Comparison between intratympanic injection of dexamethasone and methylprednisolone in idiopathic sudden sensorineural hearing loss: A randomized clinical trial.

Objective: To compare the hearing outcomes of patients with idiopathic sudden sensorineural hearing loss after intratympanic (IT) injection of methylprednisolone and dexamethasone.

Study Design: Randomized case-controlled clinical trial.

Methods: Seventy-five patients diagnosed with idiopathic sensorineural hearing loss were randomly divided into two groups based on therapy.

Evaluation of a New Patellar Tendon Bearing Brace With Offloading Monitoring and Adjustability: A Pilot Study.

Background And Aims: The patellar tendon-bearing (PTB) brace is a crucial device designed to lessen axial forces on the tibia. The newly designed PTB brace allows clinicians to measure offloading amount in the realtime. This study aimed to explore the relationship between a rise in displacement between the foot plate and calf shells of this new PTB brace and changes in the amount of offloading on the tibia.

Functional Class II Treatment Simultaneous With Selective Reduction of Talon Cusps: A Case Report.

Selective reduction of bilateral nonsyndromic talon cusps in an 11-year-old class II patient enabled successful mandibular repositioning with a twin block appliance. This approach achieved desired orthodontic outcomes without causing pain or sensitivity following reduction, highlighting a novel strategy for managing talon cusps in orthodontic treatment.

A novel minimally invasive nonanatomical single-bundle medial collateral ligament reconstruction technique with a short isometric construct Achilles tendon allograft: A surgical description with clinical and radiological outcomes in multiligament knee injury patients.

Purpose: Multiligament knee injuries (MLKIs) involve various ligaments in the knee. Current double-bundle anatomical reconstructions of the medial collateral ligament (MCL) increase the level of technical complexity, often resulting in the establishment of numerous bone tunnels and different fixation points with additional hardware. To overcome these limitations, we proposed a novel minimally invasive nonanatomical MCL reconstruction with one tibial tunnel in the metaphysis using Achilles allograft in the MLKI setting.

Platelet-Leukocyte Aggregate and Interleukin-6: An Emerging Perspective on a New Diagnostic and Therapeutic Clue for Acute Coronary Syndrome, A Case-Control Study.

Background And Aims: Acute coronary syndrome (ACS) is one of the most important cardiovascular diseases. The rupture of atherosclerotic plaques in coronary arteries is considered the underlying pathophysiology of ACS. The interaction between cytokines and leukocytes in the presence of platelets results in platelet-leukocyte aggregate (PLA).

Effects of Resveratrol on Nonmelanoma Skin Cancer (NMSC): A Comprehensive Review.

Nonmelanoma skin cancer (NMSC) represents the most prevalent form of skin cancer globally, with basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) being the most common types. The search for effective chemopreventive and therapeutic agents has led to the exploration of natural compounds, among which resveratrol (RES), a polyphenolic phytoalexin found in grapes, berries, peanuts, and red wine, has garnered significant attention. This comprehensive review aims to elucidate the effects of RES on NMSC, focusing on its mechanisms of action, efficacy in preclinical studies, and potential as a chemopreventive and therapeutic agent.

The Impact of Vitamin E Supplementation on Oxidative Stress, Cognitive Functions, and Aging-Related Gene Expression in Aged Mice.

This study investigated the effects of different doses of vitamin E on oxidative stress, cognitive function, and gene expression in aged mice. A total of 32 male mice, aged 12 months, were divided into a control group and three treatment groups. These groups received varying daily doses of vitamin E for a period of 28 days.

Health risk assessment of heavy metals in black tea infusion by Monte Carlo simulation.

Tea leaves and their infusion have been interested in the populations because of their therapeutic and relaxing effects. However, tea plant is prone to heavy metals' bioaccumulation. Regarding the high consumption of tea infusion, concentration of arsenic, cadmium, and lead in black tea infusion was determined by inductively coupled plasma mass spectrometry.

Phytochemical composition, hypnotic activity, and antinociceptive properties of cumin essential oil collected from various geographical regions.

The quantity and quality of the active components of plants are strongly influenced by environmental factors. In this regard, dried cumin seeds were collected from four different locations (SaadatShahr (P1) and Sarvestan (P2) from Fars Province and Kashmar (P3) and Sabzevar (P4) from Khorasan), and their essential oils were isolated by Clevenger apparatus and evaluated using GC and GC-MS. In addition, the hypnotic and antinociceptive activities of the cumin EO sample, which had the highest yield and quality, respectively, were assessed via the pentobarbital-induced loss of righting test and acetic acid-induced writhing test.

Misdiagnosed for 14 Years: Adenosine Deaminase 2 (ADA2) Deficiency in a Teen Mimicking Polyarteritis Nodosa.

The deficiency of adenosine deaminase 2 (DADA2) is an autosomal recessive disorder caused by loss of function mutations in the ADA2 gene (previously the CECR1 gene) on chromosome 22q11. The clinical spectrum of the disease is remarkably broad, and its presentations mimic features of polyarteritis nodosa, such as livedoid rash, hematological abnormalities (e.g.

Administering antibiotic-loaded irrigation fluid as an alternative for prophylactic intravenous antibiotics in transurethral ureterolithotripsy (TUL): a randomized controlled trial.

Prophylactic antibiotics are commonly used to prevent infections and complications during surgeries. In this study inflammatory responses and infectious complications after utilizing antibiotic-loaded irrigation compared with intravenous (IV) prophylactic antibiotics. Eighty-eight participants with ureteral stones enrolled in this prospective randomized controlled trial.

Visit-to-visit variability of blood pressure and risk of diabetic retinopathy: a systematic review and meta-analysis.

Background: Diabetes mellitus (DM), a worldwide disease affecting more than 400 million people, is associated with high blood pressure (BP). In addition to macrovascular complications, high BP in DM patients is potentially linked to microvascular complications. More than 70% of DM patients have retinopathy.

Designing the Essential Informational Needs of a Smartphone Application for Self-Management of Patients With Inflammatory Bowel Disease.

Background And Aims: Inflammatory bowel disease (IBD) is a chronic digestive disease that has a detrimental effect on the quality of life of IBD patients. This study aims to identify the informational needs and design the essential informational needs for a smartphone application for the self-management of IBD.

Methods: This study was conducted in two stages and the informational needs of the patients were extracted in a questionnaire designed in three separate sections and given to 120 patients with UC and 60 patients with CD.

Procedures to evaluate potential of plants as natural food preservatives: Phytochemical characterization, novel extraction technology, and safety evaluation-A comprehensive review.

There is increasing demand for natural food preservative in food manufacturing industry as it is the key to meet consumers' preferences toward healthier food choice. Plant is listed among the most important resources of bioactive components to be utilized as the green and natural food preservatives. There are more than 10,000 kinds of bioactive components in plants that possess antioxidant and antimicrobial properties.

Effects of intrinsic and extrinsic growth factors on virulence gene expression of foodborne pathogens in vitro and in food model systems; a review.

Since foodborne diseases are one of the major causes of human hospitalization and death, one of the main challenges to food safety is the elimination or reduction of pathogens from food products throughout the food production chain. Pathogens, such as species, , , species, , , species, etc., enter the consumer's body through the consumption of contaminated food and eventually cause disease, disability, and death in humans.

Investigating the Prevalence of Hypercalciuria in Children Aged 2-16 Years With Asymptomatic Microscopic Hematuria in 2020 in Tehran Children's Medical Center.

The prevalence of hypercalciuria in children is 3%-10% globally and up to 35% in the United States. Hypercalciuria in children has many presentations; it causes different metabolic disorders and can negatively affect a child's growth. It also increases the risk of low bone mineral density and urinary tract infections.

A rare case of systemic lupus erythematosus presenting with concurrent myocarditis, central retinal vein occlusion, and deep vein thrombosis.

Although systemic lupus erythematosus may present with broad and variable symptoms, the rare and atypical combined presentation of central retinal vein occlusion, myocarditis, and deep vein thrombosis poses a diagnostic challenge and highlights the need for a comprehensive diagnostic approach. Early diagnosis and prompt treatment help mitigate disease morbidity and mortality, and emphasize the importance of heightened clinical suspicion in complex presentations.

Hurdle technology using enzymes and essential oil to remove biofilm and increase the effectiveness of this process with the microencapsulation method.

The formation of biofilm in different places and the failure to effectively remove it by the usual disinfection methods is due to its structure and the rich genetic resource available in it to deal with disinfectants. These impenetrable structures and diverse microbial genetics have caused biofilm pollution in different industries like the food industry, the medicine industry, the hospitals and the water distribution system, resulting in pathogenicity and reduction of industrial quality. An efficient way to deal with the resistant population of biofilm-forming microbes is the use of hurdle technology including enzymes and essential oils.

Kinetic changes of gait initiation in individuals with chronic ankle instability: A systematic review.

Background And Aims: Gait initiation (GI) in individuals with chronic ankle instability (CAI) has shown differences in the center of pressure (COP) and muscular measures compared to healthy controls. Some studies reported that these alterations appeared when GI was with the affected leg, while others indicated that they occurred when GI was with the non-affected leg. This systematic review aimed to understand kinetic and muscular differences between individuals with CAI, healthy controls, and the affected and non-affected legs of individuals with CAI.

Metabolic obesity phenotypes and thyroid cancer risk: A systematic exploration of the evidence.

Background: Obesity is recognized as a risk factor for various cancers, including thyroid cancer. However, the association between different metabolic obesity phenotypes and thyroid cancer risk remains unclear. This systematic review aimed to comprehensively evaluate the existing literature to elucidate the association between metabolic obesity phenotypes and thyroid cancer risk.