Methylation Status of miR-34a and miR-126 in Non-Small Cell Lung Cancer (NSCLC) Tumor Tissues.

Background: MiR-34a and miR-126 mainly act as tumor suppressors and are often downregulated in various cancers, including non-small cell lung cancer (NSCLC). We aimed to determine the methylation status of miR-34a and miR-126 in NSCLC patients.

Methods: The current study included 63 paraffin-embedded NSCLC and paired adjacent normal tissues.

Role of amyloid beta (25-35) neurotoxicity in the ferroptosis and necroptosis as modalities of regulated cell death in Alzheimer's disease.

Neuronal cell death as a prominent pathological feature contributes to cognitive decline and memory loss in Alzheimer's disease. We investigated the role of two forms of cell death pathways, ferroptosis and necroptosis, and their interactions following entorhinal cortex (EC) amyloidopathy. The Aβ was bilaterally injected into the rat's EC, and Morris Water Maze was applied to determine spatial performance one week after Aβ injection.

The Social Consequences of Infertility among Iranian Women: A Qualitative Study.

Background: Infertility may prevent couples to achieve the desired social roles and lead to some social and psychological problems. This study aimed to explain the social consequences of infertility in Iranian women seeking treatment.

Materials And Methods: A qualitative content analysis was conducted based on 32 semi-structured interviews with 25 women affected by primary and secondary infertility with no surviving children.

Expression patterns of c-Fos early gene and phosphorylated ERK in the rat brain following 1-h immobilization stress: concomitant changes induced in association with stress-related sleep rebound.

An immobilization stress (IS) of 1 h applied at the beginning of the dark phase is followed by a sleep rebound. During the restraint, serotonin released by the dorsal raphe nucleus within the arcuate area stimulates the availability of corticotropin-like intermediate lobe peptide (CLIP or ACTH18-39). Three hours after the restraint, CLIP, through its hypnogenic properties, contributes to the sleep rebound that follows the IS.

A role for endocannabinoids in acute stress-induced suppression of the hypothalamic-pituitary-gonadal axis in male rats.

Objective: Stress is known to be an inhibitor of the reproductive hypothalamic-pituitary-gonadal (HPG) axis. However, the neural and molecular connections between stress and reproduction are not yet understood. It is well established that in both humans and rodents, kisspeptin (encoded by the kiss1 gene) is a strong stimulator of the HPG axis.

The response of mouse embryonic stem cells to low doses of γ-radiation: evidence for an adaptive response.

Low doses of ionizing radiation may induce an adaptive mechanism which protects embryonic stem cells against higher doses, a phenomenon which was reported previously for somatic cells. In this study, a possible adaptive response (AR) was evaluated by measuring cell survival (MTT assay) and chromosomal aberrations (micronucleus assay). Thymidine-synchronized mouse embryonic stem cells (mESCs) were exposed to 2.

Lefort 1 osteotomy in a beta-thalassemia major patient--a case report.

Maxillary setback of patients with protruded maxilla is a complex procedure. This complexity is aggravated when combined with thalassemia. The Aim of this case report was to treat a beta-thalassemia major girl with severe maxillary protrusion.

A novel approach in treatment of open bite: a case report.

This case illustrates the treatment of a 12-year-old boy with an open bite, a slight Class II jaw relationship, Class I molar relationship, and a steep lower occlusal plane. The patient needed a surgical procedure due to the severity of openbite; however the surgery option was rejected. Therefore, he was treated by a Hyrax, fixed tongue appliance, posterior bite plate, reverse chin cup and fixed orthodontics.

Protective effect of cannabinoid CB1 receptor activation against altered intrinsic repetitive firing properties induced by Aβ neurotoxicity.

The amyloid β (Aβ) protein is believed to be the key pathological mediator of Alzheimer's disease (AD) which is the first and most well known type of dementia. Despite a growing body of evidence indicating that Aβ neurotoxicity induces changes in synaptic function, little effort, if any, has been made to investigate the effect of in vivo Aβ treatment on intrinsic neuronal properties. The present study was designed to examine the effects that in vivo Aβ treatment have on the intrinsic repetitive firing properties of CA1 pyramidal neurons, using whole cell patch clamp recording.

Serum levels of mannose-binding lectin and the risk of infection in pediatric oncology patients with chemotherapy.

Morbidity and mortality due to infections remain serious problems in pediatric oncology patients receiving chemotherapy. Association of mannose-binding lectin (MBL) levels with an increased risk for infection in previous studies was contradictory. The aim of this study was to determine whether MBL deficiency is associated with the risk of infections in pediatric oncology patients.

A comparison of argon laser and radiofrequency in trichiasis treatment.

Purpose: The aim of this study was to find concrete clinical evidence for determination of the best method of treatment for trichiasis and the location that responds best to treatment with radiofrequency and argon laser.

Methods: This study was performed in 2007 and 2008 on 100 patients, involving a total of 1,181 lashes in contact with the globe. Patients were randomly assigned to 2 groups of treatment: the radiofrequency group (group 1; 2 watts, 2- to 3-mm depth, cut-coagulating mode) and the argon laser group (group 2; spot size 50 μm, 760 mW, 930-nm wavelengths, continuous).

The study of Prevalence of Antigen HBs Positive and High-risk Behaviors in Pregnant Women Referring to Urban Health Centers of Isfahan Province in 2009.

Background: Around 5% of the world populations are the carriers of the hepatitis B virus. Prevalence of carriers in many different areas of the world is various. Iran, including the rate of 2 to 3%, is among countries, which has the average prevalence.

A novel method of maxillary deficiency treatment by tongue plate--a case report.

This case illustrates the treatment of a 6-year-old girl with Class III malocclusion and maxillary deficiency. The patient was treated by a tongue plate in the upper jaw. The tongue plate had two Adams clasps on the first maxillary molars, two C clasps on the deciduous maxillary canines and an acrylic plate posterior to the maxillary incisors.

A novel approach in treatment of maxillary deficiency by reverse chin cup.

The aim of this study was to evaluate the effectiveness of a newly designed small-sized extraoral appliance on Class III malocclusion and maxillary deficiency in growing patients. The case series included 10 patients (4 males, 6 females) with a mean age of 8.9 +/- 1.

In vivo 4-aminopyridine treatment alters the neurotoxin 3-acetylpyridine-induced plastic changes in intrinsic electrophysiological properties of rat cerebellar Purkinje neurones.

Electrophysiological dysfunction of Purkinje cells causes cerebellar ataxia. Recent studies indicated that 4-aminopyridine (4-AP) can prevent the attacks in patients with episodic ataxia type 2. However, the cellular mechanism(s) by which 4-AP might be beneficial for the improvement of motor function remain unclear.

Comparison of Mersilene mesh and autogenous fascia lata in correction of congenital blepharoptosis: a randomized clinical trial.

Purpose: To asses the functional results and complications of Mersilene mesh as an alternative to autogenous fascia lata in the management of low function ptosis.

Methods: In a randomized clinical trial, 31 eyelids with poor levator function were operated on. In 16 eyelids Mersilene mesh (Group A) and in 15 eyelids autogenous fascia lata were used for frontalis suspension procedure (Group B).

The effect of therapeutic touch on pain and fatigue of cancer patients undergoing chemotherapy.

Despite major advances in pain management, cancer pain is managed poorly in 80% of the patients with cancer. Due to deleterious side effects of pharmacology therapy in these people, there is an urgent need for clinical trials of non-pharmacological interventions. To examine the effect of therapeutic touch (TT) on the pain and fatigue of the cancer patients undergoing chemotherapy, a randomized and three-groups experimental study-experimental (TT), placebo (placebo TT), and control (usual care)-was carried out.

Morphological alteration in oro-facial CGRP containing motoneurons due to congenital thyroid hypofunction.

Under congenital thyroid hypofunction, the oro-facial large and small calcitonin gene-related peptide (CGRP) immunoreactive motoneurons were classified into strong, moderate, weak and negative intensity in offspring weaned rats. While 50% of neurons in the trigeminal motor nucleus (Mo5) were of the large type, this value dropped to 30% in hypothyroid pups. Hypothyroid trigeminal accessory nucleus (Mo5-AC) contained 10% large motoneurons versus about 45% in normal pups.

A study of the relationship between ameloblastoma and human papilloma virus.

Purpose: The purpose of this study was to determine the relation of ameloblastoma with one of its probable etiologic factors, human papilloma virus (HPV).

Materials And Methods: This study was carried out in a retrospective, observational, and blind manner with information forms using an exact polymerize chain reaction. Fifty paraffinated blocks of ameloblastoma tumor were compared with 50 impacted third molar follicles.

The epidemiology of end-stage renal disease in Iran in an international perspective.

Introduction: The epidemiology of end-stage renal disease (ESRD) and renal replacement therapy (RRT) is under continuous evolution all over the world. We report here the epidemiological analysis of ESRD and RRT in Iran and discuss it against the background of the international situation.

Methods: This epidemiological report is based on data from centre questionnaires which were collected in Iran from 1997 onwards, with a response rate of 100%.

Expressed emotion and the course of schizophrenia in Iran.

Background: The influence of expressed emotion (EE) on the course of the schizophrenia has been studied in different countries. Cultural influence on the level of EE has shown the importance of examination of EE in different cultures. The present study examined the distribution of components of EE and influence of EE on the course of schizophrenia in Iran.