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Quercetin-Loaded Zeolitic Imidazolate Framework-8 (ZIF-8) Nanoparticles Attenuate Osteoarthritis by Activating Autophagy via the Pi3k/Akt Signaling.
ACS Appl Mater Interfaces
August 2024
Department of Radiology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine Institution, Shanghai 200100, China.
Osteoarthritis treatment remains a significant clinical challenge. Quercetin, a natural flavonoid with anti-inflammatory and antiapoptotic properties, might be utilized to treat OA. However, poor water solubility and short joint retention duration limit its bioavailability and translation to clinical applications.
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