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Solubility determination, dissolution properties and solid transformation of resmetirom (form A) in heptane and seven alcohols.
RSC Adv
July 2023
College of Chemistry and Chemical Engineering, Shanghai University of Engineering Science Shanghai 201620 China +86 21 67791214.
Article Synopsis
- - The solubility of resmetirom (form A) was measured in various solvents, and it was found that the modified Apelblat equation and Jouyban-Acree-van't Hoff model provided high accuracy in predicting solubility, with an average relative deviation under 0.5%.
- - Transformational dynamics between form A and its ethanol solvate were assessed, revealing a significant impact of hydrogen bonding and other factors like solvent polarity and molecular size on solubility.
- - A new high-precision quantitative method was developed using partial least squares regression (PLSR) to analyze the transformation process from form A to solvates, showing that temperature affects the rates of transformation due to solubility differences.