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Associations of Multimorbidity with Cerebrospinal Fluid Biomarkers for Neurodegenerative Disorders in Early Parkinson's Disease: A Crosssectional and Longitudinal Study.
Curr Alzheimer Res
October 2024
School of Clinical Medicine, Shandong Second Medical University (formerly Weifang Medical University), Weifang 261000, Shandong, China.
Article Synopsis
- The study investigates the relationship between multimorbidity status (having multiple long-term conditions) and cerebrospinal fluid (CSF) biomarkers linked to neurodegenerative disorders in early-stage Parkinson's patients.
- A total of 827 participants were analyzed, including 638 with Parkinson's disease and 189 healthy controls, using regression models for both cross-sectional and longitudinal data.
- Results revealed that higher numbers of long-term conditions were associated with significant differences in various CSF biomarker levels, indicating that multimorbidity could increase neuronal damage in neurodegenerative diseases.