8,046 results match your criteria: "Shantou University Medical College; xlzhou@stu.edu.cn.[Affiliation]"
Genetically predicted Caspase 8 levels mediates the causal association between CD4+ T cell and breast cancer.
Front Immunol
October 2024
Department of Radiology, The First Affiliated Hospital of Shantou University Medical College, Shantou, China.
Background: Breast cancer (BC) remains a significant contributor to female mortality globally, with inflammation and the immune system implicated in its pathogenesis. To elucidate potential causal relationships, we evaluated the relationship among 731 immune cell phenotypes and BC be at risk by using Mendelian randomization (MR), while also exploring inflammatory proteins as mediators in this association.
Methods: We obtained immune cell genome-wide association study (GWAS) summary data and 91 inflammatory factors from the GWAS Catalog.
HPV16 E6-induced M2 macrophage polarization in the cervical microenvironment via exosomal miR-204-5p.
Sci Rep
October 2024
Genetics Laboratory, Longgang District Maternity & Child Healthcare Hospital of Shenzhen City (Longgang Maternity and Child Institute of Shantou University Medical College), Shenzhen, 518116, China.
Article Synopsis
- Persistent HPV infections contribute to cervical cancer progression by influencing local immune responses, particularly the infiltration of M2 macrophages.
- The study reveals that exosomes from HPV E6+ cervical cancer cells play a key role in polarizing macrophages to the M2 type, primarily through the action of miR-204-5p, which inhibits a protein called JAK2.
- This research highlights the potential of exosomal miR-204-5p as both a biomarker for assessing cervical lesion severity and a target for future therapeutic strategies.
Effects of multiple fluid intake on Urolithiasis by mendelian randomization study.
Sci Rep
October 2024
Department of Neurology, Peking University Shenzhen Hospital, Peking University, Lianhua Road 1120, Futian District, 518036, Shenzhen, Guangdong Province, China.
Article Synopsis
- *Using genetic data from over 400,000 participants, the study found that coffee and tea consumption may reduce the risk of developing kidney stones, while milk and alcohol increase that risk.
- *These results underscore the potential of dietary choices in preventing urolithiasis, suggesting that increasing tea intake and moderating milk and alcohol consumption could be beneficial.
Engineering Bacterial Chitinases for Industrial Application: From Protein Engineering to Bacterial Strains Mutation! A Comprehensive Review of Physical, Molecular, and Computational Approaches.
J Agric Food Chem
October 2024
School of Life Sciences, Jiangsu University, Zhenjiang, Jiangsu 212000, P. R. China.
Bacterial chitinases are integral in breaking down chitin, the natural polymer in crustacean and insect exoskeletons. Their increasing utilization across various sectors such as agriculture, waste management, biotechnology, food processing, and pharmaceutical industries highlights their significance as biocatalysts. The current review investigates various scientific strategies to maximize the efficiency and production of bacterial chitinases for industrial use.
View Article and Find Full Text PDFTRPM8 overexpression suppresses hepatocellular carcinoma progression and improves survival by modulating the RTP3/STAT3 pathway.
Cancer Med
October 2024
Department of Laboratory Medicine, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital; Shenzhen Key Laboratory of Medical Laboratory and Molecular Diagnostics; Guangzhou Medical University, Shenzhen, China.
Article Synopsis
- Hepatocellular carcinoma (HCC) is a severe liver cancer with high rates of illness and death, and the study investigates the role of the protein TRPM8 in HCC progression.
- Researchers analyzed TRPM8 levels in HCC tissues and conducted various laboratory tests to understand how TRPM8 affects cell growth and movement, and used a mouse model for in vivo experiments.
- The study found that lower TRPM8 levels in HCC tissues were linked to worse patient outcomes, suggesting TRPM8 helps to slow cancer cell growth and spread through a specific signaling pathway involving RTP3 and STAT3, with a compound called AD80 promoting TRPM8 expression and potential anti-tumor effects.
Study on the effects of intraoperative administration of dexmedetomidine on the prognosis and survival outcomes of patients with colorectal cancer.
Heliyon
October 2024
Shantou University Medical College, Shantou, 515041, Guangdong Province, China.
Article Synopsis
- The study investigates the effects of dexmedetomidine, used during colorectal cancer surgery, on patient survival rates and recurrence-free survival.
- It involved 76 patients, with a comparison between those who received dexmedetomidine and those who did not, showing significant improvements in survival for the dexmedetomidine group.
- The findings suggest that using dexmedetomidine in surgery could enhance long-term outcomes and reduce cancer recurrence for colorectal cancer patients.
Mitochondrial-related genes as prognostic and metastatic markers in breast cancer: insights from comprehensive analysis and clinical models.
Front Immunol
October 2024
Department of Breast Surgery, Cancer Hospital of Shantou University Medical College, Shantou, Guangdong, China.
Article Synopsis
- Breast cancer is a major health threat for women globally, with new research indicating that mitochondrial dysfunction may significantly contribute to its development and progression, though studies on mitochondrial-related genes (MRGs) and breast cancer prognosis are still limited.
- The study utilized TCGA database data to analyze MRGs and create a prognostic model through various statistical methods, including Cox and LASSO regression, and validated findings using additional datasets while conducting comprehensive analyses of tumor characteristics and responses to treatment.
- A prognostic model was developed using 9 specific MRGs, indicating that patients in the high-risk group faced poorer outcomes, further validated through ROC curves and a nomogram for risk assessment.
Case Report: Primary ciliary dyskinesia due to CCNO mutations: a Chinese pediatric case series and literature review.
Front Pediatr
September 2024
Department of Respiratory Diseases, Shenzhen Children's Hospital Affiliated to Shantou University Medical College, Shenzhen, China.
Article Synopsis
- Primary ciliary dyskinesia (PCD) is a hereditary condition that affects cilia, leading to issues with clearing mucus from the lungs, and this study focuses on PCD linked to mutations in the CCNO gene, involving three Chinese children.
- The cases include an 8-year-old boy diagnosed with respiratory issues akin to diffuse panbronchiolitis, his sister with similar symptoms requiring oxygen, and a 4-year-old girl with a history of pneumonia and recurrent infections, all confirmed to have PCD through genetic testing.
- Key clinical features of CCNO-PCD were identified, such as neonatal respiratory distress, chronic cough, and low nasal nitric oxide levels, indicating that while cilia may appear normal, they
Weighing the future: strategic measures against rising childhood obesity.
Pediatr Res
October 2024
Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 100021, Beijing, China.
Overexpression of TPD52L2 in HNSCC: prognostic significance and correlation with immune infiltrates.
BMC Oral Health
October 2024
The Department of Head and Neck Surgery, Cancer Hospital of Shantou University Medical College, Shantou, Guangdong, 515041, China.
Background: Evidence has been presented that the tumor protein D52 (TPD52) family plays a critical role in tumor development and progression. As a member of the TPD52 family, the changes in TPD52L2 gene status are instrumental in kinds of cancer development. However, its effects on patient prognosis and immune infiltration in Head and Neck Squamous Carcinoma (HNSCC) are still poorly understood.
View Article and Find Full Text PDFThe nodule-pleura relationship affects pneumothorax in CT-guided percutaneous transthoracic needle biopsy: avoiding to cross pleural tail sign may reduce the incidence of pneumothorax.
BMC Pulm Med
October 2024
Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Radiology, Peking University Cancer Hospital & Institute, No. 52, Fucheng Road, Hai Dian District, Beijing, 100142, China.
Article Synopsis
- - The study analyzed how different types of nodule-pleural relationships (like those with pleural tail signs) affect the risk of pneumothorax during CT-guided biopsies in lung nodules.
- - Results showed that nodules in contact with the pleura had a lower risk of pneumothorax compared to those with pleural tail signs or being pleural unrelated, highlighting the importance of nodule positioning.
- - Key factors increasing the risk of pneumothorax included crossing pleural tail signs, longer biopsy time, deeper needle insertion, and nodules located in the middle or lower lobes.
Machine learning based intratumor heterogeneity signature for predicting prognosis and immunotherapy benefit in stomach adenocarcinoma.
Sci Rep
October 2024
Department of Internal Medicine, Cancer Hospital of Shantou University Medical College, Shantou, 515000, China.
Article Synopsis
- Stomach adenocarcinoma (STAD) is a serious type of stomach cancer that can change a lot, making it hard to treat and often spreading to other parts of the body.
- Researchers created a special score called the Intratumor Heterogeneity-related Signature (IRS) to predict how well patients with STAD might respond to treatments like immunotherapy.
- They found that a low IRS score means better chances for patients, and experiments showed that a gene called AKR1B1 is important because when it's turned down, cancer cells grow and spread less.
Association of the newly proposed dietary index for gut microbiota and depression: the mediation effect of phenotypic age and body mass index.
Eur Arch Psychiatry Clin Neurosci
October 2024
Shantou University Medical College, Shantou, Guangdong, China.
Article Synopsis
- The study explored the relationship between gut microbiota diversity, measured by the Dietary Index for Gut Microbiota (DI-GM), and depression.
- Higher scores on the DI-GM and beneficial gut microbiota were linked to a lower prevalence of depression and lower scores on the PHQ-9 depression assessment.
- Phenotypic age and body mass index (BMI) were found to significantly mediate the association between gut microbiota diversity and depression, suggesting these factors play a role in this relationship.
Associations of HALP score with serum prostate-specific antigen and mortality in middle-aged and elderly individuals without prostate cancer.
Front Oncol
September 2024
Department of Urology, The Affiliated Shunde Hospital of Jinan University (The Second People's Hospital of Shunde), Foshan, China.
Background: The association between the Hemoglobin, Albumin, Lymphocyte, and Platelet (HALP) score and serum prostate-specific antigen (PSA) and all-cause mortality remains underexplored. We aimed to investigate the relationship between HALP score and these outcomes among middle-aged and elderly individuals without prostate cancer (PCa).
Methods: This cross-sectional study included participants aged 40 years and older from National Health and Nutrition Examination Survey (NHANES) 2001-2010.
Therapeutic effects of paeonol on non‑small cell lung cancer cells via regulation of the MAPK pathway.
Oncol Lett
December 2024
Department of Thoracic Surgery, Yuebei People Hospital Affiliated to Medical College of Shantou University, Shaoguan, Guangdong 512000, P.R. China.
Article Synopsis
- The study explored how paeonol affects DNA repair, triggers cell death (apoptosis), and reduces cell survival in non-small cell lung cancer cells (H1299) using the MAPK pathway.
- Human bronchial epithelial cells (BEAS-2B) and H1299 cells were treated with varying concentrations of paeonol, and different assays were conducted to assess cell viability, apoptosis, and DNA damage.
- Results showed that higher doses of paeonol decreased cell viability and colony formation while increasing apoptosis and DNA damage, affecting key proteins involved in cell survival and the MAPK signaling pathway.
Exploring the gut microbiota landscape in cow milk protein allergy: Clinical insights and diagnostic implications in pediatric patients.
J Dairy Sci
January 2025
Department of Cell Biology and Genetics, Shantou University Medical College, Shantou 515041, China. Electronic address:
Cow milk protein allergy (CMPA) is a significant health concern characterized by adverse immune reactions to cow milk proteins. Biomarkers for the accurate diagnosis and prognosis of CMPA are lacking. This study analyzed the clinical features of CMPA, and 16S RNA sequencing was used to investigate potential biomarkers through fecal microbiota profiling.
View Article and Find Full Text PDFThe molecular design of novel phospholipid-inspired ionic liquid transdermal penetration enhancers: Innovative insights on the action mode and mechanism.
Int J Pharm
December 2024
Department of Pharmacy, Shantou University Medical College, Shantou 515041, China; Department of Pharmacy, Department of Dermatology, The First Affiliated Hospital of Shantou University Medical College, Shantou 515041, China. Electronic address:
Article Synopsis
- Ionic liquid transdermal penetration enhancers (IL@TPEs) show promise in improving drug delivery through the skin, but there was a lack of scientific guidelines for designing effective ones.
- Researchers created novel biomimetic phospholipid-inspired IL@TPEs (PIL@TPEs) and discovered their effectiveness relies on the chemical properties of both drugs and cations involved in the formulation.
- The study revealed that PIL@TPEs behave differently than traditional enhancers, demonstrating strong interactions with drugs and skin, and ensuring safety through various biological tests.
The impact of the COVID-19 pandemic on RSV outbreaks in children: A multicenter study from China.
Respir Med
November 2024
Department of Respiratory Medicine, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Rare Diseases in Infection and Immunity, Chongqing, 400014, China. Electronic address:
Article Synopsis
- The study investigates how RSV (Respiratory Syncytial Virus) prevalence patterns in China were affected during the COVID-19 pandemic from 2019 to 2022.
- It analyzed data from over 872,000 children and found that while RSV detection rates rose during the pandemic, especially in children under 5, a notable decline occurred in 2022.
- The research concludes that the pandemic disrupted typical RSV seasonal patterns, resulting in increased year-long outbreaks and a lack of clear seasonal trends post-April 2022.
Intra-arterial chemotherapy combined with BCG immunotherapy is more effective than intra-arterial chemotherapy plus intravesical chemotherapy or standard BCG immunotherapy in preventing the recurrence and progression of high-risk non-muscle-invasive bladder cancer.
Urol Oncol
December 2024
Department of Urology, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong Province, P.R.China. Electronic address:
Article Synopsis
- Up to 45% of high-risk non-muscle-invasive bladder cancer (NMIBC) patients may not benefit from traditional intravesical treatment, leading researchers to explore the feasibility and safety of combining it with intra-arterial chemotherapy (IAC).
- A study collected data from 143 patients diagnosed with high-risk NMIBC, dividing them into three treatment groups: one receiving only Bacillus Calmette-Guerin (BCG), another receiving BCG plus IAC, and a third receiving intravesical chemotherapy (IVC) plus IAC, with both IAC groups receiving additional courses of IAC.
- Results showed that the BCG+IAC group had significantly better recurrence and progression-free survival compared to the
Practice Patterns and Challenges in Managing Inherited Retinal Diseases Across Asia-Pacific: A Survey from the APIED Network.
Asia Pac J Ophthalmol (Phila)
October 2024
Centre for Innovation & Precision Eye Health, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Department of Ophthalmology, National University Hospital, National University Health System, Singapore; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. Electronic address:
Article Synopsis
- The paper looks at how inherited retinal diseases (IRD) are diagnosed and treated in the Asia-Pacific region.
- They surveyed 36 centers about their practices, including how they collect patient information and provide help for low vision.
- The results showed there are important gaps, like many centers not having a database for patients, not enough genetic counselors, and a need for better support for low-vision rehabilitation.
Glutamine Attenuates Inflammation and Stimulates Amniotic Cell Proliferation in Premature Rupture of Membranes-related in vitro Models.
Reprod Sci
October 2024
Department of Obstetrics, Longgang Maternity and Child Institute of Shantou University Medical College, Shenzhen, 518172, China.
Premature rupture of membranes (PROM), with a prevalence of 15.3% in China, frequently results in adverse pregnancy outcomes. In this study, we aimed to identify amino acid metabolites that were differentially expressed in PROM versus healthy controls (HC) using targeted metabolomics and further explored their mechanisms of action with in vitro models.
View Article and Find Full Text PDFBiomechanical Study of Atlanto-occipital Instability in Type II Basilar Invagination: A Finite Element Analysis.
Neurospine
September 2024
Department of Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Objective: Recent studies indicate that 3 morphological types of atlanto-occipital joint (AOJ) exist in the craniovertebral junction and are associated with type II basilar invagination (BI) and atlanto-occipital instability. However, the actual biomechanical effects remain unclear. This study aims to investigate biomechanical differences among AOJ types I, II, and III, and provide further evidence of atlanto-occipital instability in type II BI.
View Article and Find Full Text PDFTargeting osteoblastic 11β-HSD1 to combat high-fat diet-induced bone loss and obesity.
Nat Commun
October 2024
Law Sau Fai Institute for Advancing Translational Medicine in Bone and Joint Diseases, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, China.
Article Synopsis
- Excessive glucocorticoid (GC) action is linked to metabolic disorders, and recent studies show that disrupting GC signaling in bones can prevent bone loss and improve metabolism in obese mice on a high-fat diet (HFD).
- High levels of the enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) in osteoblasts are associated with obesity and bone loss in these mice, and knocking out this enzyme specifically in osteoblasts protects against these issues.
- Inhibiting osteoblastic 11β-HSD1 with a targeted drug promotes bone growth, improves glucose usage, and helps reduce obesity in HFD-fed male mice, highlighting its key role in these
Applications of Pythium- and Phytophthora-produced volatiles in plant disease control.
Appl Microbiol Biotechnol
October 2024
Key Lab of Food Quality and Safety of Jiangsu Province-State Key Laboratory Breeding Base, Institute of Plant Protection, Jiangsu Academy of Agricultural Sciences, 50 Zhongling St, Nanjing, 210014, China.
Article Synopsis
- Some tiny chemicals called VOCs are made by certain plant pathogens, like Pythium and Phytophthora, which can help in finding and controlling plant diseases.
- Scientists have studied these VOCs to see how they work and how they can affect other microorganisms and plants.
- Future research aims to learn more about how these VOCs are produced and to test different kinds of pathogens to improve plant disease detection and control.
Risk prediction modelling in idiopathic inflammatory myositis-associated interstitial lung disease based on seven factors including serum KL-6 and lung ultrasound B-lines.
Clin Exp Rheumatol
October 2024
Department of Rheumatology and Immunology, Shantou Central Hospital, Shantou, China.
Article Synopsis
- The study aimed to create an easy-to-use nomogram for predicting interstitial lung disease (ILD) in patients with idiopathic inflammatory myositis (IIM) based on a large retrospective analysis of 205 patients from Shantou Central Hospital.
- Using LASSO regression, researchers identified four risk factors (age, respiratory symptoms, MDA-5 antibodies, and anti-ARS antibodies) and found that including KL-6 levels and LUS B-lines significantly improved the model's predictive accuracy.
- The final model showed strong predictive performance with an ROC AUC of up to 0.951, and a web version was created to enhance accessibility for clinicians.