5 results match your criteria: "Shanghai Tenth People's Hospital Affiliated to Tongji University Shanghai[Affiliation]"
The splicing factor proline and glutamine rich promotes the growth of osteosarcoma via the c-Myc signaling pathway.
Am J Cancer Res
June 2023
Department of Laboratory Science, School of Medicine, Jiangsu University Zhenjiang 212013, Jiangsu, China.
Splicing factor proline- and glutamine-rich (SFPQ) regulates transcripts in skeletal muscle metabolism and tumorigenesis. As osteosarcoma (OS) is the most common malignant bone tumor characterized by genome instability, such as MYC amplification, this study aimed to investigate the role and mechanism of SFPQ in OS. Expression of SFPQ in OS cell lines and human OS tissues was detected using quantitative real-time PCR, western blot, and fluorescence hybridization (FISH) analyses.
View Article and Find Full Text PDFRelationship between changes in muscle fibers and CMAP in skeletal muscle with different stages of aging.
Int J Clin Exp Pathol
December 2017
Department of Orthopedics, Shanghai Tenth People's Hospital Affiliated to Tongji University Shanghai, China.
Aim: This study aimed to investigate the relationship between the changes of muscle fibers and the changesof peripheral nerve functions (CMAP) with aging.
Methods: Lewis rats enrolled in this study. Muscle biopsy and CMAP of tibialis anterior (TA) were measured.
Impact of different surgical traumas on postoperative ileus in rats and the mechanisms involved.
Int J Clin Exp Med
December 2015
Department of Gastrointestinal Surgery, The First Affiliated Hospital, Wenzhou Medical University Wenzhou, China ; Department of Gastrointestinal Surgery, Shanghai Tenth People's Hospital Affiliated to Tongji University Shanghai, China.
Article Synopsis
- * Four groups of rats were used: a control group, and three trauma groups (intestinal manipulation, ischemia/reperfusion injury, and peritoneal air exposure), with gastrointestinal transit and various biochemical markers analyzed after surgery.
- * Results showed that intestinal manipulation and air exposure led to similar gastrointestinal motility impairment, while ischemia/reperfusion had less impact; however, all types of trauma can lead to POI, suggesting oxidative stress plays a significant role alongside inflammation.
Mitochondrial energy metabolism disorder and apoptosis: a potential mechanism of postoperative ileus.
Int J Clin Exp Med
December 2015
Department of Gastrointestinal Surgery, The First Affiliated Hospital of Wenzhou Medical University Wenzhou 325000, China ; Department of Surgery, Shanghai Tenth People's Hospital Affiliated to TongJi University Shanghai 200072, China.
Article Synopsis
- The study investigates the role of mitochondrial energy metabolism disorders and smooth muscle cell apoptosis in causing postoperative ileus (POI) using a rat model.
- The experimental setup included three groups: naive controls, sham controls, and intestinal manipulation, with various measurements taken to assess gastrointestinal transit and cellular changes.
- Findings indicate that intestinal manipulation resulted in delayed gastrointestinal transit, increased reactive oxygen species, altered energy molecule levels, and abnormal smooth muscle cell and mitochondrial structures, suggesting these factors contribute to the development of POI.
Long noncoding RNA expression profiles of the doxorubicin-resistant human osteosarcoma cell line MG63/DXR and its parental cell line MG63 as ascertained by microarray analysis.
Int J Clin Exp Pathol
August 2016
Department of Orthopaedic Surgery, Shanghai Tenth People's Hospital Affiliated to Tongji University Shanghai 200072, PR China.
Long non-coding RNAs (lncRNAs) are emerging in molecular biology as crucial regulators of cancer. The efficacy of doxorubicin--based chemotherapy in osteosarcoma (OS) is usually limited by acquired drug resistance. To explore the mechanism of chemoresistance of OS in terms of lncRNA, using a human lncRNA-mRNA combined microarray, we identified 3,465 lncRNAs (1,761 up and 1,704 down) and 3,278 mRNAs (1,607 up and 1,671 down) aberrantly expressed in all three sets of doxorubicin-resistant MG63/DXR and their paired parental MG63 cells (fold-change >2.
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