287 results match your criteria: "Shands HealthCare & University of Florida[Affiliation]"
Hosp Pract (1995)
October 2016
h Market Access, GfK Custom Research LLC , Wayland , MA , USA.
This article was written with the aim to establish a consensus clinical pathway for long-acting lipoglycopeptide antibiotics such as oritavancin (Orbactiv®) and dalbavancin (Dalvance®) for the treatment of acute bacterial skin and skin structure infections (ABSSSI). Seven infectious diseases pharmacy specialists from a variety of facilities across the United States (US) participated in a roundtable discussion to consider the use of newer single-dose long-acting lipoglycopeptides, and integrate them into clinical pathways for ABSSSI. They identified two ways of treating with these drugs: first, to facilitate discharge from the hospital by switching from initial therapy (e.
View Article and Find Full Text PDFIntensive Care Med
September 2016
Department of Pharmacotherapy and Translational Research, University of Florida College of Pharmacy, 1225 Center Drive, HPNP Bldg., Room 3315, PO Box 100486, Gainesville, FL, 32610-0486, USA.
Mol Genet Metab
June 2016
Division of Genetics and Genomics, Boston Children's Hospital, 300 Longwood Ave, Boston, MA 02115, USA. Electronic address:
Background: In 2014, recommendations for the nutrition management of phenylalanine hydroxylase deficiency were published as a companion to the concurrently published American College of Medical Genetics and Genomics guideline for the medical treatment of phenylketonuria (PKU). These were developed primarily from a summary of findings from the PKU scientific review conference sponsored by the National Institutes of Health and Agency for Healthcare Research & Quality along with additional systematic literature review. Since that time, the Genetic Metabolic Dietitians International and the Southeast Regional Newborn Screening and Genetics Collaborative have partnered to create a web-based technology platform for the update and development of nutrition management guidelines for inherited metabolic disorders.
View Article and Find Full Text PDFRadiol Clin North Am
May 2016
Division of Abdominal Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, White 270, Boston, MA 02114, USA.
MEN1, MEN2, and MEN4 comprise a series of familial disorders involving the simultaneous occurrence of tumors in more than one endocrine organ, collectively known as multiple endocrine neoplasia. Patients with this family of disorders develop tumors of the parathyroid gland, pancreas, pituitary gland, adrenal gland, and thyroid gland, along with miscellaneous neuroendocrine tumors of the respiratory and gastrointestinal tracts. Although some patients undergo early prophylactic surgical management, particularly in the setting of familial medullary thyroid carcinoma, many develop tumors later in life.
View Article and Find Full Text PDFSemin Vasc Surg
June 2015
Department of Surgery, Division of Vascular Surgery and Endovascular Therapy, University of Florida College of Medicine, Shands Hospital, 1600 SW Archer Road, Gainesville, FL 32603. Electronic address:
The Society for Vascular Surgery Vascular Quality Initiative (VQI) is a collaborative network of vascular specialists from various specialties that seeks to improve the quality and safety of vascular care by sharing data among physicians, medical centers, and regions. Working under a Patient Safety Organization designation by the Agency for Healthcare Research and Quality, the VQI provides a protected environment where data can be pooled and evaluated for trends that might provide opportunities to improve the care we provide our patients. Since its inception in 2011, this national organization has grown rapidly and now involves >300 medical centers that are separated into 18 active regional groups who meet twice yearly to discuss quality improvement.
View Article and Find Full Text PDFSurgery
February 2016
Department of Surgery, University of Florida College of Medicine, Gainesville, FL. Electronic address:
'Big data' is the next frontier of medicine. We now have the ability to generate and analyze large quantities of healthcare data. Although interpreting and integrating this information into clinical practice poses many challenges, the potential benefits of personalized medicine are seemingly without limit.
View Article and Find Full Text PDFInt J Radiat Oncol Biol Phys
December 2015
Department of Radiation Oncology, University of Florida School of Medicine, Gainesville, Florida; Shands Cancer Center, University of Florida School of Medicine, Gainesville, Florida.
Purpose: To perform a prospective, multi-institutional, phase 2 study of a substantial decrease in concurrent chemoradiation therapy (CRT) intensity as primary treatment for favorable-risk, human papillomavirus-associated oropharyngeal squamous cell carcinoma.
Methods And Materials: The major inclusion criteria were: (1) T0 to T3, N0 to N2c, M0; (2) human papillomavirus or p16 positive; and (3) minimal/remote smoking history. Treatment was limited to 60 Gy intensity modulated radiation therapy with concurrent weekly intravenous cisplatinum (30 mg/m(2)).
J Clin Oncol
November 2015
Anita D'Souza, Mei-Jie Zhang, Jiaxing Huang, and Parameswaran Hari, Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin; Mei-Jie Zhang, Institute for Health and Society, Medical College of Wisconsin, Milwaukee; Natalie S. Callander, University of Wisconsin Carbone Cancer Center, Madison, WI; Angela Dispenzieri, Morie A. Gertz, Robert A. Kyle, and Shaji Kumar, Mayo Clinic, Rochester, MN; Baldeep Wirk, Seattle Cancer Care Alliance, Seattle, WA; Raymond L. Comenzo, Tufts Medical Center, Boston; Muthalagu Ramanathan, University of Massachusetts Memorial Medical Center, Worcester, MA; Robert Peter Gale, Hematology Research Centre, Imperial College London, London, United Kingdom; Hillard M. Lazarus, Seidman Cancer Center, University Hospitals Case Medical Center, Cleveland, OH; Bipin N. Savani and Robert F. Cornell, Vanderbilt University Medical Center, Nashville, TN; Brendan M. Weiss and Dan T. Vogl, Abramson Cancer Center, University of Pennsylvania Medical Center, Philadelphia, PA; César O. Freytes, South Texas Veterans Health Care System and University of Texas Health Science Center San Antonio, San Antonio; Rammurti T. Kamble, Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX; Emma C. Scott, Center for Hematologic Malignancies, The Knight Cancer Institute, Oregon Health and Science University, Portland, OR; Heather J. Landau, Memorial Sloan Kettering Cancer Center; Tomer M. Mark, Weill Cornell Medical College, New York, NY; Jan S. Moreb, Shands HealthCare and University of Florida, Gainesville; Taiga Nishihori, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL; Luciano J. Costa, University of Alabama at Birmingham, Birmingham, AL; Richard F. Olsson, Karolinska Institutet, Stockholm; Centre for Clinical Research Sörmland, Uppsala University, Uppsala, Sweden; Siddhartha Ganguly, University of Kansas Medical Center, Kansas City, KS; Tamila L. Kindwall-Keller, University of Virginia Health Sys
Purpose: Autologous hematopoietic cell transplantation, or autotransplantation, is effective in light-chain amyloidosis (AL), but it is associated with a high risk of early mortality (EM). In a multicenter randomized comparison against oral chemotherapy, autotransplantation was associated with 24% EM. We analyzed trends in outcomes after autologous hematopoietic cell transplantation for AL in North America.
View Article and Find Full Text PDFFertil Steril
November 2015
Department of Biostatistics, Yale University School of Public Health, New Haven, Connecticut. Electronic address:
Objective: To identify variables associated with retention (or dropout) in infertility clinical trials. Retention of subjects in randomized controlled clinical trials (RCTs) has received considerable attention, but there have been few consistent findings.
Design: Secondary analysis of data from RCTs.
Nurs Adm Q
December 2016
University of Alabama at Birmingham, University Hospital, Birmingham, Alabama (Mss Ryan, Harris, Mattox and Camp); UF Health Shands at the University of Florida, Gainesville, Florida (Ms Singh); and Clinical and Global Partnerships, University of Alabama at Birmingham, School of Nursing, Birmingham, Alabama (Dr Shirey).
Nursing leadership opportunities to improve quality and align resources in health care exist. An estimated 18% of United States gross domestic product is spent on health care delivery systems that produce poor outcomes. The purpose of this article was to describe how quality improvement and implementation science initiatives enhance outcomes using nursing leadership strategies that play an integral role in aligning key colleagues to drive the collaborative process.
View Article and Find Full Text PDFJ Addict Med
April 2016
From the Division of Gynecology (KRR), Department of Obstetrics and Gynecology, University of Florida College of Medicine, Gainesville, FL; Department of Psychiatry (KRR, GR), University of Florida College of Medicine, Gainesville, FL; University of Florida College of Medicine (IE, SD), Gainesville, FL; and Department of Psychiatry and McKnight Brain Institute MG, University of Florida College of Medicine, Gainesville, FL.
Objectives: To investigate the length of stay for observation and treatment of neonatal abstinence syndrome (NAS), as well as the hospital costs associated with the medical care of affected newborns.
Methods: A retrospective chart review was conducted at Shands Hospital at the University of Florida, Gainesville, Florida. Data were collected for newborns diagnosed with NAS, including their hospital length of stay and the associated hospital charges, from December 1, 2008, to November 30, 2011.
Pract Radiat Oncol
October 2016
Department of Radiation Oncology, University of Florida, Gainesville, Florida. Electronic address:
J Pediatr
April 2015
Department of Pediatrics, University of Florida, Gainesville, FL.
Am J Health Syst Pharm
April 2015
Kara D. Krzan, Pharm.D., M.S., is Chief of Pediatric Clinical Pharmacy Services, University of Florida Health Shands Hospital, Gainesville; at the time of the project described herein, she was Postgraduate Year 2 Resident in Health System Pharmacy Administration, Nationwide Children's Hospital, Columbus, OH. Jenna Merandi, Pharm.D., M.S., is Medication Safety Pharmacist; and Shelly Morvay, Pharm. D., is Medication Safety Pharmacist, Nationwide Children's Hospital. Jay Mirtallo, M.S., B.S.Pharm., BCNSP, FASHP, FASPEN, is Professor of Clinical Pharmacy and Director, Master of Science degree program in Health System Pharmacy, Division of Pharmacy Practice and Administration, College of Pharmacy, The Ohio State University, Columbus.
Purpose: A formal support program for pharmacy employees involved in adverse drug events, patient-related injuries, and other traumatic work experiences is described.
Summary: Healthcare workers are sometimes referred to as the "second victims" of patient care mishaps due to the anxiety, loss of confidence, and career uncertainty they may experience. After a survey indicating that about 30% of its staff had been involved in a second-victim event, the Nationwide Children's Hospital (NCH) pharmacy department implemented a peer-based support initiative (the YOU Matter program) based on an established three-tiered intervention model.
Biol Blood Marrow Transplant
April 2015
Department of Medicine, Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, Wisconsin. Electronic address:
We describe baseline incidence and risk factors for new cancers in 4161 persons receiving autotransplants for multiple myeloma in the United States from 1990 to 2010. Observed incidence of invasive new cancers was compared with expected incidence relative to the US population. The cohort represented 13,387 person-years at-risk.
View Article and Find Full Text PDFBiol Blood Marrow Transplant
April 2015
Department of Medicine, Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, Wisconsin. Electronic address:
Variations in cord blood manufacturing and administration are common, and the optimal practice is not known. We compared processing and banking practices at 16 public cord blood banks (CBB) in the United States and assessed transplantation outcomes on 530 single umbilical cord blood (UCB) myeloablative transplantations for hematologic malignancies facilitated by these banks. UCB banking practices were separated into 3 mutually exclusive groups based on whether processing was automated or manual, units were plasma and red blood cell reduced, or buffy coat production method or plasma reduced.
View Article and Find Full Text PDFBiol Blood Marrow Transplant
February 2015
NIH-NCI Experimental Transplantation and Immunology Branch, Bethesda, Maryland. Electronic address:
Although transplant practices have changed over the last decades, no information is available on trends in incidence and outcome of chronic graft-versus-host disease (cGVHD) over time. This study used the central database of the Center for International Blood and Marrow Transplant Research (CIBMTR) to describe time trends for cGVHD incidence, nonrelapse mortality, and risk factors for cGVHD. The 12-year period was divided into 3 intervals, 1995 to 1999, 2000 to 2003, and 2004 to 2007, and included 26,563 patients with acute leukemia, chronic myeloid leukemia, and myelodysplastic syndrome.
View Article and Find Full Text PDFBone Marrow Transplant
February 2015
Center for International Blood and Marrow Transplant Research, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA.
Alternative donor transplantation is increasingly used for high-risk lymphoma patients. We analyzed 1593 transplant recipients (2000-2010) and compared transplant outcomes in recipients of 8/8 allele HLA-A, -B, -C and DRB1 matched unrelated donors (MUDs; n=1176), 7/8 allele HLA mismatched unrelated donors (MMUDs; n=275) and umbilical cord blood donors (1 or 2 units UCB; n=142). Adjusted 3-year non-relapse mortality of MMUD (44%) was higher as compared with MUD (35%; P=0.
View Article and Find Full Text PDFJ Oncol Pract
January 2015
Moffitt Cancer Center, Tampa; Center for Cancer Care & Research/Watson Clinic, Lakeland; Florida Cancer Specialists/Sarasota Memorial Hospital, Sarasota; Space Coast Medical Associates, Titusville; Florida Cancer Affiliates, Ocala; Robert & Carol Weissman Cancer Center at Martin Memorial, Stuart; Mayo Clinic, Jacksonville; Florida Hospital Cancer Institute, Orlando; North Broward Medical Center, Deerfield Beach; Tallahassee Memorial Healthcare, Tallahassee; and University of Florida/Shands Cancer Center, Gainesville, FL.
Purpose: Identifying and addressing psychosocial concerns is increasingly recognized as an important aspect of cancer care that needs to be improved. As part of the Florida Initiative for Quality Cancer Care, medical record reviews were conducted to evaluate cancer care, including psychosocial care, at oncology practices in Florida in 2006. Results were subsequently disseminated to the practices, and performance was reassessed at the same practices in 2009.
View Article and Find Full Text PDFPurpose: Malignancy relapse remains a major obstacle for successful allogeneic hematopoietic cell transplantation (HCT). Chronic graft-versus-host disease (cGVHD) is associated with fewer relapses. However, when studying effects of cGVHD on relapse, it is difficult to separate from acute GVHD effects as most cases of cGVHD occur within the first year after transplant at the time when acute GVHD is still active.
View Article and Find Full Text PDFBiol Blood Marrow Transplant
January 2015
Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington; Division of Medical Oncology, Department of Medicine, University of Washington School of Medicine, Seattle, Washington.
We analyzed the outcomes of patients who survived disease-free for 1 year or more after a second allogeneic hematopoietic cell transplantation (HCT) for relapsed acute leukemia or myelodysplastic syndromes between 1980 and 2009. A total of 1285 patients received a second allogeneic transplant after disease relapse; among these, 325 were relapse free at 1 year after the second HCT. The median time from first to second HCT was 17 and 24 months for children and adults, respectively.
View Article and Find Full Text PDFJ Am Coll Surg
October 2014
Department of Health Outcomes and Behavior, Tampa, FL.
Background: The Florida Initiative for Quality Cancer Care (FIQCC), composed of 11 practice sites across Florida, conducted its initial evaluation of adherence to breast cancer quality of care indicators (QCI) in 2006, with feedback provided to encourage quality improvement efforts at participating sites. In this study, our objective was to reassess changes over time resulting from these efforts.
Study Design: Quality care indicators were derived from the Quality Oncology Practice Initiative, the National Comprehensive Cancer Network, the American College of Surgeons, and expert panel consensus.
Biol Blood Marrow Transplant
November 2014
Blood & Marrow Transplant Program, Cleveland Clinic, Cleveland, Ohio. Electronic address:
We examined risk of second solid cancers after allogeneic hematopoietic cell transplantation (AHCT) using reduced-intensity/nonmyeloablative conditioning (RIC/NMC). RIC/NMC recipients with leukemia/myelodysplastic syndrome (MDS) (n = 2833) and lymphoma (n = 1436) between 1995 and 2006 were included. In addition, RIC/NMC recipients 40 to 60 years of age (n = 2138) were compared with patients of the same age receiving myeloablative conditioning (MAC, n = 6428).
View Article and Find Full Text PDFAcad Med
July 2014
Dr. Southwick is professor of medicine, Division of Infectious Diseases, Department of Medicine, College of Medicine, University of Florida, Gainesville, Florida. Ms. Lewis is case manager, UF Health Shands Hospital, Gainesville, Florida. Dr. Treloar is associate professor of nursing, College of Medicine, University of Florida, Gainesville, Florida. Dr. Cherabuddi is assistant professor of medicine, Division of Infectious Diseases, College of Medicine, University of Florida, Gainesville, Florida. Dr. Radhakrinshan is assistant professor of medicine, Division of Hospitalist Medicine, College of Medicine, University of Florida, Gainesville, Florida. Dr. Leverence is vice chairman of medicine for clinical affairs, professor of medicine, and chief, Division of Hospital Medicine, College of Medicine, University of Florida, Gainesville, Florida. Ms. Han is an undergraduate student, Department of Statistics, College of Liberal Arts and Sciences, University of Florida, Gainesville, Florida. Dr. Cottler is dean's professor and chair, Department of Epidemiology, College of Public Health and Health Professions and College of Medicine, University of Florida, Gainesville, Florida.
Problem: Teaching hospital multidisciplinary work rounds are often inefficient, delaying the completion of patient care tasks and detracting from teaching. Participants often act as working groups rather than interdependent teams. Athletic principles were used to train multidisciplinary rounding teams to adopt the systems used by manufacturing to improve the efficiency and quality of patient care, as well as teamwork and didactic teaching.
View Article and Find Full Text PDFBiol Blood Marrow Transplant
September 2014
Department of Medicine, Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, Wisconsin.
Allogeneic hematopoietic cell transplantation (HCT) can cure some chronic lymphocytic leukemia (CLL) subjects. This study compared outcomes of myeloablative (MA) and reduced-intensity conditioning (RIC) transplants from HLA-matched sibling donors (MSD) for CLL. From 1995 to 2007, information regarding 297 CLL subjects was reported to the Center of International Blood and Marrow Transplant Research; of these, 163 underwent MA and 134 underwent RIC MSD HCT.
View Article and Find Full Text PDF