A novel approach for target deconvolution from phenotype-based screening using knowledge graph.

Deconvoluting drug targets is crucial in modern drug development, yet both traditional and artificial intelligence (AI)-driven methods face challenges in terms of completeness, accuracy, and efficiency. Identifying drug targets, especially within complex systems such as the p53 pathway, remains a formidable task. The regulation of this pathway by myriad stress signals and regulatory elements adds layers of complexity to the discovery of effective p53 pathway activators.

Synthesis of ZIF-67 composite lignin hydrogel and its catalytic degradation of naphthalene by PMS in wastewater.

The incorporation of ZIF-67 into hydrogels for wastewater pollutant remediation has been widely studied, but the synthesis often requires organic solvents such as methanol or ethanol, which can result in the generation of toxic liquid waste. In this study, a novel hydrogel (ZIF-67@SL) was synthesized by integrating ZIF-67 into a dual-network system of sodium lignosulfonate (SL) and acrylamide (AM) using an in situ precipitation method in water. The material was characterized by XRD, FTIR, XPS, SEM, TEM, BET, and TGA analyses.

Prediction of OCT contours of short-term response to anti-VEGF treatment for diabetic macular edema using generative adversarial networks.

Diabetic macular edema (DME) stands as a leading cause for vision loss among the working-age population. Anti-vascular endothelial growth factor (VEGF) agents are currently recognized as the first-line treatment. However, a significant portion of patients remain insensitive to anti-VEGF, resulting in sustained visual impairment.

Rh single atoms anchored in hollow microflower MoS/sulfur-vacancy rich CdZnS with dual proton reduction sites for enhanced photocatalytic hydrogen generation.

Modifying CdZnS with precious metal at the atomic scale is a promising approach for maximizing its photocatalytic performance. Herein, Rh single atoms (Rh) were successfully anchored on hollow microflower MoS/sulfur-vacancy-rich CdZnS (CZS-SVs) to boost H generation. The optimal catalyst Rh@MoS/CZS-SVs reaches a H productivity of 39,827 μmol h g, representing 5.

Atypical Patients With Severe Fever With Thrombocytopenia Syndrome.

Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne disease with a high fatality rate. The clinical diagnosis criteria mainly rely on white blood cell (WBC) and platelet (PLT), which, however, are of limited usage in identifying atypical SFTS. A multicenter study was performed in two hospitals from 2011 to 2023.

Quantitative pre-clinical imaging of hypoxia and vascularity using MRI and PET.

During hypoxia, tissues are subjected to an inadequate oxygen supply, disrupting the balance needed to maintain normal function. This deficiency can occur due to reduced oxygen delivery caused by impaired blood flow or a decline in the blood's ability to carry oxygen. In tumors, hypoxia and vascularization play crucial roles, shaping their microenvironments and influencing cancer progression, response to treatment and metastatic potential.

Preventive vs. therapeutic effects of Shoutai Wan: Maintaining an acidic microenvironment at the maternal-fetal interface to promote angiogenesis and minimize pregnancy loss in RSA mice.

Ethnopharmacological Relevance: The classic TCM prescription, Shoutai Wan (STW), is extensively used in clinical settings to manage threatened miscarriage and Recurrent spontaneous abortion (RSA). The complexity of pregnancy physiology, coupled with diverse etiologies, and the specificity of energy metabolism for normal embryo attachment and development, pose challenges to clinical diagnosis and treatment. The specific molecular mechanisms of how STW regulates these biological processes and contributes to the treatment of RSA remain to be elucidated.

NiFe-based arrays with manganese dioxide enhance chloride blocking for durable alkaline seawater oxidation.

Seawater splitting is increasingly recognized as a promising technique for hydrogen production, while the lack of good electrocatalysts and detrimental chlorine chemistry may hinder further development of this technology. Here, the interfacial engineering of manganese dioxide nanoparticles decorated on NiFe layered double hydroxide supported on nickel foam (MnO@NiFe LDH/NF) is reported, which works as a robust catalyst for alkaline seawater oxidation. Density functional theory calculations and experiment findings reveal that MnO@NiFe LDH/NF can selectively enrich OH and repel Cl in oxygen evolution reaction (OER).

WTAP knockdown inhibits cell migration through regulating SNAIL1 expression in colorectal cancer.

Objective: N6-methyladenosine (m6A) modification is the most prevalent mRNA modification in carcinogenesis and it plays a crucial role. WTAP, an m6A RNA methyltransferase, is functionally significant in various cancers; however, the specific role and functional mechanism in colorectal cancer (CRC) remain poorly understood.

Method: In this study, we utilized Gene Expression Profiling Interactive Analysis (GEPIA) to compare WTAP expression in CRC and normal tissues.

Heparan sulfate 6-O-sulfotransferase 2 promotes gastric cancer progression by modulating the TGF-β/smad2/3 pathway.

Objective: To investigate the role of heparan sulfate 6-O-sulfotransferase 2 (HS6ST2) in gastric cancer (GC).

Methods: HS6ST2 expression in GC and adjacent normal gastric mucosa was first detected via immunohistochemical (IHC) staining. The correlation between the expression level of HS6ST2 and clinicopathological parameters were observed.

Breaking Anionic Solvation Barrier for Safe and Durable Potassium-ion Batteries Under Ultrahigh-Voltage Operation.

Ultrahigh-voltage potassium-ion batteries (PIBs) with cost competitiveness represent a viable route towards high energy battery systems. Nevertheless, rapid capacity decay with poor Coulombic efficiencies remains intractable, mainly attributed to interfacial instability from aggressive potassium metal anodes and cathodes. Additionally, high reactivity of K metal and flammable electrolytes pose severe safety hazards.

Current understanding and prospects for targeting neurogenesis in the treatment of cognitive impairment.

Adult hippocampal neurogenesis is linked to memory formation In the adult brain, with new neurons in the hippocampus exhibiting greater plasticity during their immature stages compared to mature neurons. Abnormal adult hippocampal neurogenesis is closely associated with cognitive impairment in central nervous system diseases. Targeting and regulating adult hippocampal neurogenesis have been shown to improve cognitive deficits.

PRMT6 promotes colorectal cancer progress via activating MYC signaling.

Colorectal cancer (CRC) remains a major global health challenge, with high rates of incidence and mortality. This study investigates the role of protein arginine methyltransferase 6 (PRMT6) as an oncogene in CRC and its mechanistic involvement in tumor progression. We found that PRMT6 is significantly overexpressed in CRC tissues compared to adjacent normal tissues and is associated with poorer patient survival.

Unveiling the role of MDH1 in breast cancer drug resistance through single-cell sequencing and schottenol intervention.

This study utilizes single-cell RNA sequencing data to reveal the transcriptomic characteristics of breast cancer and normal epithelial cells. Nine significant cell populations were identified through stringent quality control and batch effect correction. Further classification of breast cancer epithelial cells based on the PAM50 method and clinical subtypes highlighted significant heterogeneity between triple-negative breast cancer (TNBC) and non-triple-negative breast cancer (NTNBC).

Pretreatment red blood cell distribution width as a predictive marker for postoperative complications after laparoscopic pancreatoduodenectomy.

Background: Red blood cell distribution width (RDW) is associated with the development and progression of various diseases.

Aim: To explore the association between pretreatment RDW and short-term outcomes after laparoscopic pancreatoduodenectomy (LPD).

Methods: A total of 804 consecutive patients who underwent LPD at our hospital between March 2017 and November 2021 were retrospectively analyzed.

An all-in-one microfluidic cryopreservation system and protocols with gradually increasing CPA concentration.

In regular biosample cryopreservation operations, dropwise pipetting and continuous swirling are ordinarily needed to prevent cell damage ( sudden osmotic change, toxicity and dissolution heat) caused by the high-concentration cryoprotectant (CPA) addition process. The following CPA removal process after freezing and rewarming also requires multiple sample transfer processes and manual work. In order to optimize the cryopreservation process, especially for trace sample preservation, here we present a microfluidic approach integrating CPA addition, sample storage, CPA removal and sample resuspension processes on a 30 × 30 × 4 mm three-layer chip.

Construction and application of optimized model for mine water inflow prediction based on neural network and ARIMA model.

Mine water influx is a significant geological hazard during mine development, influenced by various factors such as geological conditions, hydrology, climate, and mining techniques. This phenomenon is characterized by non-linearity and high complexity, leading to frequent water accidents in coal mines. These accidents not only impact coal production quality but also jeopardize the safety of mine staff.

A functional integral approach to magnon mediated plasmon friction.

In this paper, we discuss quantum friction in a system formed by two metallic surfaces separated by a ferromagnetic intermedium of a certain thickness. The internal degrees of freedom in the two metallic surfaces are assumed to be plasmons, while the excitations in the intermediate material are magnons, modeling plasmons coupled to magnons. During relative sliding, one surface moves uniformly parallel to the other, causing friction in the system.

USP1 promotes pancreatic cancer progression and autophagy by deubiquitinating ATG14.

Pancreatic ductal adenocarcinoma (PDAC) is characterized by extremely poor prognosis, high mortality and limited therapeutic strategy. Autophagy is hyperactivated in PDAC and targeting autophagy are emerging as promising therapeutic strategies. The dysfunction of deubiquitinase USP1 results in tumorigenesis and chemotherapy resistance.

Enormous Out-of-Plane Charge Rectification and Conductance through Two-Dimensional Monolayers.

Heterogeneous integration of emerging two-dimensional (2D) materials with mature three-dimensional (3D) silicon-based semiconductor technology presents a promising approach for the future development of energy-efficient, function-rich nanoelectronic devices. In this study, we designed a mixed-dimensional junction structure in which a 2D monolayer (e.g.

Apelin-13 inhibits ischemia-reperfusion mediated podocyte apoptosis by reducing m-TOR phosphorylation to enhance autophagy.

Podocytes are essential to maintain the normal filtration function of glomerular basement membrane, which could be injured by ischemia-reperfusion. As complicated function of autophagy in terminal differentiated podocytes, autophagy dysfunction might contribute to I/R induced renal dysfunction following glomerular filtration membrane (GFM) injuries. Meanwhile, apelin-13, an endogenous polypeptide, has been proved to be effective in regulating autophagy and apoptosis in podocytes.

Metal Bis(acyclic diaminocarbene)-Derived Homochiral Organometallic Frameworks: Synthesis and Asymmetric Catalytic Application.

As an indispensable member of the reticular material family, metal-carbon-based organometallic frameworks (OMFs) remain largely underexplored, and no chiral OMFs (COMFs) have been reported thus far. Herein, we first report the construction of COMFs from a Pd-isocyanide OMF via nucleophilic addition to the Pd-isocyanide moiety with optically pure amines. The obtained Pd-bis(acyclic diaminocarbene) (Pd-BADC)-derived chiral OMFs display excellent applicability and can be reusable chiral catalysts to highly promote asymmetric Strecker and Suzuki-Miyaura cross-coupling reactions in a heterogeneous way.

An sp Carbon-Conjugated Covalent Organic Framework for Fusing Lipid Droplets and Engineered Macrophage Therapy.

Engineered immune cell therapy has proven to be a transformative cancer treatment despite the challenges of its prohibitive costs and manufacturing complexity. In this study, we propose a concise "lipid droplet fusion" strategy for engineering macrophages. Because of the integration of hydrophobic alkyl chains and π-conjugated structures, the mildly synthesized spC-conjugated covalent organic framework (COF) UM-101 induced lipid droplet fusion and metabolic reprogramming of macrophages, thus promoting their antitumor classical activation.

Self-Reconstruction of High Entropy Alloys for Efficient Alkaline Hydrogen Evolution.

Alkaline water (HO) electrolysis is currently a commercialized green hydrogen (H) production technology, yet the unsatisfactory hydrogen evolution reaction (HER) performance severely limits its energy conversion efficiency and cost reduction. Herein, PtRuFeCoNi high entropy alloys (HEAs) is synthesized and subsequently exploited electrochemically induced structural oxidation processes to construct self-reconfigurable HEAs, as an efficient alkaline HER catalyst. The optimized self-reconstructed PtRuFeCoNi HEAs with the HEAs and cobalt rutheniate interface (HEAs-CoRuO) exhibits excellent alkaline HER performance, requiring just 11.