6 results match your criteria: "Shandong University Center for Orthopedics[Affiliation]"
[Opportunities and challenges in the development of artificial intelligence research in spinal surgery].
Zhonghua Yi Xue Za Zhi
October 2024
Department of Orthopedics of the Second Hospital of Shandong University, Department of Orthopedics of Qilu Hospital, Shandong University Center for Orthopedics, International Science and Technology Cooperation Base of Spinal Cord Injury, Jinan 250033, China.
Artificial intelligence has emerged as a game-changer in the field of spine surgery, offering transformative diagnostic and therapeutic approaches for spinal conditions. The application of AI in spine research encompasses a diverse range of diseases, with usage scenarios becoming increasingly widespread and technological integration going deeper. AI technology shows immense promise and value in the diagnosis of spinal diseases, the formulation of treatment strategies, surgical navigation, prognostic evaluation, and postoperative rehabilitation.
View Article and Find Full Text PDFMachine learning identifies key cells and therapeutic targets during ferroptosis after spinal cord injury.
Neural Regen Res
July 2024
Department of Orthopedics, Tianjin Medical University General Hospital, International Science and Technology Cooperation Base of Spinal Cord Injury, Tianjin Key Laboratory of Spine and Spinal Cord, Tianjin, China.
Article Synopsis
- Ferroptosis is linked to injury response after spinal cord damage, involving iron imbalance and lipid damage.
- Researchers analyzed RNA sequencing data to identify key genes Atf3 and Piezo1 associated with ferroptosis and highlighted their relationship with macrophages/microglia.
- A mouse model study showed that treating with cycloheximide improved recovery and altered inflammatory cytokine levels, indicating potential therapeutic pathways for spinal cord injury recovery.
Fully biodegradable and self-powered nerve guidance conduit based on zinc-molybdenum batteries for peripheral nerve repair.
Biosens Bioelectron
November 2024
School of Materials Science and Engineering, The Key Laboratory of Advanced Materials of Ministry of Education, State Key Laboratory of New Ceramics and Fine Processing, Laboratory of Flexible Electronics Technology, Tsinghua University, Beijing, 100084, China. Electronic address:
Peripheral nerve injury (PNI) poses a significant public health issue, often leading to muscle atrophy and persistent neuropathic pain, which can drastically impact the quality of life for patients. Electrical stimulation represents an effective and non-pharmacological treatment to promote nerve regeneration. Yet, the postoperative application of electrical stimulation remains a challenge.
View Article and Find Full Text PDFEpidemiological and clinical features, treatment status, and economic burden of traumatic spinal cord injury in China: a hospital-based retrospective study.
Neural Regen Res
May 2024
Department of Orthopedics, The Second Hospital, Cheeloo College of Medicine; Department of Orthopedics, Shandong University Center for Orthopedics, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Shandong; Department of Orthopedics, Tianjin Medical University General Hospital, International Science and Technology Cooperation Base of Spinal Cord Injury, Tianjin Key Laboratory of Spine and Spinal Cord, Tianjin, China.
Article Synopsis
- Traumatic spinal cord injury (SCI) poses serious risks, including permanent disability and death, and China has the highest number of patients affected.
- This study analyzed data from 13,465 SCI patients across China from 2013 to 2018, focusing on their clinical features, treatment methods, and the economic impact of their injuries.
- Results showed that surgery rates were high, but timely interventions were scarce, with overall treatment costs decreasing, although daily costs remained stable, indicating a need for improved healthcare strategies.
Ferroptosis inhibition protects vascular endothelial cells and maintains integrity of the blood-spinal cord barrier after spinal cord injury.
Neural Regen Res
November 2023
Shandong University Center for Orthopedics, Department of Orthopedics, Qilu Hospital of Shandong University, Cheeloo College of Medicine, Shandong University, Jinan, Shandong Province; Tianjin Key Laboratory of Spine and Spinal Cord, National Spinal Cord Injury International Cooperation Base, Department of Orthopedics, Tianjin Medical University General Hospital, Tianjin, China.
Maintaining the integrity of the blood-spinal cord barrier is critical for the recovery of spinal cord injury. Ferroptosis contributes to the pathogenesis of spinal cord injury. We hypothesized that ferroptosis is involved in disruption of the blood-spinal cord barrier.
View Article and Find Full Text PDFApplication value of biofluid-based biomarkers for the diagnosis and treatment of spinal cord injury.
Neural Regen Res
May 2022
Department of Orthopedics; International Science and Technology Cooperation Base of Spinal Cord Injury, Tianjin Key Laboratory of Spine and Spinal Cord, Tianjin Medical University General Hospital, Tianjin; Department of Orthopedics, Qilu Hospital; Shandong University Center for Orthopedics, Cheeloo College of Medicine, Shandong University, Jinan, Shandong Province, China.
Recent studies in patients with spinal cord injuries (SCIs) have confirmed the diagnostic potential of biofluid-based biomarkers, as a topic of increasing interest in relation to SCI diagnosis and treatment. This paper reviews the research progress and application prospects of recently identified SCI-related biomarkers. Many structural proteins, such as glial fibrillary acidic protein, S100-β, ubiquitin carboxy-terminal hydrolase-L1, neurofilament light, and tau protein were correlated with the diagnosis, American Spinal Injury Association Impairment Scale, and prognosis of SCI to different degrees.
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