5 results match your criteria: "Shanghai Jiao Tong University School of Medicine 639 Zhizaoju Road[Affiliation]"
The enhanced osteogenesis and osteointegration of 3-DP PCL scaffolds structural and functional optimization using collagen networks.
RSC Adv
September 2018
Shanghai Key Laboratory of Tissue Engineering, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine 639 Zhizaoju Road Shanghai 200011 PR China +86-21-34291002.
Optimal balance between biological activity and mechanical stability should be meticulously considered during scaffold design for bone tissue engineering applications. To fabricate an individualized construct with biomechanical and biological functionality for bone tissue regeneration, a polycaprolactone-collagen (PCL-COL) composite construct was developed through the combination of three-dimensional printing (3-DP) technology and biomimetic collagen matrix incorporation, with a 3-DP PCL framework maintaining the mechanical stability and a porous collagen matrix improving the biological activity. The results indicate that the compressive modulus of the composite constructs increased synergistically (over 40 MPa), providing sufficient mechanical support during new bone formation.
View Article and Find Full Text PDFA novel application of electrospun silk fibroin/poly(l-lactic acid--ε-caprolactone) scaffolds for conjunctiva reconstruction.
RSC Adv
May 2018
Department of Ophthalmology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine 639 Zhizaoju Road Shanghai 200011 China +86 021 6313 7148 +86 021 6313 5606.
Article Synopsis
- The study explores the development of electrospun hybrid nanofibers made from silk fibroin (SF) and poly(l-lactic acid--ε-caprolactone) (PLCL) for tissue engineering applications.
- Scanning electron microscopy (SEM) confirmed that the SF/PLCL scaffolds had a smooth surface and were hydrophilic, which is beneficial for cell adhesion.
- Rabbit conjunctival epithelial cells cultured on these scaffolds showed good proliferation and gene expression, indicating strong potential for use in conjunctival reconstruction surgeries.
3D Printing of Lotus Root-Like Biomimetic Materials for Cell Delivery and Tissue Regeneration.
Adv Sci (Weinh)
December 2017
Biomimetic materials have drawn more and more attention in recent years. Regeneration of large bone defects is still a major clinical challenge. In addition, vascularization plays an important role in the process of large bone regeneration and microchannel structure can induce endothelial cells to form rudimentary vasculature.
View Article and Find Full Text PDFPiperine mediates LPS induced inflammatory and catabolic effects in rat intervertebral disc.
Int J Clin Exp Pathol
May 2016
Shanghai Key Laboratory of Orthopaedic Implants, Department of Orthopaedics, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine 639 Zhizaoju Road, Shanghai 200011, China.
Piperine is an exact of the active phenolic component from Black pepper. It has been reported to have many biological activities including anti-oxidant, anti-inflammatory and anti-tumor effects. Intervertebral disc degeneration (IDD) is a degenerative disease closely relate to inflammation of nucleus pulposus (NP) cells.
View Article and Find Full Text PDFUp-regulation of VEGF and its receptor in refractory leukemia cells.
Int J Clin Exp Pathol
April 2016
Department of Hematology, Tongji Hospital of Tongji University 389 Xincun Road, Shanghai 200065, China.
Objective: To analyze the causative mechanisms in refractory leukemia cells.
Methods: Vascular endothelial growth factor (VEGF) blood plasma concentrations in 35 de novo, 6 relapse, 20 remission leukemia patients and 10 healthy kids were determined via ELISA analyses. Transcription levels of the VEGF receptors (VEGFR) Fms-like tyrosine kinase-1 (Flt-1) and kinase-domain insert containing receptor (KDR) were determined in participants' leucocytes with RT-PCR.