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Exosomes derived from cardiomyocytes promote cardiac fibrosis via myocyte-fibroblast cross-talk.

Am J Transl Res

December 2018

Department of Cardiovascular Disease, Xinhua Hospital, School of Medicine, Shanghai Jiaotong University 1665 Kongjiang Street, Shanghai 200092, P. R. China.

Cardiac fibrosis is primarily mediated by activated fibroblasts. However, cardiomyocytes have also been implicated in facilitating the fibrotic response. We aimed to explore how cardiomyocyte-derived exosomes affect fibroblasts.

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