A novel approach for target deconvolution from phenotype-based screening using knowledge graph.

Deconvoluting drug targets is crucial in modern drug development, yet both traditional and artificial intelligence (AI)-driven methods face challenges in terms of completeness, accuracy, and efficiency. Identifying drug targets, especially within complex systems such as the p53 pathway, remains a formidable task. The regulation of this pathway by myriad stress signals and regulatory elements adds layers of complexity to the discovery of effective p53 pathway activators.

Disentangled Active Learning on Graphs.

Active learning on graphs (ALG) has emerged as a compelling research field due to its capacity to address the challenge of label scarcity. Existing ALG methods incorporate diversity into their query strategies to maximize the gains from node sampling, improving robustness and reducing redundancy in graph learning. However, they often overlook the complex entanglement of latent factors inherent in graph-structured data.

Focusing on Cracks with Instance Normalization Wavelet Layer.

Automatic crack detection is challenging, owing to the complex and thin topologies, diversity, and background noises of cracks. Inspired by the wavelet theory, we present an instance normalization wavelet (INW) layer and embed the layer into the deep model for segmentation. The proposed layer employs prior knowledge in the wavelets to capture the crack features and filter the high-frequency noises simultaneously, accelerating the convergence of model training.

Clustering Cu-S based compounds using periodic table representation and compositional Wasserstein distance.

Crystal structure similarity is useful for the chemical analysis of nowadays big materials databases and data mining new materials. Here we propose to use two-dimensional Wasserstein distance (earth mover's distance) to measure the compositional similarity between different compounds, based on the periodic table representation of compositions. To demonstrate the effectiveness of our approach, 1586 Cu-S based compounds are taken from the inorganic crystal structure database (ICSD) to form a validation dataset.

scRGCL: a cell type annotation method for single-cell RNA-seq data using residual graph convolutional neural network with contrastive learning.

Cell type annotation is a critical step in analyzing single-cell RNA sequencing (scRNA-seq) data. A large number of deep learning (DL)-based methods have been proposed to annotate cell types of scRNA-seq data and have achieved impressive results. However, there are several limitations to these methods.

Insights into multi-scale structural evolution and dielectric response of poly(methyl acrylate) under pre-strain: A simulation study.

The structural evolution of dielectric elastomer induced by pre-strain is a complex, multi-scale process that poses a significant challenge to a deep understanding of the effect of pre-strain. Through simulation results, we identify the variation in the dielectric constant and multi-scale (electronic structure, molecular chain conformation, and aggregation structure) response of poly(methyl acrylate). As the pre-strain increases, the dielectric constant initially rises (below 200% pre-strain) and then declines (above 200% pre-strain).

Reconsidering learnable fine-grained text prompts for few-shot anomaly detection in visual-language models.

Few-Shot Anomaly Detection (FSAD) in industrial images aims to identify abnormalities using only a few normal images, which is crucial for industrial scenarios where sample training is limited. The recent advances in large-scale pre-trained visual-language models have brought significant improvements to the FSAD, which typically requires hundreds of text prompts to be manually crafted through prompt engineering. However, manually designed text prompts cannot accurately match the informative features of different categories across diverse images, and the domain gap between train and test datasets can severely impact the generalization capability of text prompts.

Enhancing urban flow prediction via mutual reinforcement with multi-scale regional information.

Intelligent Transportation Systems (ITS) are essential for modern urban development, with urban flow prediction being a key component. Accurate flow prediction optimizes routes and resource allocation, benefiting residents, businesses, and the environment. However, few methods address the spatial-temporal heterogeneity of urban flows.

Quantum secure direct communication in Internet of Vehicles.

The Internet of Vehicles (IoVs) is one of the most popular techniques among the applications of Internet of Things. The existing IoVs are mainly protected by public key cryptographic systems, which provide identity authentication and information security. Nevertheless, using the proposed Shor's algorithm, the security of all classical cryptographic schemes will be exposed to future quantum computer technologies.

Magnetoelectric Tuning of 2D Ferromagnetism in 1T-CrTe through InSe Substrate.

Electric field control of two-dimensional (2D) materials with optimized magnetic properties is not only of scientific interest but also of technological importance in terms of the functionality of various nanoscale devices. Here, we report the multiferroic control of the 2D ferromagnetism in 1T-CrTe monolayer through a ferroelectric InSe sublayer. Our results reveal the effect of polarization switching on the electronic structures and magnetic properties of 1T-CrTe/InSe heterostructures, enabling effective manipulation of their magnetic anisotropy energy (MAE) and magnetization orientation.

A comprehensive overview of recent advances in generative models for antibodies.

Therapeutic antibodies are an important class of biopharmaceuticals. With the rapid development of deep learning methods and the increasing amount of antibody data, antibody generative models have made great progress recently. They aim to solve the antibody space searching problems and are widely incorporated into the antibody development process.

Impact of community structure on the spread of epidemics on time-varying multiplex networks.

Community structure plays a crucial role in realistic networks and different communities can be created by groups of interest and activity events, and exploring the impact of community properties on collective dynamics is an active topic in the field of network science. Here, we propose a new coupled model with different time scales for online social networks and offline epidemic spreading networks, in which community structure is added into online social networks to investigate its role in the interacting dynamics between information diffusion and epidemic spreading. We obtain the analytical equations of epidemic threshold by MMC (Microscopic Markov Chain) method and conduct a large quantities of numerical simulations using Monte Carlo simulations in order to verify the accuracy of the MMC method, and more valuable insights are also obtained.

Video Abnormal Behavior Recognition and Trajectory Prediction Based on Lightweight Skeleton Feature Extraction.

Video action recognition based on skeleton nodes is a highlighted issue in the computer vision field. In real application scenarios, the large number of skeleton nodes and behavior occlusion problems between individuals seriously affect recognition speed and accuracy. Therefore, we proposed a lightweight multi-stream feature cross-fusion (L-MSFCF) model to recognize abnormal behaviors such as fighting, vicious kicking, climbing over the wall, et al.

Automatic recognition of depression based on audio and video: A review.

Depression is a common mental health disorder. With current depression detection methods, specialized physicians often engage in conversations and physiological examinations based on standardized scales as auxiliary measures for depression assessment. Non-biological markers-typically classified as verbal or non-verbal and deemed crucial evaluation criteria for depression-have not been effectively utilized.

Unveiling the Dual Role of Humidity: The Interplay with Defects Manipulating the Charge Carrier Lifetime in Metal Halide Perovskites.

Humidity has exhibited experimentally either beneficial or detrimental effects on the charge carrier lifetime of CHNHPbI perovskites, leaving the mechanism unresolved. By using ab initio nonadiabatic molecular dynamics simulations, we unveil the dual role of humidity stemming from the complex interplay between water and defects. Beneficially, water passivates iodine vacancies (V) or grain boundaries (GBs), mitigating electron trapping by reducing nonadiabatic coupling and delaying charge recombination.

The causal effect of HbA1c on white matter brain aging by two-sample Mendelian randomization analysis.

Background: Poor glycemic control with elevated levels of hemoglobin A1c (HbA1c) is associated with increased risk of cognitive impairment, with potentially varying effects between sexes. However, the causal impact of poor glycemic control on white matter brain aging in men and women is uncertain.

Methods: We used two nonoverlapping data sets from UK Biobank cohort: gene-outcome group (with neuroimaging data, ( = 15,193; males/females: 7,101/8,092)) and gene-exposure group (without neuroimaging data, ( = 279,011; males/females: 122,638/156,373)).

Lightweight Tunnel Obstacle Detection Based on Improved YOLOv5.

Considering the high incidence of accidents at tunnel construction sites, using robots to replace humans in hazardous tasks can effectively safeguard their lives. However, most robots currently used in this field require manual control and lack autonomous obstacle avoidance capability. To address these issues, we propose a lightweight model based on an improved version of YOLOv5 for obstacle detection.

TSFFM: Depression detection based on latent association of facial and body expressions.

Depression is a prevalent mental disorder worldwide. Early screening and treatment are crucial in preventing the progression of the illness. Existing emotion-based depression recognition methods primarily rely on facial expressions, while body expressions as a means of emotional expression have been overlooked.

Intrinsic ferromagnetism in two-dimensional 1T-MX monolayers with tunable magnetocrystalline anisotropy.

Two-dimensional (2D) ferromagnetic materials with tunable magnetocrystalline anisotropy (MCA) provide unique opportunities for developing the next-generation data-storage and information devices. Herein we systematically investigate the electronic and magnetic properties of the 1T-MX (M = Cr, Mn, Fe, Co; X = As, Sb) monolayers, and identify the stable 2D ferromagnets as well as their MCA energies. Notably, the results demonstrate that the biaxial strain and carrier doping effects have a significant influence on their magnetic behaviors.

Nucleotide-level prediction of CircRNA-protein binding based on fully convolutional neural network.

CircRNA-protein binding plays a critical role in complex biological activity and disease. Various deep learning-based algorithms have been proposed to identify CircRNA-protein binding sites. These methods predict whether the CircRNA sequence includes protein binding sites from the sequence level, and primarily concentrate on analysing the sequence specificity of CircRNA-protein binding.

RGB-D salient object detection via convolutional capsule network based on feature extraction and integration.

Fully convolutional neural network has shown advantages in the salient object detection by using the RGB or RGB-D images. However, there is an object-part dilemma since most fully convolutional neural network inevitably leads to an incomplete segmentation of the salient object. Although the capsule network is capable of recognizing a complete object, it is highly computational demand and time consuming.

An approach for proteins and their encoding genes synonyms integration based on protein ontology.

Background: Biological research is generating high volumes of data distributed across various sources. The inconsistent naming of proteins and their encoding genes brings great challenges to protein data integration: proteins and their coding genes usually have multiple related names and notations, which are difficult to match absolutely; the nomenclature of genes and proteins is complex and varies from species to species; some less studied species have no nomenclature of genes and proteins; The annotation of the same protein/gene varies greatly in different databases. In summary, a comprehensive set of protein/gene synonyms is necessary for relevant studies.

iCircDA-NEAE: Accelerated attribute network embedding and dynamic convolutional autoencoder for circRNA-disease associations prediction.

Accumulating evidence suggests that circRNAs play crucial roles in human diseases. CircRNA-disease association prediction is extremely helpful in understanding pathogenesis, diagnosis, and prevention, as well as identifying relevant biomarkers. During the past few years, a large number of deep learning (DL) based methods have been proposed for predicting circRNA-disease association and achieved impressive prediction performance.