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Am J Cancer Res
February 2023
Phase I Clinical Study Center, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Science Jinan 250117, Shandong, P. R. China.
Current anti-angiogenic therapies have changed the paradigm of treating colorectal cancer (CRC) patients with advanced diseases. However, the clinical response rate is still low at less than 10% due largely to complex angiogenic factors released by tumor cells. Exploring novel mechanisms of tumor angiogenesis and identifying alternative targets for combination therapies are therefore essential to effective inhibition of tumor vascularization and CRC development.
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