Enhance Anti-obesity Effect of Natural Compounds through Carrier Mediation.

Obesity is a global public health problem that can lead to many health complications or comorbidities. Medication alone or in combination with lifestyle changes or surgery is the main way to combat obesity and its complications. Most anti-obesity drugs are limited by their bioavailability, target-specific, and potentially toxic effects, so there is an urgent need for alternative treatments.

Achieving China's CO reduction targets: Insights from a hybrid PPA-PPR forecasting model.

China is the largest carbon dioxide (CO) emitter and has formulated CO emission peak and carbon-neutral plans. Studies on CO emission volume and CO emission intensity (CEI) indicate a growing interest in related fields. The purpose of this research is to improve the performance and reliability of the model for forecasting CO emissions and judging whether to achieve China's CO reduction targets under business-as-usual scenarios.

Exercise combined with vitamin D supplementation has additive health effects on short physical performance battery and stair climbing in older adults: a scope review of randomised controlled trials.

This scoping review aimed to evaluate the effect of exercise combined with vitamin D supplementation on skeletal muscle health in older individuals. We implemented a systematic search of electronic databases, including PubMed, the Cochrane Library, Web of Science and Embase, which was conducted from the time of library construction to January 2024. Eligible studies were randomised controlled trials including men and women aged ≥ 65 years or mean age ≥ 65 years; exercise training and vitamin D supplementation; outcomes of muscular strength, function, muscular power, body composition and quality of life; and results compared with those of exercise intervention alone.

Next-generation photodynamic antimicrobial materials made by direct synthesis of functional bacterial cellulose.

Bacterial cellulose (BC) regularly uses chemical or physical modifications to produce antimicrobial wound dressings. However, there is a risk of loss of functional components during application. Moreover, a significant hurdle lies in successfully integrating durable and highly effective bactericidal entities with BC.

LRa05 mediates dynamic regulation of intestinal microbiota in mice with low-dose DSS-induced chronic mild inflammation.

Aim: This study aimed to investigate the effects of low-dose dextran sulfate sodium (DSS) on the induction of chronic mild inflammation in mice and to evaluate the therapeutic potential of LRa05 (LRa05) to ameliorate the associated effects. The focus was on investigating changes in inflammatory, gut microbiota, serum lipopolysaccharide (LPS) and inflammatory cytokines.

Methods: Mice were exposed to a low-dose of DSS to induce chronic mild inflammation and LRa05 was administered as a probiotic intervention.

Inter-Mode Crosstalk Estimation between Cores for Modes in Weakly Coupled Few-Mode Multicore Fiber with Perturbations.

A novel inter-mode crosstalk (IMXT) model of LPmn mode for weakly coupled few-mode multicore fiber is proposed based on the coupled mode theory (CMT) with bending and twisting perturbations. A universal expression of the mode coupling coefficient (MCC) between LPmn modes is derived. By employing this MCC, the universal semi-analytical model (USAM) of inter-core crosstalk (ICXT) can be applied to calculate the IMXT.

Can low-carbon city pilot policy boost tourism development? Empirical evidence from China.

As an environmental regulatory tool in achieving green development, the low-carbon city pilot policy (LCCP) considerably influence tourism enhancement. Using China's 261 prefecture-level cities, this paper empirically delve the implication of LCCP to tourism from two tourism dimensions of tourism revenue and tourism arrivals employing the time-varying DID methodology. Results empirically reveal that the LCCP contributes to boosting tourism development, and after undergoing numerous robustness tests, this finding stands.

Efficacy of rehabilitation physiotherapy combined with brace correction in patients with mild to moderate scoliosis secondary to cerebral palsy.

Background: Scoliosis secondary to cerebral palsy is one of the common complications of cerebral palsy in children with cerebral palsy.

Objective: This study aimed to explore the efficacy of rehabilitation combined with brace correction in patients with scoliosis secondary to cerebral palsy.

Methods: A total of 52 patients with scoliosis secondary to cerebral palsy were selected from our hospital from April 2019 to April 2022 and divided into the control group and experimental group according to the statistical randomization method (n= 26 in each group).

Advancing Chinese biomedical text mining with community challenges.

Objective: This study aims to review the recent advances in community challenges for biomedical text mining in China.

Methods: We collected information of evaluation tasks released in community challenges of biomedical text mining, including task description, dataset description, data source, task type and related links. A systematic summary and comparative analysis were conducted on various biomedical natural language processing tasks, such as named entity recognition, entity normalization, attribute extraction, relation extraction, event extraction, text classification, text similarity, knowledge graph construction, question answering, text generation, and large language model evaluation.

Organophosphate esters in human serum: a relatively simple and efficient liquid chromatography-mass spectrometry method.

Organophosphate esters (OPEs) are widely used as flame retardants and plasticizers, which are of growing concern due to their endocrine-disrupting effects, developmental toxicity, and potential carcinogenicity. However, data on human exposure to OPEs is still scarce. In this study, a relatively simple and efficient method with less serum consumption for the detection of OPEs in human serum was developed and validated.

LC86 mitigates age-related muscle wasting and cognitive impairment in SAMP8 mice through gut microbiota modulation and the regulation of serum inflammatory factors.

Purpose: Chronic inflammation contributes to the decline in muscle strength and cognitive abilities associated with aging. This study aims to clarify the effects of oral administration of LC86 on these age-related declines, as well as its impact on the composition of gut microbiota.

Methods: Senescence-accelerated mouse prone 8 (SAMP8) mice received a 12 week regimen of LC86 (1 × 10 CFU/day).

Reduction in Serum Concentrations of Uremic Toxins Driven by Bifidobacterium Longum Subsp. Longum BL21 is Associated with Gut Microbiota Changes in a Rat Model of Chronic Kidney Disease.

Gut microbiota dysbiosis and consequent impairment of gut barrier function, culminating in elevated levels of uremic toxins, are prevalent in chronic kidney disease (CKD) patients. These toxins, notably indoxyl sulphate (IS), indole-3-acetic acid (IAA), and trimethylamine oxide (TMAO), are implicated in a spectrum of CKD-related complications, including cardiovascular disease, bone and mineral disorders, and inflammation. The specific impacts of various probiotics on these CKD manifestations remain unexplored.

Regulation of gut microbiota and serum neurotransmitters in mice by Streptococcus thermophilus GA8- and Lacticaseibacillus rhamnosus HAO9-fermented milk containing high levels of gamma-aminobutyric acid.

Background: Gamma-aminobutyric acid (GABA) is an important neurotransmitter in the human body, with several negative emotions reported as being associated with GABA dysregulation. This study investigates the safety and modulatory effects of GABA-enriched milk, fermented by Streptococcus thermophilus GA8 and Lacticasebacillus rhamnosus HAO9, on the gut microbiota and neurotransmitter profiles in mice.

Results: Through rigorous culturing and fermentation processes, we achieved consistent GABA production in milk, with concentrations reaching 4.

Bayesian analysis of physiologically based toxicokinetic (PBTK) modeling for pentachlorophenol exposure in pregnant women.

Pentachlorophenol (PCP) is a persistent organic compound that is widely present in the environment. The estimation of internal exposure levels for a given external exposure using toxicokinetic models is key to the human health risk assessment of PCP. The present study developed a physiologically based multicompartmental pharmacokinetic (PBTK) model to describe and predict the behavior of pentachlorophenol (PCP) in an organism.

Information consumption city and carbon emission efficiency: Evidence from China's quasi-natural experiment.

The transformation of public consumption patterns has become a burning question, but there are few studies on public consumption patterns. Therefore, evaluating the impact of Information consumption city (ICC) policy on carbon emission efficiency holds significant implications. This study settles on 104 pilot cities in China from 2006 to 2020 to assess the impact and the response mechanism of ICC policy on carbon emission efficiency through the time-vary Difference-in-Difference (DID) model.

The effect of collectivism-oriented human resource management on employee resilience of hospitality employees.

Introduction: In the face of an increasingly challenging and rapidly evolving business environment, not all the employees exhibit the requisite resilience necessary to recover from adversity. From both the individual and organizational perspectives, enhancing employee resilience emerges as a critical issue not only in the practical and academic fields. In the Chinese culture, this research aims to investigate how and why collectivism-oriented human resource management (C-HRM) fosters employee resilience.

Healthier Dietary Patterns Are Associated with Better Sleep Quality among Shanghai Suburban Adults: A Cross-Sectional Study.

Background: More is to be explored between dietary patterns and sleep quality in the Chinese adult population.

Methods: A cross-sectional study including 7987 Shanghai suburban adults aged 20-74 years was conducted. Dietary information was obtained using a validated food frequency questionnaire.

Analysis of spatial characteristics and influencing factors of the flow network of highly educated talents from national and local perspective.

Based on dynamic monitoring data on China's population, by using complex networks, spatial analysis and mathematical measurement, this study reveals the spatial characteristics and influencing factors of the network of flows of highly educated talents in the Yangtze River Delta region from the national and local perspectives. In the two perspectives, the network has strong isomorphism and certain differences. The in-flow of highly educated talents from cities with high administrative levels and more developed economies to Shanghai constitutes the core of the entire network.

The NAC056 transcription factor confers freezing tolerance by positively regulating expression of CBFs and NIA1 in Arabidopsis.

Freezing stress can seriously affect plant growth and development, but the mechanisms of these effects and plant responses to freezing stress require further exploration. Here, we identified a NAM, ATAF1/2, and CUC2 (NAC)-family transcription factor (TF), NAC056, that can promote freezing tolerance in Arabidopsis. NAC056 mRNA levels are strongly induced by freezing stress in roots, and the nac056 mutant exhibits compromised freezing tolerance.

The dual impacts of guanxi closeness on followership: Mediating roles of burnout and power distance.

Guanxi and followership play important roles in employees' interaction with their supervisors. Extant studies have found that supervisor-subordinate guanxi can predict subordinates' attitudes and behaviors toward their supervisors. However, little is known about the relationship between guanxi closeness and subordinates' following supervisors.

[Deep Learning-Based Key Frame Recognition Algorithm for Adrenal Vascular in X-Ray Imaging].

Adrenal vein sampling is required for the staging diagnosis of primary aldosteronism, and the frames in which the adrenal veins are presented are called key frames. Currently, the selection of key frames relies on the doctor's visual judgement which is time-consuming and laborious. This study proposes a key frame recognition algorithm based on deep learning.

Evaluating the metropolitan public health preparedness for pandemics using entropy-TOPSIS-IF.

Introduction: Metropolitan governance's efficacy is regularly gauged by its capability for public health preparedness, a critical component, particularly in the post-pandemic climate, as global cities reassess their mitigation abilities. This process has broader implications, curbing mortality rates and amplifying sustainability. Current methodologies for preparedness assessment lean primarily on either Subjective Evaluation-Based Assessment (SBA), predicated on experts' input on various capacity indicators, or they opt for Data-Based quantitative Assessments (DBA), chiefly utilizing public statistic data.

The power of attention: Government climate-risk attention and agricultural-land carbon emissions.

Climate change is a common challenge faced by all humanity. Promoting emission and carbon reduction in agricultural land is the most important priority for addressing climate change and realizing sustainable development. Based on data from 296 prefecture-level cities in China from 2011 to 2021, this study utilizes machine-learning and text-analysis methods to construct an indicator of government climate-risk attention (GCRA).