46 results match your criteria: "Shandong Engineering Research Center of Biomarker and Artificial Intelligence Application[Affiliation]"

Perfluorooctanoic acid (PFOA) has been widely documented to affect various aspects of health, including development, metabolism and neuronal function in a variety of organisms. Despite numerous reports detailing these effects, a comprehensive mechanistic model remains elusive, especially with regard to the long-term effects of PFOA, as it bioaccumulates in food chains with a long half-life. In this study, we evaluated the impact of PFOA on several critical physiological states of Drosophila melanogaster.

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Liver metabolites are involved in the progression of rheumatoid arthritis (RA), indicating a connection between the liver and joints. However, the impact and mechanism of Hepatitis B virus (HBV), a hepatotropic virus, on RA are still unclear. We investigated the correlation between HBV and RA using Mendelian randomization analysis.

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Article Synopsis
  • * Using various bioinformatics tools and laboratory techniques, the study analyzed FCN1, FCN2, and FCN3 in lung cancer subtypes, finding that their expressions were significantly lower in tumor tissues and that they showed promise as diagnostic and prognostic markers.
  • * Results indicated that FCN2 and FCN3 correlate negatively with overall survival in lung squamous cell carcinoma (LUSC), while FCN1 and FCN2 correlate positively in lung adenocarcinoma (LUAD), and FCNs are linked to immune
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Flexible Graphene Field-Effect Transistors and Their Application in Flexible Biomedical Sensing.

Nanomicro Lett

October 2024

Institute of Marine Science and Technology, Shandong University, Qingdao, 266237, Shandong, People's Republic of China.

Article Synopsis
  • * FGFETs leverage the unique properties of graphene, such as high electron mobility and biocompatibility, making them ideal for use in sensors and flexible electronics.
  • * The review covers the structure and functioning of FGFETs, their application in wearable and implantable sensors, and addresses current challenges while highlighting future research opportunities.
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Article Synopsis
  • Disulfidptosis is a new cell death mechanism that negatively impacts the prognosis for patients with hepatocellular carcinoma (HCC), particularly in cases related to hepatitis B virus (HBV).
  • A Mendelian randomization analysis showed that higher genetic susceptibility to HBV is linked to increased HCC risk, and genetic changes tied to disulfidptosis also raise this risk.
  • The study identified five specific genes (GYS1, RPN1, SLC7A11, LRPPRC, and CAPZB) that can predict the prognosis of HBV-HCC and suggested that targeting GYS1 could be a promising strategy due to its strong association with immune activity and tumor growth inhibition.
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RNF39 facilitates antiviral immune responses by promoting K63-linked ubiquitination of STING.

Int Immunopharmacol

December 2024

Department of Pathogenic Biology, Key Laboratory for Experimental Teratology of the Chinese Ministry of Education, and Key Laboratory of Infection and Immunity of Shandong Province, School of Basic Medical Science, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, China. Electronic address:

The cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) synthase (cGAS)-dependent pathway is a key DNA-sensing pathway that recognizes cytosolic DNA and plays a crucial role in initiating innate immune responses against pathogenic microbes and cancer. Various molecules have been identified as regulators of the cGAS-dependent pathway that controls innate immune responses. However, despite the important roles of Stimulator-of-interferon genes (STING) in the cGAS-dependent pathway, the regulation of its activation has not been elucidated.

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Angiogenesis is a key player in drug resistance to targeted therapies for breast cancer. The average expression of angiogenesis-related cytokines is widely associated with the treatments of target therapies for a population of cells or spheroids, overlooking the distinct responses for individuals. In this work, a highly integrated microfluidic platform is developed for the generation of monodisperse multicellular tumor spheroids (MTSs), drug treatments, and the measurement of cytokines for individual MTSs in a single chip.

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Performance Limits and Advancements in Single 2D Transition Metal Dichalcogenide Transistor.

Nanomicro Lett

August 2024

Institute of Marine Science and Technology, Shandong University, Qingdao, 266237, Shandong, People's Republic of China.

Two-dimensional (2D) transition metal dichalcogenides (TMDs) allow for atomic-scale manipulation, challenging the conventional limitations of semiconductor materials. This capability may overcome the short-channel effect, sparking significant advancements in electronic devices that utilize 2D TMDs. Exploring the dimension and performance limits of transistors based on 2D TMDs has gained substantial importance.

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Serum-volatile organic compounds in the diagnostics of esophageal cancer.

Sci Rep

July 2024

Department of Clinical Laboratory, Qilu Hospital of Shandong University, 107 Wenhua Xi Road, Jinan, 250012, Shandong, China.

The early diagnosis of esophageal cancer (EC) is extremely challenging due to a lack of effective diagnostic methods. The study presented herein aims to assess whether serum volatile organic compounds (VOCs) could be utilised as emerging diagnostic biomarkers for EC. Gas chromatography-ion mobility spectrometry (GC-IMS) was used to detect VOCs in the serum samples of 55 patients with EC, with samples from 84 healthy controls (HCs) patients analysed as a comparison.

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Resveratrol protects against a high-fat diet-induced neuroinflammation by suppressing mitochondrial fission via targeting SIRT1/PGC-1α.

Exp Neurol

October 2024

Department of Environmental Health, College of Public Health, Zhengzhou University, Zhengzhou, Henan province 450001, China; Environment and Health Innovation Team, College of Public Health, Zhengzhou University, Zhengzhou, Henan province 450001, China. Electronic address:

Article Synopsis
  • Eating a high-fat diet can hurt how our brain works and damage tiny parts of our cells called mitochondria.
  • Researchers studied rats to see how a substance called resveratrol (found in grapes) can help fix these problems.
  • The study found that resveratrol improved learning and memory by making the mitochondria work better and calming down inflammation in the brain.
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Application of as a biomarker in gastrointestinal malignancies.

World J Gastrointest Oncol

June 2024

Department of Clinical Laboratory, Qilu Hospital of Shandong University, Shandong Engineering Research Center of Biomarker and Artificial Intelligence Application, Jinan 250012, Shandong Province, China.

Article Synopsis
  • GI cancers are among the deadliest worldwide, making early diagnosis challenging due to their subtle onset and rapid progression, leading to poor treatment outcomes.
  • A specific gram-negative, spore-free anaerobic bacterium is linked to the development of various GI cancers, including colorectal and gastric cancers, through complex mechanisms.
  • Recent research indicates this bacterium could serve as a potential biomarker for GI malignancies, with its presence in stool, saliva, and serum possibly aiding in diagnosis, risk assessment, and tracking disease progression.
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Accurate classification of glomerular diseases by hyperspectral imaging and transformer.

Comput Methods Programs Biomed

September 2024

School of Control Science and Engineering, Shandong University, Qianfoshan Campus, 17923 Jingshi Road, Jinan, Shandong 250061, China. Electronic address:

Background And Objective: In renal disease research, precise glomerular disease diagnosis is crucial for treatment and prognosis. Currently reliant on invasive biopsies, this method bears risks and pathologist-dependent variability, yielding inconsistent results. There is a pressing need for innovative diagnostic tools that enhance traditional methods, streamline processes, and ensure accurate and consistent disease detection.

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RNA extraction-free reduced graphene oxide-based RT-LAMP fluorescence assay for highly sensitive SARS-CoV-2 detection.

Talanta

September 2024

Institute of Marine Science and Technology, Shandong University, Qingdao, 266237, China; School of Integrated Circuits, Shandong University, Jinan, Shandong, 250100, China. Electronic address:

Infectious diseases have always been a seriously endanger for human life and health. A rapid, accurate and ultra-sensitive virus nucleic acid detection is still a challenge to deal with infectious diseases. Here, a RNA extraction-free reduced graphene oxide-based reverse transcription-loop-mediated isothermal amplification (EF-G-RT-LAMP) fluorescence assay was developed to achieve high-throughput, rapid and ultra-sensitive SARS-CoV-2 RNA detection.

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Single-cell multiomic and exosome analyses are potent tools in various fields, such as cancer research, immunology, neuroscience, microbiology, and drug development. They facilitate the in-depth exploration of biological systems, providing insights into disease mechanisms and aiding in treatment. Single-cell isolation, which is crucial for single-cell analysis, ensures reliable cell isolation and quality control for further downstream analyses.

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Single-sEV profiling identifies the TACSTD2 + sEV subpopulation as a factor of tumor susceptibility in the elderly.

J Nanobiotechnology

May 2024

Department of Physiology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, China.

Background: Aging is a very complex physiological phenomenon, and sEVs are involved in the regulation of this mechanism. Serum samples from healthy individuals under 30 and over 60 years of age were collected to analyze differences in sEVs proteomics.

Results: Based on PBA analysis, we found that sEVs from the serum of elderly individuals highly express TACSTD2 and identified a subpopulation marked by TACSTD2.

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There is growing evidence of an elevated risk of lung cancer in patients with rheumatoid arthritis. The poor prognosis of rheumatoid arthritis-associated lung cancer and the lack of therapeutic options pose an even greater challenge to the clinical management of patients. This study aimed to identify potential molecular targets associated with the progression of rheumatoid arthritis-associated lung cancer and examine the efficacy of naringenin nanoparticles targeting cyclin B1.

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DEC1 is involved in TGF-β1-induced epithelial-mesenchymal transition of gastric cancer.

Am J Cancer Res

February 2024

Research Center of Basic Medicine, Jinan Central Hospital, Cheeloo College of Medicine, Shandong University Jinan, Shandong, China.

DEC1 is a helix-loop-helix (bHLH) transcription factor, whose deregulation has been observed in several tumors. However, the effects of the dysregulation of this gene on epithelial-mesenchymal transition (EMT) are controversial, with its roles in gastric cancer (GC) remaining unclear. In the present study, we focused on the impact of DEC1 on EMT and cell mobility in gastric cancer.

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[System analysis of the ecological distribution of bacteriophages in hospital wastewater].

Zhonghua Yu Fang Yi Xue Za Zhi

February 2024

Department of Laboratory Medicine, Qilu Hospital of Shandong University, Shandong Engineering Research Center of Biomarker and Artificial Intelligence Application,Jinan 250012, China.

Phage therapy is one of the most important tools for the treatment of infections with multi-drug resistant bacteria. Such phages are usually isolated from hospital effluents, however, no systematic study on the distribution of phages in hospital effluents has been conducted so far. The aim of this study was to isolate the corresponding phages of common pathogenic bacteria isolated in the clinic as hosts, so as to assess the ecological distribution of phages in hospital wastewater and to provide a reference for the isolation and application of phages of drug-resistant bacteria in the clinic.

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Purpose: This study aims to identify the potential necroptosis related genes (NRGs)-associated miRNAs signature and explore the impact on the prognosis of stomach adenocarcinoma (STAD).

Methods: Employing rigorous methodologies, we utilized univariate Cox, Lasso and multivariate Cox regression analyses to develop a prognostic signature. Kaplan-Meier (K-M) and ROC curves were applied to assess the prognostic value of signature in a training group and an independent test group.

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Polarized Tunneling Transistor for Ultralow-Energy-Consumption Artificial Synapse toward Neuromorphic Computing.

ACS Nano

January 2024

School of Integrated Circuits & Beijing National Research Center for Information Science and Technology (BNRist), Tsinghua University, Beijing 100084, China.

Neural networks based on low-power artificial synapses can significantly reduce energy consumption, which is of great importance in today's era of artificial intelligence. Two-dimensional (2D) material-based floating-gate transistors (FGTs) have emerged as compelling candidates for simulating artificial synapses owing to their multilevel and nonvolatile data storage capabilities. However, the low erasing/programming speed of FGTs renders them unsuitable for low-energy-consumption artificial synapses, thereby limiting their potential in high-energy-efficient neuromorphic computing.

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Background: Recently, metagenomic next-generation sequencing (mNGS) has been used in the diagnosis of infectious diseases (IDs) as an emerging and powerful tool. However, whether the complicated methodological variation in mNGS detections makes a difference in their clinical performance is still unknown. Here we conducted a method study on the clinical application of mNGS tests in the DNA detection of IDs.

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MP-HJ-1b is a novel microtubule inhibitor that we designed and reported previously. Ferroptosis is a newly identified type of nonapoptotic cell death induced by ferrous catalysis and lipid peroxidation. Here, transcriptomics, proteomics, and molecular docking analyses were combined to explore the novel effects of MP-HJ-1b on tumors.

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YAP targetome reveals activation of SPEM in gastric pre-neoplastic progression and regeneration.

Cell Rep

December 2023

Program in Developmental & Stem Cell Biology, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada. Electronic address:

Peptic ulcer disease caused by environmental factors increases the risk of developing gastric cancer (GC), one of the most common and deadly cancers in the world. However, the mechanisms underlying this association remain unclear. A major type of GC uniquely undergoes spasmolytic polypeptide-expressing metaplasia (SPEM) followed by intestinal metaplasia.

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PZT-Enabled MoS Floating Gate Transistors: Overcoming Boltzmann Tyranny and Achieving Ultralow Energy Consumption for High-Accuracy Neuromorphic Computing.

Nano Lett

November 2023

School of Integrated Circuits and Beijing National Research Center for Information Science and Technology (BNRist), Tsinghua University, Beijing 100084, China.

Low-power electronic devices play a pivotal role in the burgeoning artificial intelligence era. The study of such devices encompasses low-subthreshold swing (SS) transistors and neuromorphic devices. However, conventional field-effect transistors (FETs) face the inherent limitation of the "Boltzmann tyranny", which restricts SS to 60 mV decade at room temperature.

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Early diagnosis of esophageal cancer (EC) is extremely challenging. The study presented herein aimed to assess whether urinary volatile organic compounds (VOCs) may be emerging diagnostic biomarkers for EC. Urine samples were collected from EC patients and healthy controls (HCs).

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