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Diagnostic value of platelet indices and bone marrow megakaryocytic parameters in immune thrombocytopenic purpura.

Blood Coagul Fibrinolysis

January 2017

aLaboratory Medicine Center, Nangfang Hospital, Southern Medical University, Guangzhou bDepartment of Cell Biology and Genetics, Shantou University Medical College cShantou University Medical College, Shantou, Guangdong, China.

Article Synopsis
  • Platelet indices, such as mean platelet volume (MPV) and plateletcrit (PCT), may indicate megakaryopoietic activity in patients with immune thrombocytopenic purpura (ITP), but their diagnostic accuracy still needs further research.
  • In comparison with myelodysplasia and control groups, patients with ITP showed higher MPV, lower PCT, and a unique platelet distribution width pattern, along with increased megakaryocytes.
  • Sensitivity and specificity tests revealed that MPV and PCT can be effective markers for diagnosing ITP, especially when combined in parallel or series tests, suggesting their potential utility in clinical settings.
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