99 results match your criteria: "Shanghai University of Chinese Traditional Medicine[Affiliation]"

Polyphenols, known for their potent antioxidant and anti-inflammatory properties, have emerged as promising, natural, and safe complementary treatment options for metabolic-associated steatotic liver disease (MASLD). Among these, curcumin, resveratrol, and silymarin are the most extensively studied; however, their differential effects on MASLD outcomes remain inconclusive. This systematic review and meta-analysis of RCTs aimed to evaluate the efficacy of curcumin, resveratrol, and silymarin in patients with MASLD.

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Background: Lung cancer poses a significant global health challenge. Adaptive radiotherapy (ART) addresses uncertainties due to lung tumor dynamics. We aimed to investigate a comprehensively and systematically validated offline ART regimen with high clinical feasibility for lung cancer.

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Tract-Specific White Matter Hyperintensities Disrupt Brain Networks and Associated With Cognitive Impairment in Mild Traumatic Brain Injury.

Hum Brain Mapp

December 2024

The Key Laboratory of Biomedical Information Engineering, Ministry of Education, Department of Biomedical Engineering, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, China.

Article Synopsis
  • Traumatic brain injury (TBI) leads to cerebrovascular issues and various neurodegenerative conditions, with this study focusing on mild TBI (mTBI) and its effects on cognitive function through imaging and assessments.
  • MRI data from 85 mTBI patients and 52 healthy controls showed that increased white matter hyperintensity (WMH) volumes, particularly in specific brain regions, correlate with disrupted brain dynamics and cognitive impairments.
  • Results indicated that each 1 mL increase in WMH volume linked to significant delays in cognitive processing, highlighting the role of small vessel lesions in affecting brain function post-mTBI.
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  • Recent research indicates that artificial intelligence (AI) is enhancing the efficiency of radiotherapy (RT) for tumor treatment, yet there was a lack of bibliometric studies on this relationship.* -
  • An analysis of 615 publications from 2003 to 2023 revealed significant contributions from the USA and China, with Maastricht University being the leading research center and "Frontiers in Oncology" being the predominant journal.* -
  • Key research trends identified include "autocontouring algorithm", "deep learning", and "machine learning", providing valuable insights for academics exploring the interplay between AI and RT.*
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  • Hepatocellular carcinoma (HCC) is a highly aggressive liver cancer with few effective treatments available.
  • Recent studies have shown that changes in bile acids (BAs) profiles may be linked to HCC incidence, influencing tumor cell behaviors like growth and migration, as well as interactions with gut microbiota and immune responses.
  • The review explores the dual roles of BAs in both promoting and suppressing tumors, discusses potential therapeutic strategies targeting specific BA species, and highlights new research directions in BA biology related to HCC.
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Research progress on anti-tumor mechanism of TAOK kinases.

Cell Signal

December 2024

School of Health Science and Engineering, University of Shanghai for Science and Technology, Yangpu, 200093 Shanghai, China; Collaborative Innovation Center for Biomedicine, Shanghai University of Medicine &Health Sciences, Pudong, 201318 Shanghai, China. Electronic address:

Thousand and one amino-acid protein kinases(TAOKs), as a key member of the mitogen-activated protein kinase (MAPK) cascade, has recently attracted widespread attention in the field of anti-cancer research. There are three members of this subfamily: TAOK1, TAOK2, and TAOK3. Studies have shown that members of the TAOK family participate in regulating cell proliferation, apoptosis, migration, and invasion through various pathways, thereby playing an important role in tumorigenesis and progression.

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Background: Non-alcoholic steatohepatitis (NASH), an escalating global health concern, is a primary factor behind cirrhosis, liver transplantation, and hepatocellular carcinoma. Effective treatments remain elusive. Danggui-Shaoyao-San (DGSY), a classic famous prescription employed in treating NASH, could hold promise, although its molecular underpinnings are still under investigation.

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Background: This study aims to assess the efficacy and safety of Endostar in the management of locally advanced cervical cancer.

Methods: This retrospective, 2-center study enrolled 41 patients with locally advanced cervical cancer between June 2017 and December 2020. The patients were subjected to a combination of Endostar and chemoradiotherapy until they experienced disease progression or an unacceptable level of toxicity.

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  • This study evaluates the combination of a PD-1 inhibitor with total neoadjuvant therapy (iTNT) in improving complete response rates in patients with proficient mismatch repair locally advanced rectal cancer.
  • A total of 130 patients were randomized into two groups receiving different treatment regimens, with a significant number achieving a complete response (CR) at a follow-up of 19 months.
  • The results showed that both treatment groups had improved CR rates compared to historical data, suggesting that the iTNT approach is promising and warrants further research.
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IL-1 receptor-associated kinase family proteins: An overview of their role in liver disease.

Eur J Pharmacol

September 2024

Institute of Liver Diseases, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China; Central Laboratory, ShuGuang Hospital Affiliated to Shanghai University of Chinese Traditional Medicine, Shanghai, 201203, China; Key Laboratory of Liver and Kidney Diseases, Shanghai University of Traditional Chinese Medicine, Ministry of Education, Shanghai, 201203, China. Electronic address:

The interleukin-1 receptor-associated kinase (IRAK) family is a group of serine-threonine kinases that regulates various cellular processes via toll-like receptor (TLR)/interleukin-1 receptor (IL1R)-mediated signaling. The IRAK family comprises four members, including IRAK1, IRAK2, IRAK3, and IRAK4, which play an important role in the expression of various inflammatory genes, thereby contributing to the inflammatory response. IRAKs are key proteins in chronic and acute liver diseases, and recent evidence has implicated IRAK family proteins (IRAK1, IRAK3, and IRAK4) in the progression of liver-related disorders, including alcoholic liver disease, non-alcoholic steatohepatitis, hepatitis virus infection, acute liver failure, liver ischemia-reperfusion injury, and hepatocellular carcinoma.

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Radiation pneumonia is a common adverse reaction during radiotherapy in lung cancer patients, which negatively impacts the quality of life and survival of patients. Recent studies have shown that compound Kushen injection (CKI), a traditional Chinese medicine (TCM), has great anti-inflammatory and anticancer potential, but the mechanism is still unclear. We used CiteSpace, the R package "bibliometrix," and VOSviewers to perform a bibliometrics analysis of 162 articles included from the Web of Science core collection.

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Studies show that inflammation induced by cancer is a key factor in carcinogenesis. Here, we sought to assess the relationship between patients with locally advanced rectal cancer (LARC) and the lymphocyte to neutrophil granulocyte ratio (LGR) prior to neoadjuvant chemoradiotherapy (nCRT) and distant metastasis-free survival (DMFS). Using a receiver operating characteristic (ROC) analysis of 326 LARC patients who underwent total mesorectal excision (TME) surgery and neoadjuvant chemoradiotherapy, we were able to determine the ideal LGR cutoff value.

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Esophageal cancer (EC) is a malignant tumour with high morbidity and mortality rates. Recent studies have shown that much progress has been made in the research of radiotherapy in EC. This study aims to provide a comprehensive overview of the knowledge structure and research hotspots of radiotherapy in EC through bibliometrics.

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Background: Xiaozhi formula (XZF) is a practical Chinese herbal formula for the treatment of non-alcoholic fatty liver disease (NAFLD), which possesses an authorized patent certificate issued by the State Intellectual Property Office of China (ZL202211392355.0). However, the underlying mechanism by which XZF treats NAFLD remains unclear.

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Cholestasis is characterized by impaired bile secretion and flow, leading to the accumulation of toxic bile acids in the liver, further causing inflammatory reaction, fibrosis, and ultimately liver transplantation. Although first-line clinical agents such as Ursodeoxycholic acid (UDCA) and Obeticholic acid (OCA) are available, serious side effects still exist. Therefore, pharmacologic treatment of cholestatic liver disease remains challenging.

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Background: Recent studies have shown that XihuangWan (XHW) is a kind of Chinese medicine with significant anti-tumor and anti-inflammatory activities. However, its mechanism for preventing and treating radiation proctitis in rectal cancer patients during radiotherapy remains unclear.

Methods: This study employed the network pharmacology to establish a "drug-active ingredient-target genedisease" network via using TCMSP, SymMap, GeneCard, and OMIM databases.

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Background: Advanced lung cancer that contributes to a heavy burden on medical institutions is the leading cause of cancer-related death and is often accompanied by metabolic disorders. In this study, we aimed to explore the biomarkers of diagnosis and radiotherapy response in non-small-cell lung cancer (NSCLC) patients by plasma lipidomics analysis.

Method: Using triple-quadrupole mass spectrometer analysis, our research characterized the plasma lipid metabolomics profile of 25 healthy controls and 31 advanced NSCLC patients in each of three different radiotherapy phases.

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Background: Asthma is a chronic respiratory disease affecting millions of people worldwide, but early detection can be challenging due to the time-consuming nature of the traditional technique. Machine learning has shown great potential in the prompt prediction of asthma. However, because of the inherent complexity of asthma-related patterns, current models often fail to capture the correlation between data samples, limiting their accuracy.

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Background: Metabolomics is a tool to study the pathogenesis of diseases and their associated metabolites, but there are still insufficient metabolomic studies on severe knee osteoarthritis.To investigate the differences in serum metabolites between healthy populations and knee osteoarthritis (KOA) patients in Southern China using widely targeted metabolomics, and to explore biomarkers and their metabolic pathways that could be associated with the severity of KOA.

Methods: There were 10 healthy individuals in the control group and 32 patients with KOA.

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USP5: Comprehensive insights into structure, function, biological and disease-related implications, and emerging therapeutic opportunities.

Mol Cell Probes

February 2024

Institute of Liver Diseases, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China; Key Laboratory of Liver and Kidney Diseases, Shanghai University of Traditional Chinese Medicine, Ministry of Education, Shanghai, China; Central Laboratory, ShuGuang Hospital Affiliated to Shanghai University of Chinese Traditional Medicine, Shanghai, China; Shanghai Key Laboratory of Traditional Chinese Clinical Medicine, Shanghai, China. Electronic address:

Ubiquitin specific protease 5 (USP5) is a vital deubiquitinating enzyme that regulates various physiological functions by removing ubiquitin chains from target proteins. This review provides an overview of the structural and functional characteristics of USP5. Additionally, we discuss the role of USP5 in regulating diverse cellular processes, including cell proliferation, apoptosis, DNA double-strand damage, methylation, heat stress, and protein quality control, by targeting different substrates.

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Ethnopharmacological Relevance: Traditional Chinese medicine (TCM) holds that non-alcoholic fatty liver disease (NAFLD) belong to the category of "thoracic fullness". Polygonum perfoliatum L. (PPL), a Chinese medicinal herb with the effect of treating thoracic fullness, was recorded in the ancient Chinese medicine book "Supplements to Compendium of Materia Medica".

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Background: Sarcopenia and bone loss are both common in older individuals. However, the association between sarcopenia and bone fractures has not been evaluated longitudinally. In this study, we evaluated the association between computed tomography (CT)-based erector spinae muscle area and attenuation and vertebral compression fracture (VCF) in elderly individuals in a longitudinal study.

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SPP1 as a risk factor for patients with acute on chronic liver failure undergoing liver transplantation.

Int Immunopharmacol

July 2023

Department of Liver Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. Electronic address:

Background: Acute on chronic liver failure (ACLF) is characterized by systemic inflammation and significant mortality, calling for accurate assessment due to the diverse prognosis of liver transplantation (LT).

Methods: 8 patients with ACLF and 4 normal controls (NC) underwent peripheral blood mononuclear cells (PBMCs) transcriptomics, whereas 9 patients with ACLF and 3 NC had hepatic CD45 T cells transcriptomics. Thecandidateindicatorfoundinthetranscriptomicswas confirmedbya retrospective cohort (n = 137) and one prospective cohort (n = 68).

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Article Synopsis
  • Non-alcoholic fatty liver disease (NAFLD) is a serious health issue that can lead to severe liver problems in the future.
  • An herbal medicine called PPL has been discovered to help protect the liver from damage caused by a high-fat diet in mice with NAFLD.
  • Researchers found that PPL affects certain processes in the liver that help break down fats, showing it could be an important treatment for NAFLD.
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Background: Near 70% of hepatocellular carcinoma (HCC) recurrence is early recurrence within 2-year post surgery. Long non-coding RNAs (lncRNAs) are intensively involved in HCC progression and serve as biomarkers for HCC prognosis. The aim of this study is to construct a lncRNA-based signature for predicting HCC early recurrence.

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