Inhibition of human thrombin by the constituents of licorice: inhibition kinetics and mechanistic insights through and studies.

Thrombin inhibition therapy is a practical strategy to reduce thrombotic and cardiovascular risks blocking the formation of blood clots. This study aimed to identify naturally occurring thrombin inhibitors from licorice (one of the most popular edible herbs), as well as to investigate their inhibitory mechanisms. Among all tested licorice constituents, licochalcone A was found as the most efficacious agent against human thrombin (IC = 7.