Association of the triglyceride-glucose index with the occurrence of non-alcoholic fatty liver disease and mortality in elderly inpatients: a prospective observational study.

Introduction: non-alcoholic fatty liver disease (NAFLD) is a disease in which there is excessive fat deposition in hepatocytes due to hepatoprotective factors. Objectives: to assess the association of the triglyceride-glucose index with the occurrence of non-alcoholic fatty liver disease and mortality in elderly inpatients. To identify the TyG index as a predictive factor of NAFLD.

LINC01004-SPI1 axis-activated SIGLEC9 in tumor-associated macrophages induces radioresistance and the formation of immunosuppressive tumor microenvironment in esophageal squamous cell carcinoma.

Radioresistance and immunosuppression remain the major obstacles in the anti-cancer treatments. This work studies the functions of sialic acid binding Ig like lectin 9 (SIGLEC9) and its related molecules in radioresistance and immunosuppression in esophageal squamous cell carcinoma (ESCC). The single-cell analysis showed that SIGLEC9 was mainly expressed on tumor-associated macrophages (TAMs).

A novel promising neuroprotective agent: Ganoderma lucidum polysaccharide.

Nervous system diseases (NSDs) are characterized by a wide range of symptoms, a complex pathophysiology, an unclear etiology, a great deal of variation in treatment response, and lengthy therapy cycles, all of which pose considerable hurdles to clinical treatment. A traditional valuable medicine known as Ganoderma lucidum (GL) has a significant role to play in preserving health and treating diseases. Ganoderma lucidum polysaccharides (GLP) is one of the cardinal effective active ingredients of GL, which has a number of pharmacological actions, including liver protection, immune regulation, antioxidant activity, anticancer activity, antibacterial activity, and antiviral activity.

Immune subtype identification and multi-layer perceptron classifier construction for breast cancer.

Introduction: Breast cancer is a heterogeneous tumor. Tumor microenvironment (TME) has an important effect on the proliferation, metastasis, treatment, and prognosis of breast cancer.

Methods: In this study, we calculated the relative proportion of tumor infiltrating immune cells (TIICs) in the breast cancer TME, and used the consensus clustering algorithm to cluster the breast cancer subtypes.

Programmable T-Junction Structure-Assisted CRISPR/Cas12a Electrochemiluminescence Biosensor for Detection of Sa-16S rDNA.

Herein, a strand displacement amplification (SDA)-assisted CRISPR/Cas12a (LbCpf1) electrochemiluminescence (ECL) biosensor was fabricated for ultrasensitive identification of (Sa)-16S rDNA. A porphyrinic Zr metal-organic framework (MOF) (PCN-224) nanomaterial was prepared as the coreactant accelerator, which promoted the conversion of SO and SO, thus enhancing the reaction with CdS quantum dots (QDs) and amplifying the ECL emission signal. Meanwhile, with the presence of Sa-16S rDNA, the auxiliary probes and primers stimulated the SDA reaction under the action of Klenow fragment (3'-5' exo-) and Nt.

Efficacy and Safety of Yanggan Jian in Hepatitis B Virus-related Decompensated Cirrhosis: A Randomized, Double-blind, Controlled Trial.

Background And Aims: The aim was to evaluate the efficacy and safety of Yanggan Jian (YGJ) in HBV-infected patients with decompensated cirrhosis.

Methods: This randomized, double-blind controlled trial enrolled 160 patients with HBV-related decompensated cirrhosis who were already receiving or about to start antiviral therapy. Patients were randomly assigned to receive YGJ or placebo for 24 weeks, and were followed-up to 36 weeks.

Artificial intelligence in early diagnosis and prevention of oral cancer.

The global occurrence of oral cancer (OC) has increased in recent years. OC that is diagnosed in its advanced stages results in morbidity and mortality. The use of technology may be beneficial for early detection and diagnosis and thus help the clinician with better patient management.

Screening of potential inhibitors targeting the main protease structure of SARS-CoV-2 molecular docking.

The novel coronavirus disease (COVID-19) caused by SARS-CoV-2 virus spreads rapidly to become a global pandemic. Researchers have been working to develop specific drugs to treat COVID-19. The main protease (M) of SARS-CoV-2 virus plays a pivotal role in mediating viral replication and transcription, which makes it a potential therapeutic drug target against COVID-19.

Investigation and Analysis of 49343 Case Women's Vaginal Microecology.

Background: We aimed to investigate the pathogen infection in vaginal secretions of women in Linyi area.

Methods: From October 2016 to September 2018, a total of 49,343 vaginal secretion specimens from women who attended Women and Children's Health Care Hospital of Linyi District, Shandong Province, China were used to detect the cleanliness, , clue cells, , etc. with Ultra-high power microscopy.

Hierarchical microtubes constructed using Fe-doped MoS nanosheets for biosensing applications.

The structural design of multiple functional components could enhance the synergistic catalytic performance of MoS-based composites in enzyme-like catalysis. Herein, one-dimensional (1D) Fe-MoS microtubes were designed to prepare tubular Fe-doped MoS composites with MoO microrods as self-sacrificing precursors. Remarkably, the results indicated that the generated ammonia released from the sulfidation process led to the dissolution of MoO cores and the generation of a tubular structure.

A ratiometric fluorescent nanoprobe for ultrafast imaging of peroxynitrite in living cells.

For ratiometrically imaging peroxynitrite (ONOO) in living cells, we devised and fabricated a novel fluorescent nanoprobe, NC-NP, in this study. To achieve ratiometric fluorescence response towards ONOO, NC-NP used 3-(2-benzothiazolyl) coumarin (Cou-Bz) as the internal reference and 1,8-naphthimide derivative (Naph-PN) as a fluorescent ONOO probe. These compounds were incorporated into an amphiphilic block polymer called Pluronic F-127.

Drug and therapeutics committee interventions in managing irrational drug use and antimicrobial stewardship in China.

This study aimed to investigate the key points in the transformation of the functions of the Drug and Therapeutics Committee (DTC) of the Shandong Provincial Third Hospital and how to provide full authority to its role in the control of rational drug use, especially in the management of antibiotic use. A prescription review management group, antimicrobial stewardship group, and rational drug use service group were established under the DTC. From January 2016 to December 2021, each group played a role in promoting rational drug use and antimicrobial stewardship.

Pharmacovigilance of cutaneous adverse drug reactions in associations with drugs and medical conditions: a retrospective study of hospitalized patients.

Background: Cutaneous adverse drug reaction (CADR) is a common problem in clinical medication. This study aimed to investigate the correlation between clinical drug application and CADR occurrence as evidence for preventive strategies and rational clinical drug use.

Methods: We analyzed the characteristics of CADRs of 858 patients admitted to Shandong Provincial Third Hospital from March 2007 to December 2018.

Optimization and evaluation of resveratrol amorphous solid dispersions with a novel polymeric system.

The preparation of amorphous solid dispersions using polymers is a commonly used formulation strategy for enhancing the solubility of poorly water-soluble drugs. However, a single polymer often does not bring significantly enhance the solubility or amorphous stability of a poorly water-soluble drug. We found an application of a unique and novel binary polymeric blend in the preparation of solid dispersions.

Dextran Sulfate Inhibits Angiogenesis and Invasion of Gastric Cancer by Interfering with M2-type Macrophages Polarization.

Purpose: To explore the effect of dextran sulfate (DS) on the angiogenesis, invasion, and migration of gastric cancer cells by interfering with the polarization of M2-type macrophages.

Methods: The infiltration of M2-type macrophages and microvascular density in gastric cancer and paracancerous tissues were analyzed using immunohistochemistry and immunofluorescence. The effects of DS on M2-type macrophages and the angiogenesis in metastatic tumors were investigated in the nude mice intraperitoneal metastasis model using immunohistochemistry and western blot.

[Mechanisms of liver-soothing and mind-regulating acupuncture mediating opioid receptor participated in the treatment of migraine].

Objective: To observe the effect of "Shugan Tiaoshen"(liver-soothing and mind-regulating) acupuncture on behavior reactions, opioid receptor expressions in the anterior cingulate cortex tissue and inflammatory factors in the serum in migraine rats, in order to explore its mechanism underlying improvement of migraine.

Methods: In the first part of this study, forty male Wistar rats were randomized into control, model, routine acupuncture and "Shugan Tiaoshen" acupuncture groups (=10/group), and in the second part, other 40 more male Wistar rats were randomized into low, medium and high dosage of blocker of μopioid receptor (OPRM）CTOP5 and PBS groups (=10/group, for validating the involvement of opioid receptor in the effect of "Shugan Tiaoshen"). The migraine model was established by subcutaneous injection of glyceryl trinitrate.

Artificial Intelligence-Based CT Imaging on Diagnosis of Patients with Lumbar Disc Herniation by Scalpel Treatment.

The aim of this study was to explore the application effect of computed tomography (CT) image based on active contour segmentation algorithm in the treatment of lumbar disc herniation (LDH) with scalpel. 78 patients with LDH were selected and divided into a lateral crypt block treatment group (group A) and a scalpel treatment group (group B) randomly. All the patients were examined by lumbar CT images based on artificial intelligence (AI) algorithm.

Psychometric Properties of the Chinese Revision of the Pitt Wellness Scale for People in the University Environment.

Background: The number of students enrolled in higher education in China accounts for more than one-fifth of the world, and universities, as a community of faculty, staff and scholars, currently do not have a scale that specifically assesses the well-being of the population in the environment of Chinese universities. However, the University of Pittsburgh has developed a comprehensive well-being scale, referred to as the Pitt Wellness Scale, specifically to measure people's well-being in a university environment.

Aims: Investigate the psychometric properties of the Pitt Wellness Scale in Chinese university environmental samples.

Coupled nickel-cobalt nanoparticles/N,P,S-co-doped carbon hybrid nanocages with high performance for catalysis and protein adsorption.

Carbon-supported bimetallic NiCo nanoparticles (NPs) have emerged as attractive catalysts and adsorbents for the reduction of 4-nitrophenol (4-NP) and separation of histidine-rich (His-rich) protein recently due to their low cost, high catalytic activity and good affinity for His-rich protein. In this study, new strongly coupled nickel-cobalt alloy/N,P,S co-doped carbon (NPSC) nanocages are rationally designed chemical etching of the ZIF-67 dodecahedron with Ni under sonication at room temperature, followed by poly(cyclotriphosphazene--4,4'-sulfonyldiphenol) (PZS) coating and subsequent carbonization treatment in a nitrogen atmosphere. When evaluated as a catalyst for 4-NP or an adsorbent for His-rich protein, the as-prepared NiCo@NPSC nanocages obtained at 700 °C show better performance than those obtained at other temperatures (500 and 900 °C).

Corrigendum: Genomic Investigation Reveals a Community Typhoid Outbreak Caused by Contaminated Drinking Water in China, 2016.

[This corrects the article DOI: 10.3389/fmed.2022.

Corrigendum: Sacral Curvature in Addition to Sacral Ratio to Assess Sacral Development and the Association With the Type of Anorectal Malformations.

[This corrects the article DOI: 10.3389/fped.2021.

Ginsenoside Rb2: A review of pharmacokinetics and pharmacological effects.

Ginsenoside Rb2 is an active protopanaxadiol-type saponin, widely existing in the stem and leave of ginseng. Rb2 has recently been the focus of studies for pharmaceutical properties. This paper provides an overview of the preclinical and clinical pharmacokinetics for Rb2, which exhibit poor absorption, rapid tissue distribution and slow excretion through urine.

Efficient Johnson-S Mixture Model for Segmentation of CT Liver Image.

To overcome the problem that the traditional Gaussian mixture model (GMM) cannot well describe the skewness distribution of the gray-level histogram of a liver CT slice, we propose a novel segmentation method for liver CT images by introducing the Johnson-SB mixture model (JMM). The Johnson-SB model not only has a flexible asymmetrical distribution but also covers a variety of other distributions as well. In this article, the parameter optimization formulas for JMM were derived by employing the expectation-maximization (EM) algorithm and maximum likelihood.

Genomic Investigation Reveals a Community Typhoid Outbreak Caused by Contaminated Drinking Water in China, 2016.

Typhoid fever is a life-threatening disease caused by serovar Typhi (. Typhi) and remains a significant public health burden in developing countries. In China, typhoid fever is endemic with a limited number of reported outbreaks.