1 results match your criteria: "Shanghai Qidong Liver Cancer Institute[Affiliation]"
Combined pre-S deletion and core promoter mutations related to hepatocellular carcinoma: A nested case-control study in China.
Hepatol Res
January 2011
Department of Gastroenterology, Zhongshan Hospital, Fudan University, Shanghai Qidong Liver Cancer Institute, Qidong, Jiangsu Province, China.
Article Synopsis
- The study aimed to explore how factors like HBV DNA levels, genotypes, and specific mutations affect the development of hepatocellular carcinoma (HCC) in males from Qidong, China.
- Researchers evaluated health data from 2,387 HBV-positive males over ten years, comparing 196 patients who developed HCC to 323 controls.
- Findings revealed that high HBV DNA levels, specific mutations, and elevated alpha-fetoprotein (AFP) levels were significant risk factors for developing HCC, with a combination of mutations posing an even greater risk.