CPRS: a clinical protocol recommendation system based on LLMs.

Background: As fundamental documents in clinical trials, clinical trial protocols are intended to ensure that trials are conducted according to the objectives set by researchers. The advent of large models with superior semantic performance compared to traditional models provides fresh perspectives for research recommendations in clinical trial protocols.

Method: A clinical trial protocol recommendation system based on Large Language Models (LLMs) is proposed in this paper, combining GPT-4 and knowledge graph to assist in clinical trial protocol recommendations.

All-Atom Perspective of the DENV-3 Methyltransferase Inhibition Mechanism.

The Dengue virus (DENV) is an enveloped, single-stranded RNA virus with several antigenically distinct serotypes (DENV-1 to DENV-5). Dengue fever, as a major public health threat transmitted by mosquitoes, affects millions of people worldwide (especially in tropical and subtropical regions). Toward drug developments of DENV, the nonstructural protein 5 methyltransferase (MTase) serves as an attractive target.

Sustainable Immunomodulatory via Macrophage P2Y12 Inhibition Mediated Bioactive Patche for Peritendinous Antiadhesion.

Persistent anti-inflammatory responses are critical for the prevention of peritendinous adhesion. Although modified anti-adhesion barriers have been studied extensively, the immune response induced by the implants and the unclear mechanism limits their application. In this research, the advantage of the multi-functionalities of CA (caffeic acid) is taken to synthesize biodegradable poly (ester urethane) urea elastomers with ester- and carbamate-bonded CA (PEUU-CA).

An evolutionary game study of traffic safety risk regulation considering public participation behavior.

With the development of transportation technology, the improvement of transportation efficiency also increases the complexity and diversity of traffic safety risks; the public's concern for traffic safety risks is increasing, and the traditional regulatory model is difficult to meet the improvement of the effectiveness of the safety regulation of the huge transportation network and the public's changing safety needs. In order to enhance the effectiveness of safety regulation, a game model of safety risk regulation among the public, transport enterprises, and regulators is constructed to simulate the effects of different traffic risks, penalty levels, and exposure rates on the behavior of transport enterprises and regulators. The results of the study show that: traffic risk has a positive facilitating effect on the participation of transport enterprises and the public in the regulation of safety risks, which will accelerate the process of stabilization of their strategies; transport enterprises have a high sensitivity to changes in the level of punishment, and only when the level of punishment exceeds a certain threshold will they be able to promote the choice of complying with the transport; and a higher exposure will lead to a greater tendency for transport enterprises to choose complying with the transport.

Kinase-Bench: Comprehensive Benchmarking Tools and Guidance for Achieving Selectivity in Kinase Drug Discovery.

Developing selective kinase inhibitors remains a formidable challenge in drug discovery because of the highly conserved structural information on adenosine triphosphate (ATP) binding sites across the kinase family. Tailoring docking protocols to identify promising kinase inhibitor candidates for optimization has long been a substantial obstacle to drug discovery. Therefore, we introduced "Kinase-Bench," a pioneering benchmark suite designed for an advanced virtual screen, to improve the selectivity and efficacy of kinase inhibitors.

A short-time, low-dosage chemicals dyeing of polyester/cotton blended fabric with benzothiazole dyes in water-less, salt-free dyeing system.

Non-aqueous media dyeing technology has highly innovative as it reduces pollution without increasing cost in polyester/cotton blended fabric dyeing. However, disperse dyes can stain in cotton component of the polyester/cotton blended fabric during dyeing process, resulting poor quality of dyed products. In this study, a groundbreaking comprehensive investigation was conducted on the dyeing behavior of C.

Corrigendum: Analysis of the structure and trend prediction of China's total health expenditure.

[This corrects the article DOI: 10.3389/fpubh.2024.

Structural analysis and intelligent classification of clinical trial eligibility criteria based on deep learning and medical text mining.

Objective: To enhance the efficiency, quality, and innovation capability of clinical trials, this paper introduces a novel model called CTEC-AC (Clinical Trial Eligibility Criteria Automatic Classification), aimed at structuring clinical trial eligibility criteria into computationally explainable classifications.

Methods: We obtained detailed information on the latest 2,500 clinical trials from ClinicalTrials.gov, generating over 20,000 eligibility criteria data entries.

DV-DETR: Improved UAV Aerial Small Target Detection Algorithm Based on RT-DETR.

For drone-based detection tasks, accurately identifying small-scale targets like people, bicycles, and pedestrians remains a key challenge. In this paper, we propose DV-DETR, an improved detection model based on the Real-Time Detection Transformer (RT-DETR), specifically optimized for small target detection in high-density scenes. To achieve this, we introduce three main enhancements: (1) ResNet18 as the backbone network to improve feature extraction and reduce model complexity; (2) the integration of recalibration attention units and deformable attention mechanisms in the neck network to enhance multi-scale feature fusion and improve localization accuracy; and (3) the use of the Focaler-IoU loss function to better handle the imbalanced distribution of target scales and focus on challenging samples.

Commodity Wi-Fi-Based Wireless Sensing Advancements over the Past Five Years.

With the compelling popularity of integrated sensing and communication (ISAC), Wi-Fi sensing has drawn increasing attention in recent years. Starting from 2010, Wi-Fi channel state information (CSI)-based wireless sensing has enabled various exciting applications such as indoor localization, target imaging, activity recognition, and vital sign monitoring. In this paper, we retrospect the latest achievements of Wi-Fi sensing using commodity-off-the-shelf (COTS) devices from the past 5 years in detail.

Recent progress in carbon nanomaterials for highly flexible fibrous aqueous zinc-ion batteries.

Fibrous zinc-ion batteries (FZIBs) are ideal wearable energy storage devices with unparalleled utility in the next generation of flexible electronics. However, the conventional electrode materials still present challenges to achieve both good electrochemical performance and mechanical deformability. This hinders their large-scale production and commercial application.

Human fall simulation testing method: where we are.

Falls pose a significant threat to human health and safety. Accurately assessing the protective effectiveness of fall protection products can significantly reduce the occurrence of fall accidents. This paper systematically reviews the types and risk factors of human falls and then discusses the current research status and future prospects of various test methods for human fall protection.

Natural helical carboxymethyl cellulose fibers-based actuator for smart controller applications.

Water-responsive polymers have received great attention in the field of smart actuators due to their mechanical response to humidity without energy consumption. Natural polymers-based actuators are competitive because of their green, sustainable, and biocompatible characteristics. In this paper, we report a natural twisting carboxymethyl cellulose (CMC) fiber-based actuator (TCFA) with remarkable performance under water and moist stimulation.

Incorporation of polyvinyl alcohol in bacterial cellulose/polypyrrole flexible conductive films to enhance the mechanical and conductive performance.

The integration of polypyrrole (PPy) into bacterial cellulose (BC) has provided significant conductivity and cost benefits. However, this combination has led to a reduction in mechanical properties, particularly in terms of elongation at break and tensile strength. This study investigated the enhancement of BC/PPy composite films by incorporating polyvinyl alcohol (PVA).

A within-subject voxel-wise constant-block partial least squares correlation method to explore MRI-based brain structure-function relationship.

The brain structure-function relationship is crucial to how the human brain works under normal or diseased conditions. Exploring such a relationship is challenging when using the 3-dimensional magnetic resonance imaging (MRI) functional dataset which is temporal dynamic and the structural MRI which is static. Partial Least Squares Correlation (PLSC) is one of the classical methods for exploring the joint spatial and temporal relationship.

Bilayer Scaffolds Synergize Immunomodulation and Rejuvenation via Layer-Specific Release of CK2.1 and the "Exercise Hormone" Lac-Phe for Enhanced Osteochondral Regeneration.

Repairing osteochondral defects necessitates the intricate reestablishment of the microenvironment. The cartilage layer consists of a porous gelatin methacryloyl hydrogel (PGelMA) covalently crosslinked with the chondroinductive peptide CK2.1 via a "linker" acrylate-PEG-N-hydroxysuccinimide (AC-PEG-NHS).

Tubular nanofiber membranes combined with Z-scheme CuS@CoS heterojunction catalyst for high-efficient removal of polyvinyl alcohol from waste water with high COD.

Polyvinyl alcohol (PVA), a typical water-soluble polymer with huge global production, is becoming one of the most ubiquitous pollutants and indeed the villain of the piece contributing high chemical oxygen demand (COD) in wastewater. Membrane technology is an effective method for wastewater purification, in particular, with the combination of peroxymonosulfate (PMS)-assisted advanced oxidation or photocatalytic process, is capable of maintaining high water flux and anti-fouling. Herein, a ZIF-67 derived Z-scheme CuS@CoS heterojunction catalyst immobilized by poly (m-phenylene isophthalamide) (PMIA) tubular nanofiber membrane (CuS@CoS/PMIA-TNM) is designed using a polyester braided tube as interior reinforcement.

Super Astragalus polysaccharide in specific gut microbiota metabolism alleviates chronic unpredictable mild stress-induced cognitive deficits mice.

Chronic stress affects intestinal microbiota. Astragaloside IV (AS), called super Astragalus polysaccharide, is a monomer component of traditional herbs Astragalus membranaceus which belongs to medicinal food homology (MFH), exerts a neuroprotection effect, but the underlying mechanism has not yet been elucidated. Intestinal flora is also involved in the biotransformation of the active ingredients of MFH species, thus affecting their physiological and pharmacological properties.

Variations of chloride depletion and its impacts on ozone formation: Case study of a coastal area in Shanghai.

Chlorine plays a critical role in atmospheric chemistry. Marine chloride depletion, as a significant source of atmospheric chlorine, impacts coastal acid deposition, atmospheric oxidizing capacity, and global climate. Based on continuous monitoring data of PM water soluble ions, criteria pollutants, and meteorological data at Chongming Dongtan supersite from 2019 to 2022, variations in chloride depletion and related impact factors were analyzed.

Smart Cancer-Targeting and Super-Sensitive Sensing of Eu/Tb-Induced Hyaluronan Characteristic Nano-Micelles with Effective Drug Loading and Release.

To avoid the critical problems of effective drugs not being carried to their targeted cancers and their quantity and location not being sensed in situ, this work presents a completely new innovative strategy to achieve both smart cancer targeting (SCT) and super-sensitive sensing (SSS), where one drug carrier works for effective drug loading and release. Herein, malignant melanoma treatment is used as an example of reliable detection and effective therapy. We report two characteristic dumbbell-like nano-micelles and spherical-like nano-micelles of hyaluronan induced by the Eu/Tb complexes for effective drug loading and release, respectively.