Intestinal nanoparticle delivery and cellular response: a review of the bidirectional nanoparticle-cell interplay in mucosa based on physiochemical properties.

Orally administered nanocarriers play an important role in improving druggability, promoting intestinal absorption, and enhancing therapeutic applications for the treatment of local and systemic diseases. However, the delivering efficiency and cell response in mucosa to orally administered nanocarriers is affected by the physiological environment and barriers in the gastrointestinal tract, the physicochemical properties of the nanocarriers, and their bidirectional interactions. Goblet cells secrete and form extracellular mucus, which hinders the movement of nanoparticles.

Strap-on Buoyant Device to Enhance Gastrointestinal Tract Retention of Felodipine Osmotic Pump Tablets.

Osmotic pump systems require prolonged retention time in the stomach to provide enhanced bioavailability and regulated release, which is quite challenging. This study used a three-dimensional printing (3DP) technique combined with a gastro-retentive floating device (GRFD) to extend the retention of the osmotic pump in the stomach and enhance its bioavailability. The strap-on buoyant device was fabricated by stereolithography 3DP and incorporated a felodipine osmotic pump tablet used in clinical practice, which enabled it to float in the stomach or dissolution media without any floating lag time.

Ultrahigh-strength cellulose nanofiber foams via the synergy of freeze-casting and solvent exchange.

Ultrahigh-strength and lightweight materials have found wide use. However, it is difficult for artificial materials to maintain high strength while being lightweight, as the mechanical properties of most materials are strongly dependent on density. In this study, we combined the methods of freeze casting and solvent exchange to prepare cellulose nanofiber foams with lightweight and ultrahigh strength.

Search for the Exclusive W Boson Hadronic Decays W^{±}→π^{±}γ, W^{±}→K^{±}γ and W^{±}→ρ^{±}γ with the ATLAS Detector.

A search for the exclusive hadronic decays W^{±}→π^{±}γ, W^{±}→K^{±}γ, and W^{±}→ρ^{±}γ is performed using up to 140  fb^{-1} of proton-proton collisions recorded with the ATLAS detector at a center-of-mass energy of sqrt[s]=13  TeV. If observed, these rare processes would provide a unique test bench for the quantum chromodynamics factorization formalism used to calculate cross sections at colliders. Additionally, at future colliders, these decays could offer a new way to measure the W boson mass through fully reconstructed decay products.

Search for the Z Boson Decay to ττμμ in Proton-Proton Collisions at sqrt[s]=13 TeV.

The first search for the Z boson decay to ττμμ at the CERN LHC is presented, based on data collected by the CMS experiment at the LHC in proton-proton collisions at a center-of-mass energy of 13 TeV and corresponding to an integrated luminosity of 138  fb^{-1}. The data are compatible with the predicted background. For the first time, an upper limit at the 95% confidence level of 6.

Sensitive and specific detection of trace Al ions using an upconversion nanoparticle-xylenol orange complex the inner filter effect.

We have developed a novel fluorescence sensor based on upconversion nanoparticles (UCNPs) for the rapid and sensitive detection of trace aluminum ions (Al). The sensor utilizes the inner filter effect (IFE) between the UCNPs and the xylenol orange-aluminum complex (XO-Al), resulting in significant fluorescence quenching at 543 nm upon Al binding. This quenching correlates directly with the Al concentration, allowing for quantitative detection within a range of 0-30 μM and achieving an ultra-low detection limit of 0.

Screening and Predictive Biomarkers for Down Syndrome Through Amniotic Fluid Metabolomics.

Background: Down syndrome (DS) is a congenital disorder caused by the presence of an extra copy of all or part of chromosome 21. It is characterized by significant intellectual disability, distinct facial features, and growth and developmental challenges. The utilization of metabolomics to analyze specific metabolic markers in maternal amniotic fluid may provide innovative tools and screening methods for investigating the early pathophysiology of trisomy 21 at the functional level.

Single-cell and spatial transcriptome characterize coinhibitory cell-cell communications during histological progression of lung adenocarcinoma.

Introduction: Lung adenocarcinoma, a prevalent and lethal malignancy globally, is characterized by significant tumor heterogeneity and a complex tumor immune microenvironment during its histologic pattern progression. Understanding the intricate interplay between tumor and immune cells is of paramount importance as it could potentially pave the way for the development of effective therapeutic strategies for lung adenocarcinoma.

Methods: In this study, we run comparative analysis of the single-cell transcriptomic data derived from tumor tissues exhibiting four distinct histologic patterns, lepidic, papillary, acinar and solid, in lung adenocarcinoma.

Meta-analysis of the effects of probiotics on hyperlipidemia.

Background: The potential role of probiotics in mitigating hyperlipidemia has garnered increasing evidence, yet the specific mechanisms warrant further investigation.

Objective: This study aimed to examine the alterations in short-chain fatty acids (SCFAs), a hypothesized lipid-lowering mechanism of probiotics, in animal models and to evaluate the lipid-lowering effects of probiotics on hyperlipidemic animal models through a meta-analysis of preclinical experiments. Methods: A comprehensive search of PubMed, Web of Science, EMBASE, Cochrane Library and Google Scholar up to June 2024 yielded nine studies that met the inclusion criteria (INPLASY registration number: No.

Bright and Stable Cyan Fluorescent RNA Enables Multicolor RNA Imaging in Live Escherichia coli.

Fluorescent RNAs (FRs), which are RNA aptamers that bind and activate their cognate small fluorogenic dyes, have provided a particularly useful approach for imaging RNAs in live cells. Although the color palette of FRs is greatly expanded, a bright and stable cyan FR with good biocompatibility and biorthogonality with currently available FRs remains desirable but is not yet developed. Herein, the development of Myosotis is described, an RNA aptamer that emits bright cyan fluorescence upon binding a novel GFP chromophore-like fluorophore called DBT.

Gentle Rhodamines for Live-Cell Fluorescence Microscopy.

Rhodamines have been continuously optimized in brightness, biocompatibility, and color to fulfill the demands of modern bioimaging. However, the problem of phototoxicity caused by the excited fluorophore under long-term illumination has been largely neglected, hampering their use in time-lapse imaging. Here we introduce cyclooctatetraene (COT) conjugated rhodamines that span the visible spectrum and exhibit significantly reduced phototoxicity.

SbO(OH)(IO): The First Polar Sb-Iodate with a Strong Second-Harmonic Generation Response and a Wide Bandgap.

Widening the bandgaps while maintaining a strong second harmonic generation response has always been a research hotspot in the field of nonlinear optical iodate materials. A strategy involving covalent bonding is proposed that leverages the high valent later main group cation to construct iodates with predominantly covalent interactions. By using BiO(IO) as a template, the first Sb-containing polar iodate, SbO(OH)(IO) is successfully isolated.

Review of Laser Powder Bed Fusion's Microstructure and Mechanical Characteristics for Al-Ce Alloys.

As a new alloy manufacturing method that can break through the limitations of molds to manufacture fine parts, laser powder bed fusion has recently become a common process for producing aluminum alloys. In the fields of aerospace or automotive, aluminum alloys with both good printability and good mechanical performance in high-temperature conditions are greatly demanded, and the Al-Ce alloy is one of the alloys with significant potential. Therefore, systematic research on the additive manufacturing of Al-Ce alloys is still being explored.

Elucidating the Fundamental Process of Methyl-(5hydroxymethyl) Furan-2-Carboxylate Toxin Biosynthesis in Causing Maize Leaf Spot.

Maize leaf spot, which is caused by (Wakkre) Boedijn, was epidemic in the maize-growing regions of northeastern and northern China in the mid-1990s, where it led to large yield losses. Since then, the epidemic has evolved into a kind of common disease. In recent years, however, a tendency of becoming an epidemic disease again has been observed in some areas in China due to significant changes in climate, farming, systems and crop varieties.

Efficient Neural Decoding Based on Multimodal Training.

Background/objectives: Neural decoding methods are often limited by the performance of brain encoders, which map complex brain signals into a latent representation space of perception information. These brain encoders are constrained by the limited amount of paired brain and stimuli data available for training, making it challenging to learn rich neural representations.

Methods: To address this limitation, we present a novel multimodal training approach using paired image and functional magnetic resonance imaging (fMRI) data to establish a brain masked autoencoder that learns the interactions between images and brain activities.

Flexible Magnetoelectric Fiber for Self-Powered Human-Machine Interactive.

Flexible large strain sensors are an ideal choice for monitoring human motion, but the current use of flexible strain gauges is hindered by the need for external power sources and long-term operation requirements. Fiber-based sensors, due to their high flexibility, excellent breathability, and the ease with which they can be embedded into everyday clothing, have the potential to become a novel type of wearable electronic device. This paper proposes a flexible self-powered strain sensing material based on the electromagnetic induction effect, composed of a uniform mixture of Ecoflex and NdFeB, which has good skin-friendliness and high stretchability of over 100%.

Anaerobic treatment of nitrogenous industrial organic wastewater by carbon-neutral processes integrated with anaerobic digestion and partial nitritation/anammox: Critical review of current advances and future directions.

Anaerobic digestion combined with partial nitritation/anammox technology holds promising potential for the carbon-neutral treatment of nitrogenous industrial organic wastewater, boasting remarkable advantages in effective removal of both organic matters and nitrogen, bio-energy recovery and carbon emission reduction. This study provides a concise overview of the development and advantages of anaerobic digestion combined with partial nitritation/anammox technology for treating nitrogenous industrial organic wastewater. The process excels in removing organic matter and nitrogen, recovering bio-energy, and reducing carbon emissions, compared to traditional physicochemical and biological methods.