1 results match your criteria: "Shandong University Jinan 250012 Shandong China guanzhao.wu@email.sdu.edu.cn.[Affiliation]"
Discovery of novel SS-31 (d-Arg-dimethylTyr-Lys-Phe-NH) derivatives as potent agents to ameliorate inflammation and increase mitochondrial ATP synthesis.
RSC Adv
September 2024
Qilu Hospital, Cheeloo College of Medicine, Shandong University Jinan 250012 Shandong China
Article Synopsis
- Neuroinflammation and mitochondrial function are vital for neuron health, and SS-31 is a peptide that helps reduce cell stress and inflammation in mitochondria.
- Researchers synthesized 19 new derivatives of SS-31, finding that two specific peptides, 5f and 5g, significantly lower inflammatory markers and boost energy production in cells.
- The study suggests that 5f and 5g have protective benefits for neurons and hold potential for treating neurodegenerative diseases like Alzheimer's linked to inflammation and mitochondrial issues.