26,538 results match your criteria: "Shanghai Jiaotong University[Affiliation]"
Radiat Oncol
December 2024
Department of Radiation Oncology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200025, China.
Purpose: To investigate the early predictive value of dynamic magnetic resonance imaging (MRI)-based radiomics for progression and prognosis in locally advanced cervical cancer (LACC) patients treated with concurrent chemoradiotherapy (CCRT).
Methods And Materials: A total of 111 LACC patients (training set: 88; test set: 23) were retrospectively enrolled. Dynamic MR images were acquired at baseline (MRI), before brachytherapy delivery (MRI) and at each follow-up visit.
Bone Marrow Transplant
December 2024
Department of Hematology, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200080, China.
In this real-world study, 153 adult T-cell lymphoblastic lymphoma (T-LBL) patients from sixteen centers in Shanghai were enrolled. Out of them, 103 (67.3%) achieved complete remission (CR).
View Article and Find Full Text PDFNPJ Precis Oncol
December 2024
College of Computer Science and Electronic Engineering, Hunan University, Changsha, China.
Spread through air spaces (STAS) is a distinct invasion pattern in lung cancer, crucial for prognosis assessment and guiding surgical decisions. Histopathology is the gold standard for STAS detection, yet traditional methods are subjective, time-consuming, and prone to misdiagnosis, limiting large-scale applications. We present VERN, an image analysis model utilizing a feature-interactive Siamese graph encoder to predict STAS from lung cancer histopathological images.
View Article and Find Full Text PDFFree Radic Biol Med
December 2024
Genetic and Prenatal Diagnosis Center, Department of Gynecology and Obstetrics, First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, China. Electronic address:
Ovarian cancer remains a significant challenge due to the lack of effective treatment and the resistance to conventional therapies. Ferroptosis, a form of regulated cell death characterized by iron-depend and lipid peroxidation, has emerged as a potential therapeutic target in cancer. Ovarian cancer has been reported to exert an "iron addiction" phenotype which makes it is susceptible to ferroptosis inducers.
View Article and Find Full Text PDFJ Hazard Mater
December 2024
Key Laboratory of the Public Health Safety, Ministry of Education, Department of Environmental Health, School of Public Health, Fudan University, Shanghai 200032, China; Key Laboratory of Health Technology Assessment, National Health Commission of the People's Republic of China, Fudan University, Shanghai 200032, China; Center for Water and Health, School of Public Health, Fudan University, Shanghai 200032, China. Electronic address:
Extensive evidence suggests a correlation between environmental pollutants, specifically perfluoroalkyl and polyfluoroalkyl substances (PFAS) and non-alcoholic fatty liver disease (NAFLD). This study aims to investigate the association and underlying mechanisms of PFAS-induced NAFLD in adolescents by employing a comprehensive approach of population-based studies, toxicogenomics, and animal models. A total of 2014 freshmen from Dali University were recruited for this study, with 1694 participants undergoing serum testing for PFAS exposure.
View Article and Find Full Text PDFJ Nutr Sci
December 2024
State Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Although dietary factors have been examined as potential risk factors for liver cancer, the evidence is still inconclusive. Using a diet-wide association analysis, our research evaluated the associations of 126 foods and nutrients on the risk of liver cancer in a Chinese population. We obtained the diet consumption of 72,680 women in the Shanghai Women's Health Study using baseline dietary questionnaires.
View Article and Find Full Text PDFTechnol Cancer Res Treat
December 2024
Department of Urology, Shanghai Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Clear cell renal cell carcinoma (ccRCC) is a highly lethal urinary malignancy with poor overall survival (OS) rates. Integrating computer vision and machine learning in pathomics analysis offers potential for enhancing classification, prognosis, and treatment strategies for ccRCC. This study aims to create a pathomics model to predict OS in ccRCC patients.
View Article and Find Full Text PDFAm J Clin Nutr
December 2024
Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200025, China; Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai National Center for Translational Medicine, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200025, China. Electronic address:
Background: Accurate monitoring of energy balance is essential for effective weight management, but the role of energy excretion is often neglected.
Objective: This study aimed to develop and validate a standardized method for assessing energy excretion using dye-labeled meal replacement bars with consistent and stable ingredients.
Methods: We utilized baseline data from a registered cross-over trial involving twelve healthy adults (7 females, 5 males) with a body mass index of 18-25 kg/m.
Life Sci
December 2024
Department of Pharmacy, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200092, China. Electronic address:
Pathological vascular remodeling (VR) is characterized by structural and functional alterations in the vascular wall resulting from injury, which significantly contribute to the development of cardiovascular diseases (CVDs). The vascular wall consists primarily of endothelial cells (ECs), vascular smooth muscle cells (VSMCs), and adventitial fibroblasts (AFs), whose interactions are crucial for both the formation of the vascular system and the maintenance of mature blood vessels. Disruptions in the communication between these cell types have been implicated in the progression of VR.
View Article and Find Full Text PDFEndoscopy
January 2025
Gastroenterology, Shanghai Jiaotong University School of Medicine Xinhua Hospital, Shanghai, China.
Breast
December 2024
Department of Epidemiology & State Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200032, China; School of Public Health, Shanghai Jiaotong University School of Medicine, Shanghai, 200025, China; Health Management Center, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200127, China.
To better understand global patterns, chronological changes, and international comparisons of female breast cancer survival, we reviewed published data from population-based cancer registries worldwide. Using PubMed, Embase, Web of Science, SEER, and SinoMed, a comprehensive literature search was conducted for female breast cancer survival from the population-based cancer registries through 31 December 2023. Observed, relative, and net survival rates and their corresponding age-standardized survival rates since the 1990s were collected and further stratified by prognostic factors.
View Article and Find Full Text PDFJ Colloid Interface Sci
December 2024
Shanghai Key Laboratory of Orthopaedic Implants, Department of Orthopaedic Surgery, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, 200041 Shanghai, China. Electronic address:
Biological lubricating materials play a crucial role in normal human activities due to their extremely low coefficients of friction (COFs). However, synthetic friction materials typically exhibit higher friction coefficients and wear rates compared to natural lubricating materials. To address this issue, we propose a novel lubrication strategy: reducing the friction coefficient of synthetic lubricating materials through supramolecular dynamic exchange.
View Article and Find Full Text PDFQuant Imaging Med Surg
December 2024
Department of Ultrasound, Huzhou Central Hospital, Huzhou, China.
Background: There are only a few isolated studies that have examined ultrasound-guided magnetic resonance arthrography (USMRA) of the glenohumeral joint and subacromial bursa with the use of gadolinium contrast agent. This study aimed to determine the clinical value of USMRA in the diagnosis of supraspinatus tendon tears and its subtypes.
Methods: Musculoskeletal ultrasound (MSKUS) was performed in 207 patients with shoulder pain as confirmed by arthroscopic examination, 103 of whom underwent shoulder joint magnetic resonance imaging (MRI), and 104 of whom underwent USMRA.
J Chromatogr Sci
December 2024
Experiment Center for Science and Technology, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Chuanxiong Rhizoma (Chuanxiong), a traditional Chinese medicine, has been widely used to treat various nervous and cardiovascular system-related conditions. Its active components, senkyunolide A (SA) and 3-n-butylphthalide (NBP), have been proven effective in treating nervous system diseases. A new method was established based on microdialysis coupled with ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) to estimate the concentrations of these components in brain extracellular fluid.
View Article and Find Full Text PDFJ Pharm Health Care Sci
December 2024
Department of Clinical Pharmacy, School of Medicine, Shanghai General Hospital, Shanghai Jiaotong University, Shanghai, 200080, China.
Background: Oncolytic virus therapy is a rapidly evolving emerging approach for the medical management of cancer. Talimogene laherparepvec (T-VEC) is the first and only Food and Drug Administration (FDA)-approved oncolytic virus therapy. Considering that exactly how T-VEC works is not known, there is a strong need for a comprehensive pharmacovigilance study to identify safety signals of potential risks with T-VEC.
View Article and Find Full Text PDFJ Nanobiotechnology
December 2024
Tongji School of Pharmacy, Huazhong University of Science and Technology, Wuhan, 430030, China.
Sepsis is a severe immune response to pathogens that is associated with high mortality rate and a paucity of efficacious treatment options. It is characterized by the hyperactivation of macrophages and the occurrence of cytokine storms. Given the anti-inflammatory properties of M2 macrophages and their derived apoptotic bodies (AB), as well as the specific uptake of these by macrophages, a novel approach was employed to combine AB with artificial liposomes to create apoptotic body based biomimetic hybrid nanovesicles (L-AB).
View Article and Find Full Text PDFJ Vasc Surg
December 2024
School of Public Health and Preventive Medicine, Monash University, 553 St Kilda Rd, Melbourne, VIC 3004, Australia.
Objective: Whether high-density-lipoprotein cholesterol (HDL-c) has a protective role against abdominal aortic aneurysm (AAA) development in both older males and females remains uncertain. This study aims to assess the sex-specific association between HDL-c and incident AAA in older adults from the UK Biobank.
Methods: This cohort study included 86,184 males and 95,682 females aged ≥60 years from the UK biobank.
Discov Oncol
December 2024
Department of Hematology, Shanghai Ninth People's Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.
Essential thrombocytosis (ET) is a chronic myeloproliferative neoplasm. There is a rare possibility of its transformation from ET into acute myeloid leukemia (AML). While the TP53 mutation is a well-known risk factor for AML, limited research exists regarding ET patients who develop AML with TP53 mutations.
View Article and Find Full Text PDFClinicoecon Outcomes Res
December 2024
Department of Urology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, 200000, People's Republic of China.
Objective: Prostate Cancer can be treated with various formulations of Gonadotropin-Releasing Hormone Agonists (GnRHa), but cost analyses of these treatments in China are lacking. This study aims to evaluate the differences in cost and resource utilization between various formulations of GnRHa for Prostate Cancer by conducting a resource utilization assessment and cost minimization analysis.
Methods: From the perspective of society and medical healthcare, this study used the cost minimization model to generate cost and resource estimates for GnRHa drug acquisition and administration for "Current practice" and for a "Base case" scenario.
Neuropsychiatr Dis Treat
December 2024
Shanghai Mental Health Center, Shanghai Jiaotong University, School of Medicine, Shanghai, People's Republic of China.
N-methyl-D-aspartate receptor encephalitis (NMDARE) presents serious neurological manifestations such as reduced consciousness, seizures, and movement disorders, which can escalate to coma or severe autonomic dysfunction. Treatment typically involves immunotherapy and tumor removal to mitigate the autoimmune response. Timely diagnosis and treatment are critical to prevent severe neurological impairment or death.
View Article and Find Full Text PDFAdv Sci (Weinh)
December 2024
Department of Urology, Affiliated Sixth People's Hospital, Shanghai Jiaotong University School of Medicine, No. 600 Yi-Shan Road, Shanghai, 200233, P. R. China.
The harsh microenvironment of the urethral injury often carries high risks of early undesirable healing as well as late scar tissue formation. Indeed, the infection and inflammatory response in the early stages as well as blood vessel formation and tissue regeneration in the later stages fundamentally impact the outcomes of urethral wound healing. Innovatively, an integrated whole-process repair hydrogel (APF/C/L@dECM) is designed.
View Article and Find Full Text PDFMol Ther Nucleic Acids
December 2024
Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai 200125, China.
Front Pharmacol
December 2024
Department of Clinical Pharmacy, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Neurodegenerative diseases (NDDs) represent a category of serious illnesses characterized by the progressive deterioration of neuronal structure and function. The exploration of natural compounds as potential therapeutic agents has gained increasing attention in recent years owing to their wide range of pharmacological activities and minimal side effects. Baicalin (BAI) and baicalein (BE), polyphenolic flavonoids, derived from the root of , evidently show potential in treating NDDs.
View Article and Find Full Text PDFSchizophr Res Cogn
March 2025
Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai 200030,China.
Background And Objective: The dorsolateral prefrontal cortex (DLPFC) - cerebellum circuit has been implicated in the pathogenesis of negative symptoms of schizophrenia (SZ). Both areas are considered separate targets for repetitive transcranial magnetic stimulation (rTMS) treatment, showing potential for improving negative symptoms. However, there is still a lack of research that targets both DLPFC and cerebellum simultaneously.
View Article and Find Full Text PDFJ Clin Med
December 2024
Department of Otolaryngology-Head & Neck, Audiology and Neurotology, Karolinska University Hospital, 171 76 Stockholm, Sweden.
Hearing loss, affecting over 466 million people worldwide, poses significant challenges for affected individuals, their families, and healthcare providers alike [...
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