815 results match your criteria: "Shanghai Changhai Hospital[Affiliation]"

Cycled light in the intensive care unit for preterm and low birth weight infants.

Cochrane Database Syst Rev

December 2024

Paediatrics, Department of Clinical Sciences Lund, Lund University, Skåne University Hospital, Lund, Sweden, Lund, Sweden.

Background: Preterm and low birth weight infants are at an early stage of development, and do not receive adequate maternal circadian signals. They are often cared for over prolonged periods of hospitalisation in neonatal intensive care units (NICU), where environmental circadian stimuli are lacking. Exposure to artificial light-dark cycles may stimulate the development of the circadian system and improve clinical outcomes.

View Article and Find Full Text PDF

Background: Differences between virtual bronchoscopic navigation (VBN) systems and their impacts on the diagnostic yield of transbronchial biopsy (TBB) of peripheral pulmonary nodules (PPNs) remain unclear.

Objectives: To compare the Synapse 3D system (Version 4.4, Fujifilm, Japan) and DirectPath system (Version 2.

View Article and Find Full Text PDF

Mussel-inspired multi-bioactive microsphere scaffolds for bone defect photothermal therapy.

Mater Today Bio

December 2024

Department of Orthopedics, Shanghai Changhai Hospital, Naval Medical University, Shanghai, 200433, China.

Hydrogel microspheres hold great promise as scaffolds for bone repair. Their hydrated matrix, biocompatibility, and functional properties make them an attractive choice in regenerative medicine. However, the irregularity of defect requires shape adaptability of the microspheres.

View Article and Find Full Text PDF

Human epidermal growth factor receptor-2 (HER2) negative advanced gastric cancer (GC) has a high global incidence and mortality rate with limited options for second-line treatment. Monotherapy is not effective and the combination of chemotherapy and immunotherapy has not yet been included in the guidelines. The present study aimed to explore a new treatment approach by conducting a single-center, retrospective, observational real-world study.

View Article and Find Full Text PDF

Background: Angiotensin-converting enzyme-2 (ACE2) acts as a key regulatory molecule and important therapeutic target in the pathological remodeling of numerous organs and diseases. In this study, a rapid, simple, and efficient synthetic route with a catalytic, F-for-Cl (F/Cl) exchange scheme was designed for the preparation of F-labeled MLN-4760, and its targeting ability was investigated in a humanized ACE2 mouse model.

Results: A novel F-labeled MLN-4760 radioligand, abbreviated as F-MLN-4760, was successfully synthesized by the F/Cl exchange-labeling, and was purified by SepPak C18 columns with a radiochemical yield of 30% and a radiochemical purity of 29.

View Article and Find Full Text PDF

Aims: To develop a novel nanomicelle system to target and eradicate CD133-expressing lung cancer stem cells (CSCs) while imaging lung cancer.

Methods: Averatinib nanomicelles with CD133 aptamers incorporated with gadolinium imaging reagents (M-Afa&Gd-CD133) were synthesized. The anticancer and imaging activities of M-Afa&Gd-CD133 were evaluated both in vitro and in vivo.

View Article and Find Full Text PDF

Background: Currently, the applicant has chosen a target plasma trough concentration for nirmatrelvir, which is adjusted to 292 ng/mL based on the drug's molecular weight (499.54 Daltons), its binding to human plasma proteins (69%), and the in vitro antiviral EC value (181 nM). However, the current exposure-effect relationships (ER) analysis of viral load in patients enrolled in the EPIC-HR study has not revealed clinically significant trends in the ER.

View Article and Find Full Text PDF

A transcriptome data set for comparing skin, muscle and dorsal root ganglion between acute and chronic postsurgical pain rats.

Sci Data

November 2024

Department of Anesthesiology, Shanghai Eastern Hepatobiliary Surgery Hospital, Naval Medical University, Shanghai, 200438, China.

Chronic postsurgical pain (CPSP), with a high prevalence and rising epidemic of opioids crisis, is typically derived from acute postoperative pain. Our knowledge on the forming of chronic pain mostly derives from mechanistic studies of pain processing in the brain and spinal cord circuits, yet most pharmacological interventions targeting CNS came to be unhelpful in preventing CPSP. Revealing the peripheral mechanisms behind the transition from acute to chronic pain after surgery could shine a light on the novel analgesic regimens.

View Article and Find Full Text PDF

Targeted Sonodynamic Therapy Platform for Holistic Integrative Helicobacter pylori Therapy.

Adv Sci (Weinh)

November 2024

Department of Gastroenterology, Shanghai Institute of Pancreatic Diseases, Changhai Hospital, Shanghai, 200433, China.

Helicobacter pylori (H. pylori) is a primary pathogen associated with gastrointestinal diseases, including gastric cancer. The increase in resistance to antibiotics, along with the adverse effects caused by complicated medication protocols, has made the eradication of H.

View Article and Find Full Text PDF

Hematologic adverse events (AEs) are common and serious toxicities in patients with hematologic malignancies undergoing blinatumomab therapy. However, restrictive selection criteria in pivotal clinical trials can lead to an underestimation of rare but fatal toxicities. In this study, we systematically analyzed hematologic AEs associated with blinatumomab using the Food and Drug Administration Adverse Event Reporting System (FAERS) from October 2014 to December 2023.

View Article and Find Full Text PDF

Cas14VIDet: A visual instant method free from PAM restriction for antibiotic resistance bacteria detection.

Biosens Bioelectron

January 2025

Department of Gastroenterology, Ganzhou People's Hospital Affiliated to Nanchang University, Ganzhou, 341000, China; Department of Gastroenterology, Shanghai Changhai Hospital, Naval Medical University, Shanghai, 200433, China. Electronic address:

A personalized treatment strategy that selects sensitive antibiotics based on Helicobacter pylori (H. pylori) resistance genes is currently the most effective approach to address the challenge of H. pylori eradication.

View Article and Find Full Text PDF

[ gene is highly expressed in colorectal cancer: its prognostic implications and potential as a therapeutic target].

Nan Fang Yi Ke Da Xue Xue Bao

September 2024

Department of Colorectal Surgery, Shanghai Changhai Hospital, Naval Medical University, Shanghai 200082, China.

Objective: To investigate the expression level of HNRNP A1 in colorectal cancer (CRC) and its prognostic implications.

Methods: We investigated HNRNP A1 expression level in CRC using HPA, TIMER, and GEPIA databases and analyzed its association with Ki-67 and VEGFA expressions. Kaplan-Meier Plotter database was used to analyze the correlation of HNRNP A1 mRNA levels with the survival rates of CRC patients.

View Article and Find Full Text PDF

A deep learning algorithm that aids visualization of femoral neck fractures and improves physician training.

Injury

December 2024

Department of Radiology, The 989th Hospital of the PLA Joint Logistics Support Force, Luoyang, Henan Province, China; Department of Radiology, General hospital of Central Theater Command, Wuhan, Hubei Province, China. Electronic address:

Article Synopsis
  • * Using 1,527 radiographs, the model achieved a high accuracy rate of 94.1% in detecting fractures, and significantly improved the diagnostic accuracy of emergency physicians and training outcomes for medical trainees.
  • * The findings suggest that integrating deep learning algorithms into clinical practice can enhance physicians' ability to visualize fractures and improve their training effectiveness.
View Article and Find Full Text PDF

Alzheimer's disease (AD) is a neurological disorder leading to cognitive deficits. Salidroside (Sal), a primary bioactive ingredient extracted from the roots of Rhodiola rosea L., has potent neuroprotective effects in AD.

View Article and Find Full Text PDF

Similarities and differences between chronic primary pain and depression in brain activities: Evidence from resting-state microstates and auditory Oddball task.

Behav Brain Res

February 2025

Department of Neurology, Shanghai Changhai Hospital, 168 Changhai Road, Shanghai 200433,  China; Shanghai United Family Hospital, 699 Pingtang Road, Changning District, Shanghai 200335, China. Electronic address:

Article Synopsis
  • The concept of chronic primary pain (CPP) was introduced in 2019 to describe persistent pain without clear physical causes, often associated with emotional issues like depression.
  • This study used EEG recordings to compare brain activity between healthy individuals, depressed patients, and those with CPP, identifying specific brain patterns related to each group.
  • Results showed that both CPP and major depressive disorder share certain brain abnormalities, but CPP's changes in brain network dynamics differ from those seen in depression, suggesting unique underlying mechanisms and potential for future biomarker development.
View Article and Find Full Text PDF
Article Synopsis
  • - Over the last 30 years, miniaturized percutaneous nephrolithotomy (mPCNL) has gained popularity due to its potential to reduce complications compared to standard procedures, but there's still debate over best practices and management strategies that hinders wider use.
  • - An international panel of urology experts developed a consensus document on mPCNL to provide a comprehensive framework for practice, which included reviewing literature, identifying research gaps, and conducting surveys to gather expert opinions.
  • - The study revealed 58 key questions on mPCNL practices, and consensus was achieved on 30 questions, affirming mPCNL as an effective technique for treating upper urinary tract stones in both adults and children.
View Article and Find Full Text PDF

The standard treatment for osteosarcoma combines surgery with chemotherapy, yet it is fraught with challenges such as postoperative tumor recurrence and chemotherapy-induced side effects. Additionally, bone defects after surgery often surpass the body's regenerative ability, affecting patient recovery. Bioengineering offers a novel approach through the use of bioactive scaffolds crafted from metals, ceramics, and hydrogels for bone defect repair.

View Article and Find Full Text PDF
Article Synopsis
  • * A case study highlights a patient with rectal invasion by prostate cancer, who underwent total pelvic exenteration (TPE) and was found to have a high tumor mutation burden; the patient subsequently received combined androgen deprivation therapy (ADT) and immunotherapy.
  • * After six years, the patient showed no signs of recurrence, suggesting that TPE coupled with immunotherapy could enhance survival prospects in similar cases, emphasizing the need for accurate diagnosis through interdisciplinary collaboration and advanced testing.
View Article and Find Full Text PDF

Background: Although the therapeutic effects of berberine have received some attention in recent years, its potential mechanisms underlying its action against stomach carcinoma (SC) remain unclear. In this study, we aimed to elucidate the mechanisms underlying the effects of berberine against SC using a network pharmacology and experimental verification approach.

Methods: Several publicly available databases were used to collect the targets of berberine and SC.

View Article and Find Full Text PDF