Voluntary running wheel exercise induces cognitive improvement post traumatic brain injury in mouse model through redressing aberrant excitation regulated by voltage-gated sodium channels 1.1, 1.3, and 1.6.

Traumatic brain injury (TBI) leads to disturbed brain discharge rhythm, elevated excitability, anxiety-like behaviors, and decreased learning and memory capabilities. Cognitive dysfunctions severely affect the quality of life and prognosis of TBI patients, requiring effective rehabilitation treatment. Evidence indicates that moderate exercise after brain injury decreases TBI-induced cognitive decline.

Effects of 3-aminobenzamide on ventricular function in infarct heart assessed by quantitative tissue velocity imaging.

Background: Coronary artery disease is a common cardiovascular disease that often causes myocardial infarction (MI), which, after a certain period, can develop into congestive heart failure, resulting in high mortality and mortality rates. Overactivation of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) has recently been considered a final common effector in myocardial ischemia/reperfusion injury. The aim of this study was to have a comprehensive understanding of the beneficial effects of 3-aminobenzamide (3-AB) on postinfarct myocardial injuries by inhibiting PARP.

Coronary flow velocity pattern and recovery of regional left ventricular function: the relationship observed in patients with reperfused acute myocardial infarction.

Coronary flow velocity pattern (CFVP) recorded within 3 days of percutaneous coronary intervention (PCI) has been reported to be useful in predicting left ventricular (LV) function. The aim of this prospective study was to investigate, via transthoracic Doppler echocardiography, whether the relationship between CFVP and recovery of LV function persists. Our study group comprised 37 patients with 1st anterior-wall acute myocardial infarction who underwent successful PCI for lesions in the left anterior descending coronary artery (LAD).