Rare earth nanoparticles for sprayed and intravenous NIR II imaging and photodynamic therapy of tongue cancer.

In this research, rare earth nanoparticles coupled with dihydroartemisinin (DHA) and a targeted antibody (RENP-DHA-Cap) for sprayed NIR II imaging and photodynamic therapy (PDT) of tongue cancer were designed. Genetic algorithms combined with combinatorial chemistry were proposed and successfully achieved in a single optimized luminescent phosphor with enhanced NIR II and high upconversion luminescence (UCL) under a NIR laser of wavelength 980 nm or/and 808 nm. In particular, T1 magnetic resonance imaging (MRI) signals can be adjusted with the Gd ion concentration.

BMP-2/CPC scaffold with dexamethasone-loaded blood clot embedment accelerates clinical bone regeneration.

Delayed repair caused by prolonged inflammatory response might lead to clinical nonunion and failed bone regeneration. The design of desirable biomaterials requires precise regulation of the initial osteoimmune responses and efficient osteoinductive capacity to facilitate later bone regeneration. Herein, a Dex-loaded blood clot-embedded BMP-2/CPC scaffold (Dex/blood/BMP-2/CPC) was fabricated for clinical bone regeneration with the sequential release of dexamethasone (Dex), a clinical immunosuppression drug, and BMP-2, a potent osteogenic growth factor.

Protective effect of COMP-angiopoietin-1 on peritoneal vascular permeability and peritoneal transport function in uremic peritoneal dialysis rats.

The angiopoietin-1 (Ang-1)/Tie-2 signaling pathway plays a crucial role in the maintenance of vascular stabilization and permeability. In this study, we evaluated the protective effect of a designed Ang-1 variant (COMP-Ang-1) on peritoneal vascular permeability and peritoneal transport function in a uremic peritoneal dialysis (PD) model. Compared to the sham controls, uremic rats were characterized by decreased pericyte coverage and downregulated endothelial junction expression.

Comparison of various reagents for preparing a decellularized porcine cartilage scaffold.

Cartilage lesion repair is difficult due to the limited self-repair capability of cartilage and its lack of vascularization. Our previous study established a sandwich model for engineering cartilage with acellular cartilage sheets (ACSs) and chondrocytes. However, there is still debate over which agent achieves the optimal decellularization of cartilage sheets.

Control-released Alpha-lipoic acid-loaded PLGA microspheres enhance bone formation in type 2 diabetic rat model.

Since diabetes lead to alterations in bone metabolism with reductions in bone mineral content and delayed bone formation, the most effective method for bone regeneration in diabetes remains to be determined. In this study, type 2 diabetes were successfully induced via a high-fat diet and low-dose streptozotocin intraperitoneal injection. Excess reactive oxygen species (ROS) has been implicated in diabetes mellitus.

Fabrication and clinical application of easy-to-operate pre-cured CPC/rhBMP-2 micro-scaffolds for bone regeneration.

Bone tissue engineering scaffolds loading growth factors have been considered as the most perspective among all bone substitutes, yet little progress of its clinical translation has been made. The concept of "micro-scaffolds" was proposed in this study to provide a trajectory to the clinical translation of porous scaffolds. Combining CPC and rhBMP-2, a pre-cured CPC/rhBMP-2 micro-scaffold has been successfully developed and further applied as an easy-to-operate filler for bone regeneration in a pilot clinical study.

[Evaluation of flipped classroom teaching model in undergraduates education of oral and maxillofacial surgery].

Flipped classroom is a new teaching model which is different from the traditional teaching method. The history and characteristics of flipped classroom teaching model were introduced in this paper. A discussion on how to establish flipped classroom teaching protocol in oral and maxillofacial surgery education was carried out.

Long non-coding RNA HOTTIP is up-regulated and associated with poor prognosis in patients with osteosarcoma.

Long non-coding RNAs (lncRNAs) have been shown to play key roles in cancer development and progression. In this study, we focused on lncRNA HOTTIP and investigated its expression pattern, clinical significance, and biological function in osteosarcoma (OS). In the present study, lncRNA HOTTIP expression in OS tissues was examined and its correlation with clinicopathological features and patient prognosis was analyzed.

HAX-1 is overexpressed in hepatocellular carcinoma and promotes cell proliferation.

Hepatocellular carcinoma (HCC) is the most common primary liver tumor. Due to the asymptomatic nature of early HCC and lack of effective screening strategies, 80% of patients present with advanced HCC at the time of diagnosis. Novel molecular marker identification will be valuable for effective diagnosis and treatment.

Guidelines for the treatment of head and neck venous malformations.

Venous malformation is one of the most common benign vascular lesions, with approximately 40% of cases appearing in the head and neck. They can affect a patient's appearance and functionality and even cause life-threatening bleeding or respiratory tract obstruction. The current methods of treatment include surgery, laser therapy, sclerotherapy, or a combined.

[Efficacy and safety of 3% mepivacaine hydrochloride injection for oral local anesthesia].

Purpose: To assess the efficacy and safety of 3% mepivacaine hydrochloride injection for oral local anesthesia.

Methods: 68 non-hypertension patients and 36 hypertension patients were randomly divided into 2 groups for local anesthesia. 2% lidocaine with adrenaline in same cartridge was as control group and 3% mepivacaine was as the experimental group.

[Application of comparative proteomics in oral squamous cell carcinoma].

Comparative proteomics is to compare the differential expression of overall protein profiles in different time and space, to identify differential proteins or protein groups on the expression amount, expression level, and modification status, and to further investigate the differential proteins and their function. The aim of this paper is to introduce the application of comparative proteomics in oral squamous cell carcinoma on the level of cell, tissue, and body fluid. Supported by National Natural Science Foundation of China (Grant No.

[Color distribution of the anterior teeth in 137 elder people].

Purpose: To study the color distribution of the anterior teeth in elder people.

Methods: 612 anterior teeth from 137 people aging from 60 to 81 years and 200 anterior teeth from 100 young people aging from 20 to 40 years were collected. A digital colorimeter was used to measure the value of L*,a*,b* of the teeth, and the chromatism (deltaE) was calculated according to the formula deltaE=(deltaL*(2)+deltaa*(2)+deltab*(2))1/2.

[The effect of tooth preparation design on the CEREC all-ceramic crown's marginal adaptation].

Purpose: To study the effect of tooth preparation on marginal adaptation of all-ceramic crown designed by the Cerec system.

Methods: Lower first molar in the standard model was prepared into four types, two occlusal convergences (6 degrees and 12 degrees ) and two marginal shapes (chamfer and shoulder), and then divided into four groups correspondingly with 8 copies of abutment preparation test piece in each group. All-ceramic crown was designed by the Cerec 3 system and inserted with corresponding test piece.

[7-year clinical application of Straumann implants].

Purpose: To evaluate 7-year clinical application of Straumann implant treatment.

Methods: 5532 non-submerged Straumann implants were placed from july 2000 to december 2006 at the department of implantology, Ninth People's Hospital, College of Stomatology, School of Medicine, Shanghai Jiao Tong University. The average age of 2449 patients was 40.

[A preliminary study of combined periodontal-orthodontic approach for treating labial displacement of incisors in patients with periodontal diseases].

Purpose: The purpose of this study was to evaluate the effect of combined periodontal-orthodontic treatment for patients who had chronic periodontitis with labial displacement of incisors and radiological evidence on migrated incisors.

Methods: Twenty-one adult patients were included in the study. Fifty-two migrated incisors were randomly assigned to treatment with circumferential supracrestal fibrotomy or non-surgery.

[Biomechanical evaluation of zygomatic implant in unilateral maxillary defect restoration].

Purpose: To establish a standardized and modularized finite element model of a normal human skull to simulate the unilateral defect pattern of the maxilla and the stress distribution of craniofacial skeleton with repair subject to the bite force, and to make biomechanical evaluation and functional design of the unilateral maxillary reconstruction method using the microsurgery bone graft and zygomatic implant.

Methods: Based on CT scan and image process technology, a modularized geometrical and finite element model of the human skull was built to simulate unilateral defect pattern of the maxilla and design of the position, direction, length of the zygoma fixture, and the number of the conventional fixtures. Biomechanical properties of the design were evaluated using finite element analysis (FEA) method.

[Arch perimeter changes on non-extraction correction of dental crowding with Damon appliance].

Purpose: To clarify the arch perimeter changes and the mechanism of Damon technique on the correction of dental crowding with non-extraction approach in different dental stages.

Methods: 24 patients with non-extraction Damon appliance treatment were reviewed. They had Class I skeletal pattern and upper arch crowding more than 5mm.

[A comparison of rapid palatal expansion and Damon appliance on non-extraction correction of dental crowding].

Purpose: To compare the effect of rapid palatal expansion (RPE) and Damon technique on the correction of dental crowding with non-extraction approach.

Methods: 19 adolescent patients with non-extraction orthodontic treatment were reviewed. They had Class I skeletal pattern and moderate crowding.

Use of allogenic acellular dermal matrix in prevention of Frey's syndrome after parotidectomy.

Objective: To evaluate the use of an allogenic acellular dermal matrix (ADM) as an interpositional graft to prevent Frey's syndrome after parotidectomy.

Method: We studied a total of 168 patients with benign parotid gland tumours, including 89 patients with pleomorphic adenoma; 45 with Warthin tumour; 17 with basal cell adenoma; and 17 with miscellaneous tumours. The patients were divided into two groups: the first (control n=104) had superficial or partial parotidectomy alone, and the second (experimental n=64), had superficial or partial parotidectomy with simultaneous placement of an ADM graft.

[Imaging diagnosis of myoepithelioma of the salivary glands].

Purpose: To investigate CT imaging and clinical features of myoepithelioma (ME) of the salivary glands.

Methods: The imaging manifestations of 17 patients from 2003 to 2007 were retrospectively analyzed. The age of the 17 patients ranged from 23 years to 70 years (mean age: 46 years).

[Changes of GABA(A) receptor in medulla of injury of trigeminal nerve in rats].

Purpose: To assess the relationship between GABAA receptor in rats's medulla and injury of rats's trigeminal nerve by using real-time polymerase chain reaction(PCR).

Methods: Twenty SD rats were divided into four groups randomly, five rats in each group. Group A and group C were surgical groups, Group B and group D were sham surgical groups.