5,034 results match your criteria: "Shahid Sadoughi University of Medical Sciences & Health Services[Affiliation]"

Article Synopsis
  • Diminished ovarian reserve (DOR) negatively impacts fertility by reducing the reproductive potential of the ovaries, partly due to changes in cumulus cell expression.
  • The study aimed to analyze circulating miRNA-4463 levels and its target gene cytochrome P450 19A1 in women with DOR, comparing them to women with normal ovarian reserve.
  • Findings indicated that higher levels of miR-4463 correlated with lower expression of the target gene in DOR women, suggesting that miR-4463 might provide insight into ovarian function and reserve predictions.
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  • Research compares flexible vs. fixed GnRH antagonist protocols in IVF for women with PCOS, as previous studies lacked sufficient evidence for such comparisons.
  • The study involved 150 PCOS infertile women, randomized into two groups to assess various IVF treatment outcomes.
  • Results showed the flexible protocol led to higher totals of oocytes and mature oocytes, suggesting better IVF outcomes compared to the fixed protocol.
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Therapeutic potentials of cannabidiol: Focus on the Nrf2 signaling pathway.

Biomed Pharmacother

October 2023

Department of Anesthesiology and Critical Care, School of Medicine, Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address:

Article Synopsis
  • Cannabidiol (CBD) is a non-psychoactive cannabinoid with various therapeutic benefits, drawing interest in its medical applications.
  • This study focuses on the relationship between CBD and the Nrf2 signaling pathway, which is linked to various health issues like cardiovascular problems and neurodegenerative diseases.
  • Research into how CBD interacts with Nrf2 could lead to new treatments for a variety of conditions, but further studies are needed to fully understand this connection.
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The association between Planetary Health Diet Index and the risk of colorectal cancer: a case-control study.

Sci Rep

November 2024

Department of Community Nutrition, Faculty of Nutrition and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background Despite the beneficial effects of a plant-based diet on colorectal cancer (CRC), no study has yet investigated the relationship between a Planetary Health Diet Index (PHDI) and CRC in the Iranian population. Therefore, the present case-control study aimed to assess the relationship between this index and CRC. Methods The current research was conducted on 71 patients with CRC (case group) and 142 (control group) admitted to hospitals in Tehran, Iran.

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  • - Polyamidoamine dendrimers (PAMAM) are synthetic polymers used for targeted drug delivery due to their defined structure and customizable features.
  • - The study focused on attaching methotrexate (MTX) to PAMAM loaded with berberine (BER) to target HeLa cancer cells, confirming the preparation through spectroscopy and particle size analysis.
  • - Biological tests showed that the MTX-PAMAM-BER combination significantly inhibited tumor cell growth compared to other treatments, highlighting its potential as an effective cancer therapy solution.
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  • Primary immunodeficiency diseases with partial albinism, such as Chediak Higashi Syndrome (CHS) and Griscelli Syndrome type 2 (GS2), are autosomal recessive disorders characterized by immune deficiencies and abnormal pigmentation.
  • The study evaluated 25 patients over the past decade, using genetic analyses and examinations of leukocyte granules and hair shafts to identify these conditions, along with control groups of patients with albinism and healthy individuals.
  • The findings indicated specific genetic variants associated with CHS and HPS2, highlighting the importance of timely hematopoietic stem cell transplantation and genetic testing for accurate diagnosis and management of these syndromes.
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Background: One of the growing diseases in today's human societies is cancer, which has become a major challenge, especially in industrialized and developing countries. Cancer treatments are diverse, but they usually use surgery, chemotherapy, and radiotherapy to improve patients. Existing drugs are usually expensive and, in some cases, are not effective due to drug resistance and side effects.

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Objective: The present study aimed to analyze the factors that influence the increase in the desire to re-engage volunteer rescuers and saviors of the Red Crescent Society of the Islamic Republic of Iran.

Methods: This qualitative descriptive phenomenological study involved the participation of volunteers who had not volunteered in the Iranian Red Crescent Society (IRCS) for at least one year but expressed a willingness to be re-engaged. The semi-structured in-depth interview process and data collection continued until the theoretical saturation stage was reached.

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The objective was to develop an active chitosan-based coating and to evaluate its effect on the shelf life and microbial safety of bread. Bacterial cellulose nanofibers (BCNF) and various levels (0.5%, 1%, and 2%) of silver nanoparticles (AgNPs) were in the chitosan (CS) film.

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Synthetic food antioxidants such as tert-butylhydroquinone (TBHQ), butylated hydroxyanisole (BHA), and propyl gallate (PG) have been extensively utilized in different food industries because of their high protectant activities to stop food spoilage and remove foodborne diseases in humans and animals. It would be emphasized that increasing the intake of antioxidants through intracellular may lead to cyto/genotoxicity, and their complex formation with biological molecules eventually accelerate the progress of various diseases like multiple sclerosis, diabetes, neurological disorders, cardiac vascular disease, cancer, etc. Therefore, their toxicity is one of the challenging subjects due to their extensive use in food-related industries.

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A growing body of evidence indicates the association of dietary advanced glycation end-products (dAGEs) with the risk of cancer. This systematic review and meta-analysis aimed to assess the overall association between dAGEs and cancer incidence. An extensive search was carried out through online databases including PubMed, Scopus, and Web of Science up to June 2024.

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Evaluation of Frequency of Celiac Disease in Children with Idiopathic Epilepsy.

Iran J Child Neurol

September 2024

Pediatric Gastroentrologist, Assistant Professor, Department of Pediatrics, Children Growth Disorder Research Center, School of Medicine, Shahid Sadoughi General Hospital, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

Objectives: Extra gastrointestinal symptoms in celiac disease (CD), such as neurological manifestations, might be common in pediatrics. The present study aimed to evaluate the frequency of CD in children with idiopathic epilepsy.

Materials & Methods: In a cross-sectional study, signs and symptoms of CD were evaluated in 40 children aged 2-14 years with idiopathic epilepsy who were referred to the Pediatric Neurology Clinic of Shahid Sadoughi Medical Sciences University, Yazd, Iran.

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Article Synopsis
  • Blood culture-negative endocarditis (BCNE) poses diagnosis challenges due to delays impacting patient outcomes.
  • A study in Tehran examined 50 BCNE patients, testing their sera for antibodies and heart valves for specific Bartonella DNA using real-time PCR.
  • Results revealed one patient with B. quintana detected, highlighting the potential role of Bartonella in BCNE and suggesting further research on animal reservoirs and at-risk groups.
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Background: Limited investigations have focused on the association between the Mediterranean dietary (MeD) and asthma among children and adolescents. We aimed to study the associations between a modified Mediterranean dietary pattern and asthma symptoms in children living in Iran.

Method: This cross-sectional study was conducted among 7667 children and adolescence.

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Unlabelled: Clinical translation of autophagy modulators is tied to thoroughly acquainted with the precise state of this process and its regulators in a particular cancer. LC3Av1 is a marker of autophagosome membrane that has been contributed with pathobiology of myriad of human cancers. In the present study, we examined the effect of promoter methylation and miR-155 and LncRNA-GAS5 (GAS5) expression levels on transcription of LC3Av1 in AML patients.

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Background: An earthquake has significant effects on health and livelihood of people. It is important to identify health needs and challenges of earthquake victims and use them to prepare for other possible earthquakes. Therefore, the purpose of this study is to explain the challenges and health needs of earthquake victims in Iran.

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Diagnostic and prognostic role of NLR in testicular cancer.

Explor Target Antitumor Ther

September 2024

Department of Neurosurgery, University of Florida, Gainesville, FL 32608, USA.

Article Synopsis
  • - The study investigated the neutrophil to lymphocyte ratio (NLR) and its implications in testicular cancer, finding that NLR is higher in patients than in healthy individuals or those with benign conditions.
  • - Post-surgery, specifically after orchiectomy, NLR levels significantly decrease, indicating a potential response to treatment.
  • - An elevated NLR is associated with several negative prognostic factors, such as advanced cancer stage and poorer outcomes, although it cannot distinguish between different types of testicular cancer.
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Article Synopsis
  • The study analyzed global, regional, and national trends in injury burden and identified risk factors contributing to injuries using data from the GBD 2019.
  • In 2019, there were approximately 713.9 million injury incidents and 4.3 million injury-related deaths globally, with low bone mineral density emerging as the leading risk factor.
  • The findings emphasize the need for effective global injury prevention policies by highlighting the persistent impact of injuries on global health.
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This case represents the first diagnosis of pachymeningitis due to granulomatosis with polyangiitis (GPA) in an elderly Iranian man who initially presented with persistent daily headaches. PCR tests of cerebrospinal fluid for tuberculosis, brucellosis, and fungal infections all yielded negative results. Given the pachymeningitis pattern observed on brain MRI and the absence of infectious and lymphoma diseases, along with positive anti-PR3 and proteinuria (793 mg in a 24-h urine sample), a diagnosis of GPA was established.

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Prevalence, Incidence, and Risk Factors of Hypothyroidism in Adult Residents of Yazd Greater Area, 2015-2021: Results of Yazd Health Study.

Iran J Med Sci

October 2024

Center for Healthcare Data Modeling, Department of Biostatistics and Epidemiology, School of Public Health, Shahid Sadougi Medical Sciences, Yazd, Iran.

Background: Any abnormal change in thyroid hormone levels leads to thyroid disorders, including hyperthyroidism, hypothyroidism, goiter, and so on. Recent studies have reported an increasing prevalence and incidence of thyroid disorders worldwide. This study aims to determine the hypothyroid prevalence, incidence, and risk factors related to this disorder.

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Individual observational studies examining the association between polyphenols and the risk of lung cancer have reported mixed findings. Therefore, we performed a systematic review and meta-analysis to determine the pooled effects between polyphenol intake and lung cancer risk. A systematic search was performed on PubMed, Scopus, and Web of Science databases in April 2023.

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Article Synopsis
  • Acute lymphoblastic leukemia is the most common type of cancer in children, and previous studies have linked CDKN2A gene variants to this illness, but further validation is needed.
  • This study analyzed data from multiple research databases, evaluating the relationship between specific CDKN2A polymorphisms (rs3731217 and rs3731249) and the risk of developing acute lymphoblastic leukemia in children.
  • Findings indicate that the rs3731217 variant may protect against leukemia, particularly in Caucasian and African children, while the rs3731249 variant appears to increase susceptibility, especially among pediatric patients.
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Today, there is a significant concern in the industry regarding the disposal of wastewater containing dyes into the environment, so the management and appropriate disposal of these wastes in the environment are considerable. The main aim of this study is to assess the efficiency of activated carbon (AC) prepared from sesame shells to remove direct dyes from aqueous solutions. According to the results, AC prepared from sesame shell had a high specific surface area (525 m/g) and porous structure.

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  • The study investigates the link between multi-directional cervical kyphoscoliosis (CKS) and crack cocaine addiction, as well as evaluating treatment results.
  • It presents three cases of patients with a history of crack cocaine abuse who developed CKS due to prolonged poor posture, treated with a complicated surgical method.
  • The results show successful surgeries restored spinal alignment with no significant complications, suggesting that long-term cocaine abuse may have a connection to CKS, and that complex surgical interventions can lead to positive outcomes.
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  • * The study analyzed data from nine randomized clinical trials, finding that AGE tea supplementation leads to a significant reduction in systolic and diastolic blood pressure among participants, particularly at doses over 1200 mg/day.
  • * While the findings suggest that AGE could be beneficial for lowering blood pressure, further well-structured trials are necessary to validate these results.
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