the sensitivity and transparency simultaneously in flexible pressure sensors or electronic skins.

Dietary riboflavin deficiency promotes N-nitrosomethylbenzylamine-induced esophageal tumorigenesis in rats by inducing chronic inflammation.

Epidemiological studies in high-incidence areas of esophageal cancer in China suggest that environmental carcinogen N-nitrosomethylbenzylamine (NMBA) and riboflavin (RBF) deficiency may be the main risk factors for esophageal cancer. However, it is not clear that the combination induces cancer. Here, experiment (Exp) 1 evaluated the effects of NMBA and RBF deficiency individually or in combination on esophageal tumorigenesis.

Graphitic Carbon Nitride with Dopant Induced Charge Localization for Enhanced Photoreduction of CO to CH.

The photoreduction of CO to hydrocarbon products has attracted much attention because it provides an avenue to directly synthesize value-added carbon-based fuels and feedstocks using solar energy. Among various photocatalysts, graphitic carbon nitride (g-CN) has emerged as an attractive metal-free visible-light photocatalyst due to its advantages of earth-abundance, nontoxicity, and stability. Unfortunately, its photocatalytic efficiency is seriously limited by charge carriers' ready recombination and their low reaction dynamics.

Multiple biomarkers and arrhythmia outcome following catheter ablation of atrial fibrillation: The Guangzhou Atrial Fibrillation Project.

Background: Biomarkers have been related to the arrhythmia recurrence following catheter ablation (CA) of atrial fibrillation (AF). We hypothesized that concurrent measurement of several biomarkers would additively improve their predictive value.

Methods: One thousand four hundred and ten consecutive AF patients (68% male; 57.