15 results match your criteria: "Shanghai No. 8 People's Hospital[Affiliation]"
[Retracted] Tripartite motif‑containing 14 regulates cell proliferation and apoptosis in cervical cancer via the Akt signaling pathway.
Mol Med Rep
November 2023
Department of Clinical Laboratory, Shanghai No. 8 People's Hospital, Shanghai 200235, P.R. China.
Following the publication of this paper, it was drawn to the Editor's attention by a concerned reader that the GAPDH control western blotting data shown in Fig. 2B were strikingly similar to data appearing in different form in Fig. 1E in another article written by different authors at different research institutes [Liang T, Ye X, Liu Y, Qiu X, Li Z, Tian B and Yan D: FAM46B inhibits cell proliferation and cell cycle progression in prostate cancer through ubiquitination of β‑catenin.
View Article and Find Full Text PDFTripartite motif‑containing 14 regulates cell proliferation and apoptosis in cervical cancer via the Akt signaling pathway.
Mol Med Rep
December 2020
Department of Clinical Laboratory, Shanghai No. 8 People's Hospital, Shanghai 200235, P.R. China.
Tripartite motif‑containing (TRIM) 14 is a protein of the TRIM family. Studies have indicated that TRIM14 may be used as an oncogene in tumor cells, such as osteosarcoma, non‑small cell lung cancer and breast cancer through different pathways. However, the functions of TRIM14 in cervical cancer cells remain unclear.
View Article and Find Full Text PDFCircNOL10 Acts as a Sponge of miR-135a/b-5p in Suppressing Colorectal Cancer Progression via Regulating KLF9.
Onco Targets Ther
June 2020
Department of General Surgery, Shanghai No.8 People's Hospital, Shanghai, People's Republic of China.
Article Synopsis
- CircNOL10 is identified as a crucial regulator in colorectal cancer (CRC), showing decreased levels in CRC tissues and correlating with poorer patient outcomes.
- Experimental results demonstrated that overexpression of circNOL10 reduced CRC cell proliferation, migration, and invasion, effects that were reversed by the overexpression of specific miRNAs (miR-135a-5p and miR-135b-5p).
- The study suggests that circNOL10 hinders CRC progression by acting as a sponge for these miRNAs and regulating KLF9 expression, highlighting its potential as a therapeutic target in CRC treatment.
ACE2 exhibits protective effects against LPS-induced acute lung injury in mice by inhibiting the LPS-TLR4 pathway.
Exp Mol Pathol
April 2020
Department of Respiratory and Critical Care Medicine, Shanghai General Hospital, Shanghai JiaoTong University School of Medicine, Shanghai 200080, PR China. Electronic address:
Article Synopsis
- This study explored how angiotensin converting enzyme 2 (ACE2) protects against acute lung injury (ALI) caused by lipopolysaccharide (LPS) in mouse models and cell cultures.
- Mice with LPS-induced ALI showed reduced levels of ACE2, increased lung damage, and heightened inflammation, but ACE2 treatment improved lung function and reduced inflammation.
- The research indicates that ACE2 plays a crucial role in balancing the renin-angiotensin system and mitigating inflammation during lung injury, and that combining ACE2 treatment with specific inhibitors enhances its protective effects.
prevents apoptosis in colorectal cancer cells via the ANO1 pathway.
Cancer Manag Res
October 2019
Department of Clinical Laboratory, Shanghai No. 8 People's Hospital, Shanghai, China.
Objective: : Chemotherapy failure derived from drug resistance is the most important reason causing the recurrence in colorectal cancer patients. Therefore, it is necessary to shed light on the mechanism of chemotherapy resistance in colorectal cancer patients.
Methods: : We looked into the contribution of and ANO1 to chemoresistance in the human colorectal carcinoma cell lines.
Treadmill training improves neurological deficits and suppresses neuronal apoptosis in cerebral ischemic stroke rats.
Neural Regen Res
August 2019
Department of Neurology, Shanghai No. 8 People's Hospital, Shanghai, China.
Rehabilitation training is believed to be beneficial to patients with stroke, but its molecular mechanism is still unclear. Rat models of cerebral ischemic stroke were established by middle cerebral artery occlusion/reperfusion, and then received treadmill training of different intensities, twice a day for 30 minutes for 1 week. Low-intensity training was conducted at 5 m/min, with a 10-minute running, 10-minute rest, and 10-minute running cycle.
View Article and Find Full Text PDF[Effects of low level laser combined with basic periodontal therapy on cytokines and LPS, leptin in gingival crevicular fluid of diabetes mellitus complicated with chronic periodontitis patients].
Shanghai Kou Qiang Yi Xue
December 2018
Department of Stomatology, Shanghai No.8 People's Hospital. Shanghai 200235, China.
Article Synopsis
- This study examines how low-level laser therapy used alongside standard periodontal treatment affects certain inflammatory markers and hormones in diabetic patients with chronic periodontitis.
- A total of 80 patients were divided into two groups: one received standard treatment while the other got additional laser therapy, with various health markers monitored before and after treatment.
- Results showed that the laser therapy group had significantly better outcomes in reducing inflammation and improving health markers compared to the control group, indicating that the combination therapy is beneficial for managing periodontitis in diabetic patients.
[Effect of overdose fluoride on the expression of TGF-β3 in rat incisor].
Shanghai Kou Qiang Yi Xue
February 2018
Department of Stomatology, Shanghai No.8 People's Hospital. Shanghai 201500, China.
Purpose: To observe the effect of overdose fluoride on the expression of TGF-β3 in rat incisor and to explore the possible mechanism of dental fluorosis． METHODS: Twenty Wistar rats were randomly divided into 2 groups. The animals were maintained in standard environmental conditions with free access to food and water (control group) or water added with 100mg/L F (experimental group). The rats were killed at the end of 8th week.
View Article and Find Full Text PDFmiR-486-5p regulates the migration and invasion of colorectal cancer cells through targeting PIK3R1.
Oncol Lett
May 2018
Department of General Surgery, The Affiliated Shanghai No. 10 People's Hospital, Nanjing Medical University, Shanghai 200072, P.R. China.
Article Synopsis
- The study focused on the role of microRNA-486-5p in colorectal cancer (CRC) by analyzing tissue samples from patients, revealing that miR-486-5p levels were significantly lower in tumor tissues compared to normal tissues.
- Experiments with SW620 CRC cells showed that adding miR-486-5p mimics reduced the cells' ability to migrate and invade, suggesting a potential suppressive effect on cancer progression.
- Further analysis indicated that miR-486-5p may inhibit the activation of the AKT signaling pathway by targeting specific proteins, positioning it as a potential therapeutic target for CRC.
[Meliorated surgical procedure of Winograd for recurrent onychocryptosis].
Zhonghua Yi Xue Za Zhi
July 2012
Department of Orthopedics, Shanghai No. 8 People's Hospital, Shanghai 200235, China.
Article Synopsis
- The study aimed to evaluate an improved surgical method for treating recurrent onychocryptosis, which is commonly known as ingrown toenails.
- A total of 145 cases were analyzed over an average follow-up period of nearly 29 months, with no instances of recurrence reported.
- The findings indicate that the modified procedure is both statistically significant and clinically effective for managing this condition.
Identification of acute self-limited hepatitis B among patients presenting with hepatitis B virus-related acute hepatitis: a hospital-based epidemiological and clinical study.
J Int Med Res
March 2010
Research Unit of Liver Disease, Shanghai No. 8 People's Hospital, Jiangsu University, Shanghai, China.
Article Synopsis
- The study focused on identifying acute self-limited hepatitis B (ASL-HB) in patients with hepatitis B virus-related acute hepatitis, analyzing data from 220 patients.
- Among the 164 diagnosed with acute hepatitis B (AHB), 160 were confirmed as ASL-HB, with a very low percentage progressing to chronic hepatitis B or complications.
- The study noted that AHB cases outnumbered acute infections from hepatitis A and E, with similar symptoms across all types but distinct differences in biochemical parameters; additionally, AHB infections did not show a seasonal peak like HA and HE.
[Effect of neoadjuvant chemoradiotherapy on the healing of anastomosis following low anterior resection in locally advanced rectal cancer].
Zhonghua Wai Ke Za Zhi
November 2009
Department of Colorectal Surgery, Shanghai No.8 People's Hospital, Shanghai 200233, China.
Objective: To investigate the effect of the neoadjuvant chemoradiotherapy (NCR) on the healing of anastomosis following low anterior resection in patients with locally advanced rectal cancer.
Methods: Between May 2001 and August 2007, 192 patients with T3 and T4 low rectal cancer (distance from the tumor to anal verge View Article and Find Full Text PDF
[Exploration on neoadjuvant chemoradiation in the treatment for locally advanced low rectal cancer].
Zhonghua Wai Ke Za Zhi
October 2009
Department of Colorectal Surgery, Shanghai No. 8 People's Hospital, Shanghai 200233, China.
Objective: To explore the possibility of further improvement of the efficacy of neoadjuvant chemoradiotherapy in locally advanced lower rectal cancer and the management of patients with clinical complete regression.
Methods: From May 2001 to August 2007, 192 cases with locally advanced lower rectal cancer (T3/T4 or N(+)) received preoperative radiotherapy 40 - 46 Gy/20 - 23 fractions and concomitant oral capecitabine 625 mg/m(2) bid for 10 weeks prior to surgery. Curative resection with total mesorectal excision (TME) was carried out 6 weeks after the end of radiation.
Clinical, biochemical, immunological and virological profiles of, and differential diagnosis between, patients with acute hepatitis B and chronic hepatitis B with acute flare.
J Gastroenterol Hepatol
November 2008
Research Unit of Liver Disease, Shanghai No. 8 People's Hospital, Shanghai, China.
Article Synopsis
- The study aims to find alternative laboratory parameters to differentiate between acute hepatitis B and chronic hepatitis B with an acute flare, particularly in regions where HBV infection is common.
- Significant differences were observed in clinical and laboratory findings between patients with acute self-limited hepatitis B and chronic hepatitis B, notably in the levels of HBV-DNA, HBeAg, and alpha-fetoprotein.
- Combining IgM anti-HBc with other markers like HBV-DNA and HBeAg enhanced diagnostic accuracy, achieving a high predictive value for diagnosing acute self-limited hepatitis B.
[Childhood upper respiratory infection caused by Mycoplasma pneumoniae].
Zhongguo Dang Dai Er Ke Za Zhi
June 2006
Department of Pediatrics, Shanghai No.8 People's Hospital, Shanghai 200233, China.
Objective: This study was designed to investigate the prevalence, clinical characteristics and outcome of upper respiratory infection (URI) caused by Mycoplasma pneumoniae (MP) in children.
Methods: Pharyngeal cultures for MP antibody were performed in 960 children with acute URI. The samples were randomly collected from the outpatient room or emergency room (Observed group).