Bridging host-guest chemistry with molecule chemistry-covalent organic polyrotaxanes (COPRs): from synthesis to inactivation of bacterial pathogens.

As a thriving artificial material, covalent organic frameworks (COFs), boasting inherent structural designability and functional adaptability, and with compositions akin to biological macromolecules, have emerged as a rising star in the field of material science. However, the progression of COFs is significantly impeded by the arduous and intricate preparation procedures of novel building blocks, as well as the inefficient development process of new reactions. An efficient, uncomplicated, and versatile functionalization approach, which has the potential to not only facilitate customized preparation of COFs based on application demands but also enable precise performance control, has become a focal point of research.