The efficacy of virtual reality in adults during puncture biopsy: A protocol of a systematic review and meta-analysis.

Background: Puncture biopsy is a primary method for obtaining tissue or cell samples from tumors for histopathological diagnosis. However, patients often experience pain, anxiety, and discomfort during the procedure. Virtual reality is a novel technology developed through advancements in computer skill, and it is utilized in healthcare as a cognitive approach to relieve pain and relaxation.

Anti-tumor role and molecular mechanism of vanillic acid.

Vanillic Acid (VA) is an aromatic acid extracted from traditional Chinese medicine such as Angelica sinensis and Panax ginseng, which has demonstrated potent anti-cancer activity, inhibiting the onset and progression of various malignant tumors. This review highlights the principal mechanism by which VA exerts its anticancer activity, including apoptosis induction, specifically promoting the generation of intracellular reactive oxygen species (ROS), which in turn triggers mitochondrial apoptosis. Furthermore, VA disrupts the cancer cell cycle, arresting most cancer cells at the G1 phase, curtails cell migration, invasion, angiogenesis, and potentiates the therapeutic efficacy of chemotherapeutic drugs, all while minimizing adverse reactions.

Two-dimensional anion-rich NaCl crystal under ambient conditions.

The two-dimensional (2D) "sandwich" structure composed of a cation plane located between two anion planes, such as anion-rich CrI, VS, VSe, and MnSe, possesses exotic magnetic and electronic structural properties and is expected to be a typical base for next-generation microelectronic, magnetic, and spintronic devices. However, only a few 2D anion-rich "sandwich" materials have been experimentally discovered and fabricated, as they are vastly limited by their conventional stoichiometric ratios and structural stability under ambient conditions. Here, we report a 2D anion-rich NaCl crystal with sandwiched structure confined within graphene oxide membranes with positive surface potential.

PEG-rhG-CSF versus rhG-CSF in supporting neutrophil recovery after induction chemotherapy for patients with newly diagnosed acute lymphoblastic leukemia.

To compare the efficacy and safety of pegylated recombinant human granulocyte colony-stimulating factor (PEG-rhG-CSF) and rhG-CSF in the recovery of neutrophils after induction therapy in ALL patients, PEG-rhG-CSF was injected subcutaneously within 24 ~ 48 h after the end of intravenous infusion of daunorubicin/idarubicin during induction chemotherapy. In rhG-CSF group, patients were given rhG-CSF. The main outcome indexes were the incidence and duration of grade 4 chemotherapy-induced-neutropenia (CIN, ANC less than 0.

Evaluation of Auricular Acupressure on Myopia Prevention among Children Aged 6-12 Years with Pre-Myopia in China: Study Protocol of a Prospective Multi-Center Randomized Controlled Trial.

Background: The increasing prevalence of myopia among Chinese children and adolescents, especially at younger ages, has emerged as a significant concern in recent years. Pre-myopia is a key period for myopia prevention and control in children and adolescents. Previous studies suggested auricular acupressure (AA) therapy might offer a viable approach to prevent and slow down myopia progression.

Antireflux mucosal valvuloplasty versus proton pump inhibitors for the treatment of patients with gastro-oesophageal reflux disease in a tertiary healthcare centre in China: study protocol for a randomised controlled trial.

Introduction: Endoscopic antireflux therapy has shown promising potential in the treatment for gastro-oesophageal reflux disease (GERD). However, there is currently no universally accepted standard for endoscopic surgery. Therefore, we introduced antireflux mucosal valvuloplasty (ARMV), an innovative endoscopic treatment for GERD.

Skeletal Muscle Stem Cells and the Microenvironment Regulation in Sarcopenia:A Review.

Sarcopenia is an age-related degenerative skeletal muscle disorder characterized by the loss of skeletal muscle mass and function during aging.Sarcopenia can impair the elderly's ability to perform daily activities and is associated with high risks of falls,fractures,and hospitalization.It seriously affects the quality of life of the elderly and becomes one of the major health problems in the aging society.

GATA1-mediated macrophage polarization via TrkB/cGMP-PKG signaling pathway to promote the development of preeclampsia.

Background: Preeclampsia (PE) is a severe pregnancy complication characterized by hypertension and proteinuria. PE poses a substantial threat to the health of both mothers and fetuses, and currently, there is no definitive treatment available. Recent studies have indicated that the transcription factor GATA1 may be implicated in the pathological processes of PE, but the underlying mechanism remains elusive.

Preclinical studies of the falnidamol as a highly potent and specific active ABCB1 transporter inhibitor.

Background: ABCB1 overexpression is a key factor in causing multidrug resistance (MDR). As a result, it is crucial to discover effective medications against ABCB1 to overcome MDR. Falnidamol, a tyrosine kinase inhibitor (TKI) targeting the epidermal growth factor receptor (EGFR), is currently in phase 1 clinical trials for the treatment of solid tumors.

Optimal treatment approach for intracranial germinoma: a systematic review and meta-analysis.

Background: To determine the optimal treatment modality for intracranial germinoma (IG).

Materials And Methods: A search of Medline, Embase, Web of Science and Cochrane Library was conducted up to April, 2024. Pooled risk ratio (RR) and 95% confidence interval (CI) were calculated.

Evaluating the impact of weight and center of mass on comfort in head-mounted displays.

This study investigates the impact of the weight and centre of mass (COM) position of Head-Mounted Displays (HMDs) on the subjective evaluation of users during prolonged wearing tasks. This study involved 88 participants completing 1860 sets of experiments under three conditions: sitting still, turning the head, and moving, providing subjective evaluations of wearing HMDs. A static torque testing device was used to simulate neck torque under flexion states.

Effectiveness of a Multifaceted Intervention (TEMP) for Prevention of Occupational Heat-Related Illness among Outdoor Workers in the Power Grid Industry: A Cluster Randomized Controlled Trial.

Background: Occupational heat-related illness (OHI) is a health threat to workers that can be fatal in severe cases. Effective and feasible measures are urgently needed to prevent OHI.

Objectives: We evaluated the effectiveness of a multifaceted intervention, TEMP, in reducing the OHI risk among outdoor workers in the power grid industry.

Circular Dichroism and Interlayer Exciton Hall Effect in Transition Metal Dichalcogenides Homobilayers.

In van der Waals (vdW) architectures of transition metal dichalcogenides (TMDCs), the coupling between interlayer exciton and quantum degrees of freedom opens unprecedented opportunities for excitonic physics. Taking the MoSe homobilayer as representative, we identify that the interlayer registry defines the nature and dynamics of the lowest-energy interlayer exciton. The large layer polarization () is proved, which ensures the formation of layer-resolved interlayer excitons.

In situ structural-functional synchronous dissection of dynamic neuromuscular system via an integrated multimodal wearable patch.

Neuromuscular abnormality is the leading cause of disability in adults. Understanding the complex interplay between muscle structure and function is crucial for effective treatment and rehabilitation. However, the substantial deformation of muscles during movement (up to 40%) poses challenges for accurate assessment.

Role of the stratosphere in the global mercury cycle.

Mercury (Hg) is a global pollutant with substantial risks to human and ecosystem health. By upward transport in tropical regions, mercury enters into the stratosphere, but the contribution of the stratosphere to global mercury dispersion and deposition remains unknown. We find that between 5 and 50% (passing through the 400-kelvin isentropic surface and tropopause, respectively) of the mercury mass deposited on Earth's surface is chemically processed in the lower stratosphere.

Pore-Scale Study of Fluid Displacement in Parallel-Layered Porous Media and Implications of Associated Distinct Flow Dynamics.

Fluid displacement within layered porous media is more complex than in nonlayered ones. Most of the previous studies placed a focus on the porous media with layerings perpendicular to the flow direction, and the effects of pore topology were often ignored. Therefore, this study aims to reveal the flow physics in porous media with layering parallel to the flow direction by accounting for the specific pore topology.

Targeted Degradation of HCV Polymerase by GalNAc-Conjugated ApTACs for Pan-Genotypic Antiviral Therapy with High Resistance Barriers.

Hepatitis C virus (HCV) infection is a major cause of chronic liver disease. Although interferon-free direct-acting antivirals have led to significant advancements in the treatment of HCV infection, the high genetic variability of the virus and the emergence of acquired drug resistance pose potential threats to their effectiveness. In this study, we develop a broad-spectrum aptamer-based proteolysis targeting chimera, designated dNS5B, which effectively degrades both pan-genotypic NS5B polymerase and drug-resistant mutants through ubiquitin proteasome system.

Understanding the Role of Potential and Cation Effect on Electrocatalytic CO Reduction in All-Alkynyl-Protected Ag Nanoclusters.

Atomically precise metal nanoclusters (NCs) have emerged as an intriguing class of model catalysts for electrochemical CO reduction reactions (CORR). However, the interplay between the interface environment (e.g.

Direct Photocatalytic Oxidation of Methane to Formic Acid with High Selectivity via a Concerted Proton-Electron Transfer Process.

Light-driven direct conversion of methane to formic acid is a promising approach to convert methane to value-added chemicals and promote sustainability. However, this process remains challenging due to the complex requirements for multiple protons and electrons. Herein, we report the design of WO-based photocatalysts modified with Pt active sites to address this challenge.

Multipopulation Whale Optimization-Based Feature Selection Algorithm and Its Application in Human Fall Detection Using Inertial Measurement Unit Sensors.

Feature selection (FS) is a key process in many pattern-recognition tasks, which reduces dimensionality by eliminating redundant or irrelevant features. However, for complex high-dimensional issues, traditional FS methods cannot find the ideal feature combination. To overcome this disadvantage, this paper presents a multispiral whale optimization algorithm (MSWOA) for feature selection.

Dynamic Boronic Ester Cross-Linked Polymers with Tunable Properties via Side-Group Engineering.

The development of dynamic covalent materials with repairability, reprocessability, and recyclability is crucial for sustainable development. In this work, we report a new strategy to adjust the thermomechanical properties of boronic ester cross-linked poly(β-hydroxyl amine)s through side-group engineering. By tuning the side groups of the poly(β-hydroxyl amine)s, we have developed self-healable, reprocessable, and shape-programmable materials.

Influence and Mechanism of Solid-Phase Particle Factors on Oil-Solid Separation of Oily Sludge Treated by Flotation Method.

The solid phase composition in oily sludge (OS) is a key factor affecting the oil-solid separation of OS. In this paper, the effects and mechanisms of solid-phase particle factors on the oil content of residue phase were investigated in order to improve the oil-solid separation efficiency. Flotation experiments were carried out on single-size sand and mixed-size sand OS consisting of three particle sizes at room temperature without adding flotation reagents.

Genetic Characterization, Transmission Pattern and Health Risk Analysis of Intestinal Colonization ESBL-Producing in Vegetable Farming Population.

The surging prevalence rates of ESBL-producing (ESBL-Ec) pose a serious threat to public health. To date, most research on drug-resistant bacteria and genes has focused on livestock and poultry breeding areas, hospital clinical areas, natural water environments, and wastewater treatment plants. However, few studies have been conducted on drug-resistant bacteria in vegetable cultivation.

Effects of Distiller's Grains Biochar and on the Remediation of Cd-Pb-Zn-Contaminated Soil and Growth of Sorghum-Sudangrass.

Soil contamination with heavy metals is a significant environmental issue that adversely affects plant growth and agricultural productivity. Biochar and microbial inoculants have emerged as a promising approach to solving this problem, and previous studies have focused more on the remediation effects of single types of materials on heavy metal soil pollution. This study examined the impact of both standalone and combined applications of distiller's grains biochar, thallus, and the bacterial supernatant on the availability of cadmium (Cd), lead (Pb), and zinc (Zn) in soil, its physicochemical features, and its enzyme activities; this study also examined the growth, physiological and biochemical characteristics, and heavy metal accumulation of Sorghum-sudangrass.