Flexible Pressure Sensors for Optimizing Pressure Garment Therapy in Periarticular Scar Treatment: Preclinical and Clinical Applications.

Pressure garment therapy is a common strategy for controlling hypertrophic scars; however, insufficient pressure due to reduced elasticity or joint movement limits its effectiveness around joints. The FlexiForce B201 pressure sensor offers precise pressure measurements, thereby demonstrating a promising solution. This study used a Bama pig scar model with an untreated group, a pressure garment group, and a pressure monitoring group that was treated with FlexiForce B201 sensors and pressure garments.

Canagliflozin Attenuates Podocyte Inflammatory Injury through Suppressing the TXNIP/NLRP3 Signaling Pathway in Diabetic Kidney Disease Mice.

Diabetic kidney disease (DKD), a leading cause of end-stage renal disease (ESRD), poses a serious threat to global health. Aseptic inflammation and pyroptosis of podocytes are crucial factors contributing to the pathogenesis and progression of DKD. Sodium-glucose cotransporter 2 inhibitors (SGLT2i), a novel class of antidiabetic agents widely used in clinical settings, may exert a protective effect on podocyte injury, although the underlying mechanisms remain poorly understood.

A Novel Approach for Suprachoroidal Space Injection: An Experimental Evaluation.

Purpose: This study aims to describe an innovative suprachoroidal space injection technique using a combination of 30 G and 22 G needles attached to a 1 ml injector. The efficacy and applicability of this technique in suprachoroidal injections are evaluated.

Methods: In this study, we conducted both and injection experiments using isolated porcine eyes and live SD rats, respectively.

Chinese Association of Ultrasound in Medicine and Engineering, Superficial Organs and Peripheral Vessels Committee Expert Consensus on Selected Common Clinical Issues in Parathyroid Ultrasound (2024 Edition).

Parathyroid ultrasound is widely used in clinical practice and plays a crucial role in the diagnosis and treatment of parathyroid diseases. Nevertheless, ultrasound physicians frequently encounter a number of challenges and doubts in their professional practice. For this reason, Superficial Organs and Peripheral Vessels Committee of Chinese Association of Ultrasound in Medicine and Engineering has formulated the expert consensus on certain common clinical problems of parathyroid ultrasound based on the current research progress and clinical experience, in order to guide the clinical practice.

Analysis of cellular senescence-related genes in calcified aortic valve disease and the potential therapeutic role of β-Carotene.

Objective: Calcific aortic valve disease (CAVD) is a progressive, age-related degenerative disease characterized by the accumulation of calcium deposits in the aortic valve. We aim to screen key genes associated with cellular senescence (CS) in CAVD.

Methods: The GSE12644 and GSE51472 datasets from the GEO database was utilized in this study, and differentially expressed genes (DEGs) were identified using the "limma" R package.

Upregulation of Receptor Interacting Protein 1 Induced by UVB Contributes to Photodamage of the Skin Through NF-κB Pathway In Vivo and In Vitro.

Background: Ultraviolet (UV) B can reach the epidermis and superficial dermis of the skin, inducing sunburn, inflammation, immunosuppression, cancer, and so on. Our former research found that receptor interacting protein (RIP) 1 could be upregulated in human dermal fibroblasts(HDFs) after UVB irradiation by using two-dimensional gel electrophoresis and matrix-assisted laser desorption/ionization time of flight mass spectrometry techniques. Besides, our further research found that RIP1 was involved in the UVB-induced production of ROS and MMPs in HDFs.

Preoperative computed tomography-guided soft hook-wire localization for multiple pulmonary nodules.

Background: While there have been prior reports on pulmonary nodule (PN) localization through computed tomography (CT)-guided soft hook-wire (SHW) placement, there remains a dearth of studies specifically focused on the CT-guided SHW localization of multiple PNs. This study was thus designed to specifically evaluate the efficacy and safety of this localization strategy in patients with multiple PNs.

Methods: In total, 43 consecutive patients with multiple PNs underwent CT-guided SHW localization followed by video-assisted thoracoscopic surgery (VATS) to resent these PNs in our hospital between January 2022 and December 2022.

The Roles and Functions of Ergothioneine in Metabolic Diseases.

The global prevalence of metabolic diseases is on the increase, and it has become a significant threat to the health and lives of individuals. Ergothioneine (EGT) is a natural betaine amino acid found in various foods, particularly mushrooms. EGT cannot be synthesized by mammals; it is absorbed into small intestinal epithelial cells by a cationic protein, the novel organic cation transporter 1 (OCTN1), and transported to certain organs.

Comparative Effectiveness of Different Opioid Regimens, in Daily Dose or Treatment Duration, Prescribed at Surgical Discharge: a Systematic Review and Meta-Analysis.

Background: Opioids are prescribed for postsurgical pain management, but a balance between achieving adequate pain control and minimising opioid-related harm is required. This study aimed to investigate the effectiveness of different opioid regimens, in daily dose or treatment duration, prescribed at surgical discharge.

Methods: A systematic search of MEDLINE, EMBASE, CENTRAL, and ICTRP was performed from inception to 12 January 2025.

Elevated prolactin levels before endometrial transformation negatively impact reproductive outcomes in frozen embryo transfer cycles under hormone replacement therapy.

Introduction: Prolactin (PRL) plays a key role in the regulation of reproductive functions. However, its impact on outcomes in infertility women undergoing assisted reproductive technology remains unclear. This study aimed to examine the relationship between PRL levels and reproductive outcomes in frozen embryo transfer (FET) cycles under hormone replacement therapy (HRT).

Fluorescence intensity of parathyroid glands in thyroid and parathyroid surgery: a near-infrared autofluorescence study.

Objective: Near-infrared autofluorescence (NIRAF) imaging shows promise in identifying parathyroid gland (PG) during surgery. However, the clinical application of NIRAF faces challenges due to the heterogeneous fluorescence intensity (FI) of PGs observed in different thyroid and parathyroid diseases. This study aimed to evaluate the effectiveness of NIRAF in PG detection and to analyze the FI of PGs in patients with various thyroid and parathyroid diseases.

The lower rate of bone and joint infection in patients with open extremity fractures associated with vaccination prior to injury: a propensity-matched cohort study.

Background: Vaccines could strengthen the innate immune system in addition to conferring protection against their target pathogen via vaccine-induced immunomodulation, a phenomenon termed trained immunity. The purpose of the present study was to determine whether vaccination prior to injury is associated with a lower rate of bone and joint infections (BJIs) in patients with open extremity fractures.

Methods: Patients with open extremity fractures treated at one hospital between January 2010 and December 2019 were identified.

Bridging the Gap: Parental Supervision as a Mediator Between Home Environment and Unintentional Injuries in Children Under 3 Years.

Objectives: Unintentional home injuries pose a serious risk to children under 3 years. While parental supervision and home environment are key factors influencing these injuries, few studies have explored the correlation between them. This study aimed to examine the relationship between home environment, parental supervision, and unintentional home injuries, and to investigate whether parental supervision mediates this relationship.

Effects of semaglutide in patients with chronic ankle instability: evidence from a prospective cohort.

Background: Whether patients with chronic ankle instability (CAI) can benefit from weight loss yielded by using glucagon-like peptide-1 receptor agonists (GLP1-RAs) has remained unclear.

Methods: In this observational study, we recruited more than 2000 adults with CAI according to the selection criteria proposed by International Ankle Consortium with at least two-year follow up from three medical centers. The primary endpoint was the change from baseline of the Foot and Ankle Ability Measure (FAAM) sports subscale at the last follow up.

Selenium-Loaded Porous Silica Nanospheres Improve Cardiac Repair After Myocardial Infarction by Enhancing Antioxidant Activity and Mitophagy.

Myocardial infarction (MI) is the leading cause of death globally, often resulting to significant loss of cardiac function. A key factor in the pathological progression of MI is the excessive generation of reactive oxygen species (ROS) by dysfunctional mitochondria. However, no antioxidant therapy has been approved for clinical treatment of MI to date.

FLRT3 Overexpression Attenuates Ischemia-Reperfusion Induced Vascular Hyperpermeability and Lung Injury Through RND3.

Purpose: Pulmonary ischemia/reperfusion injury (IRI) causes endothelial barrier dysfunction and increased vascular permeability. Fibronectin leucine-rich transmembrane protein-3 (FLRT3) is known to regulate endothelial cell function, but its role in pulmonary IRI remains unexplored.

Methods: We established both a mouse lung I/R model and a hypoxia/reoxygenation (H/R) cell culture model using human pulmonary microvascular endothelial cells (HPMECs).

Increased Risk of Dermatomyositis in Patients with Psoriasis: A Retrospective Cohort Study.

Purpose: This study aimed to investigate the risk of dermatomyositis among patients with psoriasis in a large population.

Patients And Methods: Individuals aged ≥20 years with records in the TriNetX database from January 1, 2002 to December 31, 2022 were included. Diagnoses of psoriasis, non-psoriasis, dermatomyositis, and associated comorbidities were established using the International Classification of Diseases, 10th Revision, Clinical Modification (ICD-10-CM) code.

Nanohybrid Hydrogel with Dual Functions: Controlled Low-Temperature Photothermal Antibacterial Activity and Promoted Regeneration for Treating MRSA-Infected Bone Defects.

Methicillin-resistant Staphylococcus aureus (MRSA)-related bone defects pose significant clinical challenges due to treatment failures. Here, an injectable nanohybrid hydrogel (FND-ZHD) is developed that combines controlled low-temperature photothermal antibacterial therapy with enhanced bone regeneration. The hydrogel uses Pluronic F-127 as the matrix, incorporating polydopamine-coated nano-hydroxyapatite and zinc oxide nanoparticles encapsulated with polydopamine and hyaluronic acid, forming a sophisticated nanostructured composite.

A critical role of N-acetylation of cytidine in mRNA by NAT10 in T cell expansion and antiviral immunity.

Following activation, naive T cells exit quiescence and require global translation for rapid expansion, yet the underlying mechanisms remain unclear. Here, we show that during T cell activation, cells upregulate the expression of N-acetyltransferase 10 (NAT10), an enzyme responsible for N-acetylcytidine (acC) modification of mRNAs. acC-modified Myc mRNAs show higher translation efficiency, enabling rapid synthesis of MYC protein and supporting robust T cell expansion.

Development of an MRI based artificial intelligence model for the identification of underlying atrial fibrillation after ischemic stroke: a multicenter proof-of-concept analysis.

Background: Atrial fibrillation (AF) represents a major risk factor of ischemic stroke recurrence with serious management implications. However, it often remains undiagnosed due to lack of standard or prolonged cardiac rhythm monitoring. We aim to create a novel end-to-end artificial intelligence (AI) model that uses MRI data to rapidly identify high AF risk in patients who suffer from an acute ischemic stroke.

Atypical rat bite fever associated with knee joint infection in a Chinese patient: a case report.

Background: Rat bite fever (RBF) is a rare zoonosis transmitted from rodents to humans through bites and scratches. However, diagnosis and treatment of atypical clinical cases can be challenging.

Case Presentation: Herein, we report an atypical case of RBF with unilateral knee joint infection caused by Streptobacillus moniliformis.

3D bioprinted functional scaffold based on synergistic induction of iprf and laponite exerts efficient and personalised bone regeneration via MiRNA-mediated TGF-β/Smads signaling.

Background: Limited stem cells, low vascularization efficiency and weak osteoinductive activity plague the repair and reconstruction of bone defects with cell-free scaffolds.

Methods: Herein, injectable platelet-rich fibrin (i-PRF) was loaded into a methacrylated alginate/gelatin-methylcellulose (AGM) bioink system and constructed a porous hydrogel scaffold by three-dimensional bioprinting. The addition of nanosilicate-laponite (Lap) further enhanced this scaffold and synergized with i-PRF to promote efficient and personalized cranial regeneration.