Insulator-donor electron wavefunction coupling in pseudo-bilayer organic solar cells achieving a certificated efficiency of 19.18.

The incorporation of polymeric insulators has led to notable achievements in the field of organic semiconductors. By altering the blending concentration, polymeric insulators exhibit extensive capabilities in regulating molecular configuration, film crystallinity, and mitigation of defect states. However, current research suggests that the improvement in such physical properties is primarily attributed to the enhancement of thin film morphology, an outcome that seems to be an inevitable consequence of incorporating insulators.

Experimental revival of an unknown state from the past in quantum walks.

The physical process in the macroscopic world unfolds along a single time direction, while the evolution of a quantum system is reversible in principle. How to recover a quantum system to its past state is a complex issue of both fundamental and practical interests. In this article, we experimentally demonstrate a novel method for recovering the state in quantum walks (QWs), also known as full-state revival.

Case report: Bone marrow metastasis and bone marrow necrosis occurring 11 years after ductal carcinoma of the breast.

Ductal carcinoma (DCIS), a noninvasive breast cancer, rarely metastasises to distant locations. When the initial lesion is stable, bone marrow metastasis (BMM) and bone marrow necrosis (BMN) are even less common. Here, we report the case of a 47-year-old female patient who underwent localized surgery and radiotherapy for right-sided DCIS.

Under-strain Synergistic Oscillatory Twisting Manipulates the Bifunction in Rubrene Crystal.

Photophysical properties of condensed systems generally originate from collective contributions of all components in their stochastically fluctuated structures and are strongly influenced under strain of chromophores. To precisely identify how the stochastically fluctuated monomers synergistically manipulate the properties, we propose a statistic strategy over sufficient ab initio molecular dynamics (AIMD) samplings and for the first time uncover that synergistic oscillatory twisting (SOT) of neighboring under-strain monomers manipulates the bifunction of rubrene crystal.  The under-strain trunk SOT can regulate both singlet fission (SF) and triplet-triplet annihilation (TTA), enabling their coexistence and dominance switching by dynamically modulating the matching of excitation energies.

Pnictogen Bond-Mediated Coassemblies for Noncovalent Molecular Glass.

Pnictogen bond (PnB) occurring on the group-15 elements is recognized as σ- or π-hole-based interaction that has garnered attention in the fields of anion recognition and organocatalysis. Due to the polyvalent feature of pnictogens and high directionality, PnB possesses potential in the design of convergent coassembled materials with acceptors containing lone pair electrons or anions, which however is rarely explored so far. Herein, we unveil the role of antimony (Sb)-based PnB donors in producing self-assembled chiroptical materials with lone pair electron containing acceptors.

The Role and Mechanism of Perilla Alcohol in Counteracting Doxorubicin-Induced Nephrotic Syndrome.

Background: Doxorubicin (DOX) is a widely used anticancer drug; However, its nephrotoxicity limits its therapeutic efficacy. This study investigates the protective effects of Perilla Alcohol (PA) against DOX-induced nephrotic syndrome (NS), focusing on its antioxidant and anti-inflammatory properties through the nuclear factor erythroid 2-related factor 2 (Nrf2) and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) pathways.

Methods: A DOX-induced nephrotic syndrome (NS) rat model and a DOX-treated Mouse Podocyte Cell line 5 (MPC5) cell model were used to evaluate the renal protective effects of PA.

Transcriptome-Wide Association Study of Metabolic Dysfunction-Associated Steatotic Liver Disease Identifies Relevant Gene Signatures.

Metabolic dysfunction-associated steatotic liver disease (MASLD) is considered the most widespread chronic liver condition globally. Genome-wide association studies (GWAS) have pinpointed several genetic loci correlated to MASLD, yet the biological significance of these loci remains poorly understood. Initially, we applied Functional Mapping and Annotation (FUMA) to conduct a functional annotation of the MASLD GWAS summary statistics, which included data from 3242 cases and 707 631 controls.

Extending Exciton Diffusion Length via an Organic-Metal Platinum Complex Additive for High-Performance Thick-Film Organic Solar Cells.

The long exciton diffusion length (L) plays an important role in promoting exciton dissociation, suppressing charge recombination, and improving the charge transport process, thereby improving the performance of organic solar cells (OSCs), especially in thick-film OSCs. However, the limited L hinders further improvement in device performance as the film thickness increases. Here, an organic-metal platinum complex, namely TTz-Pt, is synthesized and served as a solid additive into the D18-Cl:L8-BO system.

Regional antimicrobial resistance gene flow among the One Health sectors in China.

Background: Antimicrobial resistance poses a significant threat to global health, with its spread intricately linked across human, animal, and environmental sectors. Revealing the antimicrobial resistance gene (ARG) flow among the One Health sectors is essential for better control of antimicrobial resistance.

Results: In this study, we investigated regional ARG transmission among humans, food, and the environment in Dengfeng, Henan Province, China by combining large-scale metagenomic sequencing with culturing of resistant bacterial isolates in 592 samples.

Exosomal circ_0006896 promotes AML progression via interaction with HDAC1 and restriction of antitumor immunity.

Background: Drug resistance and immune escape continue to contribute to poor prognosis in AML. Increasing evidence suggests that exosomes play a crucial role in AML immune microenvironment.

Methods: Sanger sequencing, RNase R and fluorescence in situ hybridization were performed to confirm the existence of circ_0006896.

Glecirasib in KRAS-mutated nonsmall-cell lung cancer: a phase 2b trial.

Glecirasib (JAB-21822) is a new covalent oral KRAS-G12C inhibitor. This multicenter, single-arm phase 2b study assessed the efficacy and safety of glecirasib administered orally at 800 mg daily in patients with locally advanced or metastatic KRAS-mutated nonsmall-cell lung cancer. The primary endpoint was the objective response rate (ORR) assessed by an independent review committee (IRC).

Soil fluoride enrichment process and the possible adaptation prevention principle in coal-burning fluorosis area in Southwest China.

Coal-burning fluorosis prevails in southwest China and other provinces. Although clay used as binder of briquettes was proven to cause coal-burning fluorosis, its enrichment processes remain unknown. The soils and rocks on typical geological units were sampled and simulation experiments were performed to detect the forming process of high-fluoride clay.

A multi-feature dataset of coated end milling cutter tool wear whole life cycle.

Deep learning methods have shown significant potential in tool wear lifecycle analysis. However, there are fewer open source datasets due to the high cost of data collection and equipment time investment. Existing datasets often fail to capture cutting force changes directly.

ApoB/ApoA-Ι is associated with major cardiovascular events and readmission risk of patients after percutaneous coronary intervention in one year.

Percutaneous coronary intervention (PCI) is a practical and effective method for treating coronary heart disease (CHD). This study aims to explore the influencing factors of major cardiovascular events (MACEs) and hospital readmission risk within one year following PCI treatment. Additionally, it seeks to assess the clinical value of Apolipoprotein B/Apolipoprotein A-I (ApoB/ApoA-I) in predicting the risk of one-year MACEs and readmission post-PCI.

Super-enhancer-driven SLCO4A1-AS1 is a new biomarker and a promising therapeutic target in glioblastoma.

Glioblastoma (GBM) is the most common intracranial malignancy, but current treatment options are limited. Super-enhancers (SEs) have been found to drive the expression of key oncogenes in GBM. However, the role of SE-associated long non-coding RNAs (lncRNAs) in GBM remains poorly understood.

GmERF13 mediates salt inhibition of nodulation through interacting with GmLBD16a in soybean.

While the genetic regulation of nodule formation has been well explored, the molecular mechanisms by which abiotic stresses, such as salt stress, impede nodule formation remain largely elusive. Here, we identify four APETALA2/Ethylene Responsive Factor (AP2/ERF) transcription factors, GmERF13s, that are induced by salt stress and play key roles in salt-repressed nodulation. Loss of GmERF13 function increases nodule density, while its overexpression suppresses nodulation.

Umbrella review of adjuvant photodynamic therapy for cholangiocarcinoma palliative treatment.

Background: Cholangiocarcinoma is a rare but highly fatal malignancy; numerous studies have demonstrated promising outcomes and survival rates associated with adjuvant photodynamic therapy (PDT) in the palliative treatment of cholangiocarcinoma.

Objective: To systematically evaluate the existing meta-analyses on PDT for cholangiocarcinoma, assessing evidence quality and strength while performing updated meta-analyses to refine survival outcomes.

Methods: PubMed, EMBASE, Cochrane Library, and Web of Science were systematically searched up to September 18, 2024, to identify meta-analyses and clinical studies on PDT in patients with cholangiocarcinoma.

Adipose ZFP36 protects against diet-induced obesity and insulin resistance.

Aims: Obesity, as a worldwide healthcare problem, has become more prevalent. ZFP36 is a well-known RNA-binding protein and involved in the posttranscriptional regulation of many physiological processes. Whether the adipose ZFP36 plays a role in obesity and insulin resistance remains unclear.

Benchmark of Density Functional Theory in the Prediction of C Chemical Shielding Anisotropies for Anisotropic Nuclear Magnetic Resonance-Based Structural Elucidation.

Density functional theory (DFT) calculations have emerged as a powerful theoretical toolbox for interpreting and analyzing the experimental nuclear magnetic resonance (NMR) spectra of chemical compounds. While DFT has been extensively used and benchmarked for isotropic NMR observables, the evaluation of the full chemical shielding tensor, which is necessary for interpreting residual chemical shift anisotropy (RCSA), has received much less attention, despite its recent applications in the structural elucidation of organic molecules. In this study, we present a comprehensive benchmark of carbon shielding anisotropies based on coupled cluster reference tensors taken from the NS372 benchmark data set.

Biomimetic Micro-Nanostructured Evaporator with Dual-Transition-Metal MXene for Efficient Solar Steam Generation and Multifunctional Salt Harvesting.

Solar-driven interfacial evaporation is one of the most attractive approaches to addressing the global freshwater shortage. However, achieving an integrated high evaporation rate, salt harvesting, and multifunctionality in evaporator is still a crucial challenge. Here, a novel composite membrane with biomimetic micro-nanostructured superhydrophobic surface is designed via ultrafast laser etching technology.

Metal-phenolic network biointerface-mediated cell regulation for bone tissue regeneration.

Bone tissue regeneration presents a significant challenge in clinical treatment due to inadequate coordination between implant materials and reparative cells at the biomaterial-bone interfaces. This gap underscores the necessity of enhancing interaction modulation between cells and biomaterials, which is a crucial focus in bone tissue engineering. Metal-polyphenolic networks (MPN) are novel inorganic-organic hybrid complexes that are formed through coordination interactions between phenolic ligands and metal ions.